Results 11 to 20 of about 18,590,986 (140)

Chloroplast- and mitochondrion-specific random C-to-T mutagenesis for forward genetics of organelle genomes. [PDF]

Plant J
Significance Statement This study provides a chloroplast‐ and mitochondrion‐specific random mutagenesis tool specialized for C‐to‐T substitutions, enabling organelle genome‐focused forward genetic analysis. By utilizing this tool, we can screen for organelle genome‐associated traits and isolate novel mutations that are not only of physiological ...
Kosaka N, Harada Y, Nakazato I, Okuno M, Itoh T, Tsutsumi N, Arimura SI.   +6 more
europepmc   +2 more sources

Cytochrome P450 1a (CYP1A)-Knockout Javanese Medaka Fish Exhibit Diabetic Traits and Reduced Reproductive Capacity. [PDF]

FASEB J
Analyses of cytochrome P450 1a (CYP1A)‐knockout (KO) Javanese medaka (Oryzias javanicus) revealed that CYP1A is involved in glucose regulation and reproduction. In the KO fish, significant increases in hepatic transcripts of insulin, glucagon, and somatostatin genes, as well as elevated blood glucose, liver mass, and liver triglyceride levels ...
Rusni S, Yoshioka Y, Pratiwi HM, Takagi T, Royan MR, Hojo Y, Uno S, Kanda S, Takehana Y, Kinoshita M, Inoue K.   +10 more
europepmc   +2 more sources

Intratumoral Microorganisms in Tumors: Current Understanding and Emerging Therapeutic Strategies. [PDF]

MedComm (2020)
Tumors are no longer viewed as sterile but dynamic ecosystems harboring low‐biomass intratumoral microbiota. These microbes, derived from gut, oral cavity, or circulation, shape tumorigenesis and therapy response via core mechanisms: immunomodulation (regulating T cells, macrophages), metabolic reprogramming (SCFAs, indoles, bile acids), chronic ...
Zhang H, Du Z, Lu P, Jiang A, Guo Y, Liu Y, Song Z, Dai B, Zhang W.   +8 more
europepmc   +2 more sources

Oxidative stress and 8-oxoguanine repair are enhanced in colon adenoma and carcinoma patients. [PDF]

, 2010
Oxidative stress is involved in the pathogenesis of colon cancer. We wanted to elucidate at which stage of the disease this phenomenon occurs. In the examined groups of patients with colorectal cancer (CRC, n = 89), benign adenoma (AD, n = 77) and ...
R. Rozalski, A. Szpila, B. Tudek, Speina, Elzbieta, Oliński, Ryszard, Janowska, Beata, J. Janik, Obtułowicz, Tomasz, Janik, Justyna, T. Dziaman, Dziaman, Tomasz, Szpila, Anna, J. M. Ciesla, Siomek, Agnieszka, A. Siomek, Cieśla, Jarosław M., Jawien, Arkadiusz, Gackowski, Daniel, M. Swoboda, E. Speina, R. Olinski, Swoboda, Maja, D. Gackowski, Guz, Jolanta, B. Janowska, J. Guz, Z. Banaszkiewicz, A. Jawien, Rozalski, Rafał, T. Obtulowicz, Tudek, Barbara, Banaszkiewicz, Zbigniew   +31 more
core   +2 more sources

A mutant of uracil DNA glycosylase that distinguishes between cytosine and 5-methylcytosine [PDF]

, 2014
We demonstrate that a mutant of uracil DNA glycosylase (N123D:L191A) distinguishes between cytosine and methylcytosine. Uracil DNA glycosylase (UDG) efficiently removes uracil from DNA in a reaction in which the base is flipped into the enzyme’s active ...
Fox, Keith R., Kimber, Scott T., Keith R. Fox, Brown, T, Fox, KR, Tom Brown, Brown, Tom, Brown, Thomas, Kimber, ST, Scott T. Kimber, Scott T Kimber, Keith R Fox   +11 more
core   +2 more sources

Architecturally diverse proteins converge on an analogous mechanism to inactivate Uracil-DNA glycosylase [PDF]

, 2013
Uracil-DNA glycosylase (UDG) compromises the replication strategies of diverse viruses from unrelated lineages. Virally encoded proteins therefore exist to limit, inhibit or target UDG activity for proteolysis.
Cole, Ambrose R., Savva, Renos, Baltulionis, Gediminas, Ofer, S, Hornyak, P, Ryzhenkova, K, Baltulionis, G, Cole, AR, Ofer, Sapir, Savva, R, Ryzhenkova, Ksenia, Hornyak, Peter   +11 more
core   +1 more source

A function of thymine DNA glycosylase-initiated DNA repair in maintaining epigenome stability [PDF]

, 2013
The Thymine DNA Glycosylase (TDG) was initially discovered by its ability to excise the deamination products of cytosine and 5-methylcytosine (5-mC), and therefore thought to initiate base excision repair (BER) of the resulting G•U and G•T mismatches.
Jacobs, Angelika L.
core   +1 more source

SLURP2 Enlarges Adipocytes and Induces IL-23-Producing Macrophages in Murine Dermal Adipose Tissue. [PDF]

Exp Dermatol
ABSTRACT Dermal adipocytes have unique features different from visceral and subcutaneous adipocytes. Their cyclic remodelling is coupled with hair follicle (HF) cycling: expansion in the anagen and reduction in the catagen stages. Secreted Ly6/uPAR related protein 2 (SLURP2) is a non‐neuronal transmitter and a ligand of both nicotinic and muscarinic ...
Tsuji H, Mabuchi T.
europepmc   +2 more sources

A model for 3-methyladenine recognition by 3-methyladenine DNA glycosylase I (TAG) from Staphylococcus aureus [PDF]

, 2012
The removal of chemically damaged DNA bases such as 3-methyladenine (3-MeA) is an essential process in all living organisms and is catalyzed by the enzyme 3-MeA DNA glycosylase I.
Zhu, Xiaofeng, Coote, Peter J., Liu, Huanting, Naismith, James, Carter, Lester G., Graham, Shirley, Yan, Xuan   +6 more
core   +1 more source

Identification of a novel methyltransferase, Bmt2, responsible for the N-1-methyl-adenosine base modification of 25S rRNA in "Saccharomyces cerevisiae" [PDF]

, 2013
The 25S rRNA of yeast contains several base modifications in the functionally important regions. The enzymes responsible for most of these base modifications remained unknown.
Sharma, Sunny, Watzinger, Peter, Entian, Karl-Dieter, Kötter, Peter   +3 more
core   +1 more source