Results 131 to 140 of about 1,081,218 (337)
Improving the standardization of mRNA measurement by RT-qPCR [PDF]
Biomolecular Detection and Quantification, 2018 Human health and safety depend on reliable measurements in medical diagnosis and on tests that support the selection and evaluation of therapeutic intervention and newly discovered molecular biomarkers must pass a rigorous evaluation process if they are to be of benefit to patients.
Rebecca Sanders +3 more
openaire +3 more sources
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
Involvement of UDP-Glucuronosyltransferases and Sulfotransferases in the Excretion and Tissue Distribution of Resveratrol in Mice. [PDF]
, 2017 Resveratrol is a naturally occurring polyphenolic compound with various pharmacological activities. It is unknown whether the expression of metabolizing enzymes correlates with resveratrol levels in organs and tissues.
Brenner, Stefan +8 more
core +2 more sources
Frontiers in Physiology, 2018 Reverse transcriptase-quantitative polymerase chain reaction (RT-qPCR) is a reliable technique for quantifying expression levels of targeted genes during various biological processes in numerous areas of clinical and biological research.
Jing Lü +3 more
semanticscholar +1 more source
Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA
Molecular Oncology, EarlyView.Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson +2 more
wiley +1 more source
Guangxi Yike Daxue xuebaoObjective To evaluate the diagnostic value of reverse transcription-quantitative polymerase chain reaction (RT-qPCR) detection of skin pus specimens in HIV-negative patients with talaromycosis marneffei (TSM).
Lan HUANG +7 more
doaj +1 more source
Analysis of
Molecular Cytogenetics, 2012 Background ZAP70 gene expression is associated with poor prognosis in B-cell lymphoproliferative disorders especially chronic lymphocytic leukaemia (CLL) but its role in adult B-ALL has not been established.
Chakupurakal Geothy +4 more
doaj +1 more source
Benchmarking of RNA-sequencing analysis workflows using whole-transcriptome RT-qPCR expression data
Scientific Reports, 2017 RNA-sequencing has become the gold standard for whole-transcriptome gene expression quantification. Multiple algorithms have been developed to derive gene counts from sequencing reads.
C. Everaert +6 more
semanticscholar +1 more source
, 2017 Procedure used for RT-qPCR in the WetLab-2 ...
Jimmy Jung, Macarena Parra
openaire +1 more source
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source