Ricin: An Ancient Story for a Timeless Plant Toxin
Toxins, 2019 The castor plant (Ricinus communis L.) has been known since time immemorial in traditional medicine in the pharmacopeia of Mediterranean and eastern ancient cultures. Moreover, it is still used in folk medicine worldwide.
Letizia Polito +4 more
doaj +1 more source
Reduction of colonic inflammation in HLA-B27 transgenic rats by feeding Marie Ménard apples, rich in polyphenols [PDF]
, 2009 Inflammatory bowel diseases (IBD) are immunomediated ailments affecting millions of individuals. Although diet is regarded as an important factor influencing IBD, there are no accepted dietary recommendations presently available.
Baron, A. +18 more
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Saporin-S6: A Useful Tool in Cancer Therapy
Toxins, 2013 Thirty years ago, the type 1 ribosome-inactivating protein (RIP) saporin-S6 (also known as saporin) was isolated from Saponaria officinalis L. seeds. Since then, the properties and mechanisms of action of saporin-S6 have been well characterized, and it ...
Letizia Polito +4 more
doaj +1 more source
Nei-like 1 (NEIL1) excises 5-carboxylcytosine directly and stimulates TDG-mediated 5-formyl and 5-carboxylcytosine excision [PDF]
, 2017 Thymine DNA glycosylase (TDG) and Nei-like 1 (NEIL1) have both been implicated in the base excision repair step of active DNA demethylation. The robust glycosylase activity of TDG on DNA substrates containing 5-formylcytosine (5fC) or 5-carboxylcytosine (
Bochtler, Matthias +2 more
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Re-expression of IGF-II is important for beta cell regeneration in adult mice [PDF]
, 2012 Background The key factors which support re-expansion of beta cell numbers after injury are largely unknown. Insulin-like growth factor II (IGF-II) plays a critical role in supporting cell division and differentiation during ontogeny but its role in the
David Epstein +9 more
core +3 more sources
Oxidative DNA damage is instrumental in hyperreplication stress-induced inviability of Escherichia coli [PDF]
, 2014 En Escherichia coli, un aumento en la forma unida de ATP del iniciador de proteína DnaA da resultados en hiperiniciación e inviabilidad. Aquí, mostramos que dicha replicación de estrés es tolerada en el crecimiento anaeróbico.
Bjørn, Louise +4 more
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An effort to make sense of antisense transcription in bacteria [PDF]
, 2012 Analysis of bacterial transcriptomes have shown the existence of a genome-wide process of overlapping transcription due to the presence of antisense RNAs, as well as mRNAs that overlapped in their entire length or in some portion of the 5'- and 3'-UTR ...
Gingeras, T. R. +2 more
core +1 more source
APE1/Ref-1 Role in Redox Signaling: Translational Applications of Targeting the Redox Function of the DNA Repair/Redox Protein APE1/Ref-1 [PDF]
, 2012 The heterogeneity of most cancers diminishes the treatment effectiveness of many cancer-killing regimens. Thus, treatments that hold the most promise are ones that block multiple signaling pathways essential to cancer survival.
Fishel, Melissa L. +2 more
core +1 more source
International Journal of Biological MacromoleculesSeveral studies highlight the identification of some enzymes with additional abilities, especially those involved in metabolic pathways and/or host defence processes, classified as multitasking proteins. In this context, we report the characterization of melleatin (17.5-kDa), a multitasking enzyme isolated from Armillaria mellea fruiting bodies ...
Hussain, Hafiza Z F +11 more
openaire +3 more sources
Membrane-translocating peptides and toxins: from nature to bedside [PDF]
, 2008 Today, different functional classes of bioactive peptides and toxins isolated from diverse sources of living organisms are known. In medicine, these polypeptides present the potential to be used structurally unmodified or to serve as templates for ...
Hayashi, Mirian Akemi Furuie +5 more
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