Results 81 to 90 of about 952,520 (310)
Endogenous Heparin Interferes with Quantification of MicroRNAs by RT-qPCR [PDF]
Clinical Chemistry, 2018 To the Editor: MicroRNAs (miRNAs)1 are small noncoding RNAs that regulate the expression of target genes, thereby contributing to disease development. The discovery of their presence in the bloodstream has stimulated extensive characterization of their potential as disease biomarkers.
Adeline, Boileau +3 more
openaire +2 more sources
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source
Heterogeneous expression of EPCAM in human circulating tumour cells from patient-derived xenografts
Biomarker Research, 2018 Background We aim to characterize the heterogeneous circulating tumour cells (CTCs) in peripheral blood, independently of physical or immunological purification, by using patient-derived xenografts (PDXs) models.
Chiara Agnoletto +9 more
doaj +1 more source
BMC Infectious Diseases, 2022 Background The COVID-19 pandemic remains the main public health problem, due to the quick and easy dissemination of the causal agent, SARS-CoV-2 virus, around the world.
Diana Flores-León +5 more
doaj +1 more source
RT-qPCR primer sequences used in the present study.
, 2023 RT-qPCR primer sequences used in the present study.
Joong-Woon Lee (15332874) +8 more
core +1 more source
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
, 2018 EF1a was used as the internal control. The error bars represent the SE of the RT-qPCR data (n = 3). “r” represents the Pearson correlation coefficient.
Chun-Mei Wang (2507503) +8 more
core +1 more source