Results 241 to 250 of about 1,917,084 (305)

Introducing Borsantrazole: A Trifunctional Boron‐Based Pyrazole That Extends the Lifespan of Amyotrophic Lateral Sclerosis Mice

Advanced Science, EarlyView.
Herein we report a boron‐based pyrazole, (Borsantrazole ‐ a small molecule that selectively targets oxidative stress) that significantly increases survival, reduces weight loss, delays disease onset, and affects global protein changes in the SOD1‐G37R mouse model of ALS.
Nitesh Sanghai, Rhonda Kelley, Ying Lao, M. Immanuel Reyes Madlangsakay, Prasanta Paul, M. Alejandra Llanes‐Cuesta, Jun‐Feng Wang, René P. Zahedi, Jiming Kong, Geoffrey K. Tranmer   +9 more
wiley   +1 more source

Enhanced rabies surveillance in roadkill specimens by real-time RT-PCR. [PDF]

PLoS Negl Trop Dis
Gigante CM, Hartloge C, Condori RE, Kirby JD, Hovis L, Nelson KM, Wallace R, Li Y, Chipman RB.   +8 more
europepmc   +1 more source

PFKFB4 Deubiquitination by USP10 Enhances Fumarate Metabolism to Orchestrate the KDM1A/Rad51 Axis and Confer Radioresistance in Lung Cancer

Advanced Science, EarlyView.
USP10 binds to and stabilizes PFKFB4, enhancing glycolytic ATP production, which activates the urea cycle and elevates fumarate. This inhibits histone demethylase KDM1A, leading to increased H3K4me1 enrichment at the Rad51 promoter and direct activation of Rad51 transcription, which confers lung cancer radioresistance. The PFKFB4 inhibitor 5MPN targets
Yunshang Chen, Zilong Wu, Yongqiang Yang, Ruoxin Fang, Huichan Xue, Rui Zhou, Gang Wu, Xiaohua Jie   +7 more
wiley   +1 more source

Design and performance of a real-time RT-PCR assay for detection of influenza C viruses. [PDF]

J Clin Virol
Shu B, Davis WG, Liu J, Thielen BK, Bistodeau S, Lynch B, Warnes CM, Liddell J, Strain AK, Christensen J, Wong P, Burnett N, Davis TC, Kirby MK.   +13 more
europepmc   +1 more source

Comparative Performance of Digital PCR and Real-Time RT-PCR in Respiratory Virus Diagnostics. [PDF]

Viruses
Bianconi I, Pellecchia GV, Incrocci EM, Vittadello F, Nicoletti M, Pagani E.   +5 more
europepmc   +1 more source

Modeling the effectiveness of RT-PCR, RT-LAMP, and antigen testing strategies for COVID-19 control. [PDF]

BMC Infect Dis
Chantanasaro T, Sararat C, Yolai N, Suttirat P, Nawattanapaiboon K, Chauvatcharin S, Chadsuthi S, Modchang C.   +7 more
europepmc   +1 more source

Validation of China's 2025 high-risk criteria in RT-PCR-confirmed chikungunya inpatients: a single-centre retrospective cohort. [PDF]

BMC Infect Dis
Yang S, Wan Z, Zhan L, Zhang H, Lin Y, Weng Z, Wang X, Su Z, Yu X.   +8 more
europepmc   +1 more source

Combining Suction-Pipette Spectral Identification With Single-Cell RT-PCR to Make Differential Analyses of Amphibian Red and Green Rods. [PDF]

Bio Protoc
Chernyshkova OV, Nikolaeva DA, Meshalkina DA, Veligura VI, Firsov ML.   +4 more
europepmc   +1 more source

Diagnostic concordance of GeneXpert HCV VL fingerstick and GeneXpert HCV viral load with RT-PCR in POCT settings among hemodialysis patients. [PDF]

PLoS One
Sulaiman AS, Nugroho P, Bahri DR, Rachmani D.   +3 more
europepmc   +1 more source

Importance of a heat snap in RT-PCR quantification of rotavirus double-stranded RNA in wastewater.

Environ Sci (Camb)
Kang S, Wettlauffer A, de Korne-Elenbaas J, Niwagaba CB, Strande L, Duong D, Shelden B, Julian TR, Boehm AB.   +8 more
europepmc   +1 more source