Results 61 to 70 of about 917,459 (311)
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
, 2018 EF1a was used as the internal control. The error bars represent the SE of the RT-qPCR data (n = 3). “r” represents the Pearson correlation coefficient.
Chun-Mei Wang (2507503) +8 more
core +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Journal of Health Science and Medical Research (JHSMR)Objective: To determine the diagnostic sensitivity and specificity of reverse transcription-loop-mediated isothermal amplification (RT-LAMP) compared to those of reverse transcription-quantitative polymerase chain reaction (RT-qPCR) for coronavirus ...
Aekkaraj Nualla-ong +11 more
doaj +1 more source
BMC Pediatrics, 2010 Background Neonatal sepsis is difficult to diagnose and pathogens cannot be detected from blood cultures in many cases. Development of a rapid and accurate method for detecting pathogens is thus essential.
Sato Hiroaki +10 more
doaj +1 more source
Algorithm Optimization in Methylation Detection with Multiple RT-qPCR. [PDF]
PLoS ONE, 2016 Epigenetic markers based on differential methylation of DNA sequences are used in cancer screening and diagnostics. Detection of abnormal methylation at specific loci by real-time quantitative polymerase chain reaction (RT-qPCR) has been developed to ...
Lele Song +10 more
doaj +1 more source
High-throughput microfluidic single-cell RT-qPCR [PDF]
Proceedings of the National Academy of Sciences, 2011 A long-sought milestone in microfluidics research has been the development of integrated technology for scalable analysis of transcription in single cells. Here we present a fully integrated microfluidic device capable of performing high-precision RT-qPCR measurements of gene expression from hundreds of single cells per run.
Adam K, White +8 more
openaire +2 more sources
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source