Results 71 to 80 of about 917,459 (311)
, 2023 RT-qPCR average Cq for 20 DSLD horse skin samples and 18 control horse skin samples. The Cq values were average of total 20 DSLD horse skin samples and 18 normal horse skin samples. Each sample was run twice in triplicates.
Jennifer Hope Roberts (16548590) +6 more
core +1 more source
Influence of RT-qPCR primer position on EGFR interference efficacy in lung cancer cells
Biological Procedures Online, 2010 Background Real-time quantitative RT-PCR (RT-qPCR) is a "gold" standard for measuring steady state mRNA levels in RNA interference assays. The knockdown of the epidermal growth factor receptor (EGFR) gene with eight individual EGFR small interfering RNAs
Chen Gang +3 more
doaj +1 more source
Endogenous Heparin Interferes with Quantification of MicroRNAs by RT-qPCR [PDF]
Clinical Chemistry, 2018 To the Editor: MicroRNAs (miRNAs)1 are small noncoding RNAs that regulate the expression of target genes, thereby contributing to disease development. The discovery of their presence in the bloodstream has stimulated extensive characterization of their potential as disease biomarkers.
Adeline, Boileau +3 more
openaire +2 more sources
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
CEACAM1 participation in breast cancer progression
Molecular Oncology, EarlyView.In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin +3 more
wiley +1 more source
Heterogeneous expression of EPCAM in human circulating tumour cells from patient-derived xenografts
Biomarker Research, 2018 Background We aim to characterize the heterogeneous circulating tumour cells (CTCs) in peripheral blood, independently of physical or immunological purification, by using patient-derived xenografts (PDXs) models.
Chiara Agnoletto +9 more
doaj +1 more source
BMC Infectious Diseases, 2022 Background The COVID-19 pandemic remains the main public health problem, due to the quick and easy dissemination of the causal agent, SARS-CoV-2 virus, around the world.
Diana Flores-León +5 more
doaj +1 more source
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source