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Clock Genes Regulate Ca2+ Signaling and Mitochondrial Bioenergetics to Inhibit Sjögren Disease
Objective Although Ca2+ signaling and metabolism have been identified as key determinants for the development of Sjögren disease (SjD), the intricate connection between them and salivary gland physiology remains poorly understood. Methods Fluorescence‐based Ca2+ imaging, RNA sequencing, and mitochondrial activity were used to investigate the effects of
Viktor R. Drel +12 more
wiley +1 more source
Complement Activation Linked to Type II Interferon Signaling in Still Disease
Objective Still disease (SD) is an autoinflammatory syndrome characterized by innate immune dysregulation. Although complement can drive inflammation, its involvement in SD remains to be defined. Thus, we aimed to assess complement activation in SD. Methods Complement was assessed using transcriptomic, proteomic, and in vitro approaches. RNA sequencing
Freya M. C. H. Huijsmans +115 more
wiley +1 more source
ABSTRACT Neisseria gonorrhoeae poses an urgent public health challenge due to rapidly increasing antimicrobial resistance and the absence of an effective vaccine. Targeting conserved bacterial pathways involved in essential physiological processes may provide new opportunities for vaccine antigen discovery.
Sinethemba H. Yakobi +1 more
wiley +1 more source
Cost-efficient filtration and replication strategies match or exceed detection sensitivity for marine eDNA diversity at an intertidal site under a standardized laboratory workflow. [PDF]
Schulte NO +6 more
europepmc +1 more source
Decoding a polyamine signal to direct vascular fate: thermospermine meets the ribosome. [PDF]
Silva LAS, Dogramaci M, Otoni WC.
europepmc +1 more source
Genes near tRNAs are enriched in translational machinery. [PDF]
West C, Dineen L, LaBella AL.
europepmc +1 more source
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Molecular Biology Reports, 1996
RNase MRP is a ribonucleoprotein enzyme with a structure similar to RNase P. It is required for normal processing of precursor rRNA, cleaving it in the Internal Transcribed Spacer 1.
Lasse Lindahl, Janice M Zengel
exaly +3 more sources
RNase MRP is a ribonucleoprotein enzyme with a structure similar to RNase P. It is required for normal processing of precursor rRNA, cleaving it in the Internal Transcribed Spacer 1.
Lasse Lindahl, Janice M Zengel
exaly +3 more sources
Recovering rRNA processing after heat shock
NF-κB repressing factor controls localization and activation of an rRNA processing protein in heat stress response.
Alexandra A. Mushegian
openaire +3 more sources
Modelling Yeast Pre-rRNA Processing
2007In this paper we present a quantified model concerning the synthesis of pre-rRNAs. The chemical kinetics simulation software Dizzy has been chosen as both the modelling and simulation framework of our study. We discuss the validation of the model against the available experimental data and we show some preliminary results obtained from the study of our
Federica Ciocchetta +3 more
openaire +2 more sources

