Results 51 to 60 of about 103,717 (290)
Molecular Oncology, EarlyView.ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang +8 more
wiley +1 more source
Mokslo Taikomieji Tyrimai Lietuvos Kolegijose, 2021 Statybos planavimo ir valdymo veikloje taikomos technologijos, susijusios su įvairiomis erdvinių duomenų kombinacijomis, iš kurių gaunami reikšmingi rezultatai apie tiriamą objektą.
Vilma Kriaučiūnaitė-Neklejonovienė +1 more
doaj
Positive and negative tissue-specific signaling by a nematode epidermal growth factor receptor [PDF]
, 1997 The major determinants of receptor tissue tyrosine kinase (RTK) signaling specificity have been proposed to be Src homology 2 (SH2) binding sites, phosphotyrosine-containing oligopeptides in the cytoplasmic domain of the receptor.
Lesa, Giovanni M., Sternberg, Paul W.
core
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Induction of MET Receptor Tyrosine Kinase Down-Regulation through Antibody-Mediated Receptor Clustering [PDF]
, 2019 The proto-oncoprotein MET is a receptor tyrosine kinase that plays a key role in cancer cell growth and invasion. We have used fluorescence-tagged antibodies to activate MET in live serum-starved glioblastoma cells and monitor the fate of antibody-bound ...
Adam Dick +4 more
core +3 more sources
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
GNSS techniques for real-time monitoring of landslides: a review
Satellite Navigation, 2023 Currently, Global Navigation Satellite System (GNSS) Real-Time Kinematic positioning (RTK) and Precise Point Positioning (PPP) techniques are widely employed for real-time monitoring of landslides.
Guanwen Huang, Shi Du, Duo Wang
doaj +1 more source
Applied Sciences, 2022 Global Navigation Satellite System Real-time Kinematic (GNSS-RTK) is an indispensable source for the absolute positioning of autonomous systems. Unfortunately, the performance of the GNSS-RTK is significantly degraded in urban canyons, due to the ...
Jiachen Zhang +5 more
doaj +1 more source
Consistency Analysis of RTK and Non-RTK UAV DSMs in Vegetated Areas
IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing, 2023 Lately, unmanned aerial vehicles (UAVs) evolve into one of the most popular remote sensing technologies by providing rapid and periodical acquisition of high-resolution, accurate, and low-cost aerial data. Progressively, the technology of UAVs rises with the addition of advanced equipment such as multispectral (MS) digital cameras and global navigation
Umut Gunes Sefercik, Mertcan Nazar
openaire +2 more sources
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source