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Genomic Diversity and Runs of Homozygosity in Bernese Mountain Dogs
Genes, 2023 Bernese mountain dogs are a large dog breed formed in the early 1900s in Switzerland. While originally farm dogs that were used for pulling carts, guarding, and driving cattle, today they are considered multi-purpose companion and family dogs. The breed is predisposed to several complex diseases, such as histiocytic sarcoma, degenerative myelopathy, or Anna Letko, Benoît Hédan, Anna Snell, Alexander C. Harris, Vidhya Jagannathan, Göran Andersson, Bodil S. Holst, Elaine A. Ostrander, Pascale Quignon, Catherine André, Tosso Leeb +10 moreopenaire +4 more sourcesA method for genotyping elite breeding stocks of leaf chicory (Cichorium intybus L.) by assaying mapped microsatellite marker loci [PDF]
, 2015 BACKGROUND:
Leaf chicory (Cichorium intybus subsp. intybus var. foliosum L.) is a diploid plant species (2n = 18) of the Asteraceae family. The term "chicory" specifies at least two types of cultivated plants: a leafy vegetable, which is highly ...Barcaccia, Gianni, Cadalen, Thierry, Caenazzo, Silvano Tiozzo, Galla, Giulio, Ghedina, Andrea, Hilbert, Jean Louis +5 morecore +2 more sourcesDystrophic Epidermolysis Bullosa: COL7A1 Mutation Landscape in a Multi-Ethnic Cohort of 152 Extended Families with High Degree of Customary Consanguineous Marriages [PDF]
, 2017 Dystrophic epidermolysis bullosa is a heritable skin disease manifesting with sub-lamina densa blistering, erosions, and chronic ulcers. COL7A1, encoding type VII collagen, has been identified as the candidate gene for dystrophic epidermolysis bullosa. In Abiri, Maryam, Barzegar, Mohammadreza, Ertel, Adam, Fortina, Paolo, Kajbafzadeh, Abdol Mohammad, Mozafari, Nikoo, Saeidian, Amir Hossein, Sotoudeh, Soheila, Uitto, Jouni, Vahidnezhad, Hassan, Youssefian, Leila, Zeinali, Sirous +11 morecore +1 more sourceФормирование эмоциональной культуры как компонента инновационной культуры студентов [PDF]
, 2009 Homozygosity has long been associated with rare, often devastating, Mendelian disorders1 and Darwin was one of the first to recognise that inbreeding reduces evolutionary fitness2.A Abdellaoui, A Garrod, A Wright, Abdel Abdellaoui, Adesola Ogunniyi, Adolfo Correa, Alan F. Wright, Alan R. Shuldiner, Alanna Morrison, Albert V. Smith, Albertine J. Oldehinkel, Alena Stančáková, Alexander Drong, Alexander Teumer, Alice V. Stanton, Aliki-Eleni Farmaki, Amelie Bonnefond, Anders Hamsten, Andre G. Uitterlinden, Andres Metspalu, Andrew A. Hicks, Andrew Bjonnes, Andrew D. Morris, Andrew P. Morris, Andrew R. Wood, Angela Matchan, Anil K. Giri, Anke Tönjes, Anna Maria Töglhofer, Annamari Lundqvist, Anne U. Jackson, Anni Joensuu, Antonietta Robino, Antti-Pekka Sarin, Anu Loukola, AR Wood, Aravinda Chakravarti, Archie Campbell, Ashley van der Spek, Astrid van Hylckama Vlieg, Atsushi Takahashi, Babatunde Salako, Bamidele O. Tayo, Bengt Sennblad, Benjamin Lehne, Beverley Balkau, Bjarke Feenstra, Blair H. Smith, Bruce M. Psaty, C Darwin, C Darwin, CA Rietveld, Carole Ober, Caroline Hayward, Caroline S. Fox, Cecilia M. Lindgren, Charles Gu, Charles N. Rotimi, Chittaranjan S. Yajnik, Chris Haley, Christa Meisinger, Christian Gieger, Christopher J. Hammond, Cinzia Sala, CJ Willer, Claude Bouchard, Claudia Schurmann, Clemens Baumbach, Colin N. A. Palmer, Constance Chen, Cornelia M. van Duijn, Cornelius A. Rietveld, Corrado Masciullo, Cristian Pattaro, Cristina Menni, D Charlesworth, Daniel I. Chasman, Daniel J. Benjamin, Daniel Shriner, Daniela Ruggiero, Daniela Toniolo, Daniele Cusi, David A. Mackey, David C.M. Liewald, David J. Porteous, David P. Strachan, David R. Weir, Degui Zhi, Dhananjay Vaidya, Dharambir K. Sanghera, Diane M. Becker, Diego Vozzi, Donna K. Arnett, Dorret I. Boomsma, Dragana Vuckovic, Dwaipayan Bharadwaj, Edith Hofer, Eero Vuoksimaa, Efthymia Vlachopoulou, Eleftheria Zeggini, Eric Boerwinkle, Erik Ingelsson, Erika Salvi, Erin B. Ware, Erkki Vartiainen, Erwin P. Bottinger, Evelin Mihailov, F Galton, Folkert W. Asselbergs, Francesca Pavani, Francine Grodstein, Francis S. Collins, Frank D. Mentch, Frank Geller, Gail Davies, GB Ehret, Generation Scotland, Georg Ehret, Georg Homuth, George Davey Smith, George Dedoussis, George T. O'Connor, Gerard Pasterkamp, Gianluigi Zaza, Gibran Hemani, Giorgia Girotto, Giovanni Gambaro, Giovanni Malerba, Giriraj R. Chandak, Gonneke Willemsen, Grant W. Montgomery, H Campbell, H Lango Allen, H Najmabadi, H Stefansson, Hakon Hakonarson, Hannele Mattsson, Hans Bisgaard, Hao Mei, Harri Rissanen, Harry Campbell, Heikki A. Koistinen, Helen R. Warren, Helena Schmidt, Henning Tiemeier, Hugoline G. de Haan, I Rudan, Ian Ford, Ian J. Deary, Igor Rudan, IJ Deary, Ilaria Gandin, Ilja Demuth, Ilja M. Nolte, Inga Patarcic, Inga Prokopenko, Ingrid B. Borecki, Irina Gillham-Nasenya, J Gibson, J. Wouter Jukema, Jaakko Kaprio, Jaakko Tuomilehto, James B. Meigs, James F. Wilson, James G. Wilson, James S. Pankow, Jari Lahti, Jaspal S. Kooner, JE Powell, Jeffrey R. O'Connel, Jennifer A. Smith, Jennifer E. Huffman, Jerome I. Rotter, Jessica D. Faul, Jessica van Setten, JI Hoffman, Jie Yao, Jing Hua Zhao, Jinyan Huang, Joel N. Hirschhorn, Johan G. Eriksson, Johanna Kuusisto, John B. Whitfield, John C. Chambers, John Connell, John M. Starr, John R. B. Perry, Jonathan P. Bradfield, Josée Dupuis, Jouke-Jan Hottenga, JR Flynn, Juha Sinisalo, JV Neel, Karen L. Mohlke, Kari E. North, Kauko Heikkilä, Kent D. Taylor, Kirsi Pietilainen, Koichi Matsuda, Konstantin Strauch, KW Broman, L Ronnegard, L. Adrienne Cupples, LA Weiss, Lars Bertram, Lars Lind, Laura J. Scott, Lawrence F. Bielak, Lazaros Lataniotis, Leanne M. Hall, Lenore J. Launer, Lihua Wang, Lili Milani, Lisa R. Yanek, Lisbeth Carstensen, Loic Yengo, Lorraine Southam, Louis Pérusse, Luigi Ferrucci, LV Hedges, Lyn R. Griffiths, Lynda M. Rose, Lynne J. Hocking, M Kirin, M Soler Artigas, M. Arfan Ikram, MA Nalls, Maciej Tomaszewski, Mads Melbye, Magnus Johannesson, Manraj K. Kooner, Marcus Dörr, Margie J. Wright, Mari Nelis, Maria G. Stathopoulou, Maria Pina Concas, Marie Loh, Marilyn C. Cornelis, Marina Ciullo, Mario Pirastu, Marja-Liisa Lokki, Mark Abney, Mark J. Caulfield, Markku Laakso, Markku S. Nieminen, Markus Perola, Mary F. Feitosa, Massimo Mangino, Matthew A. Allison, Matthew J. Suderman, May E. Montasser, MC Keller, MC Keller, Melanie Waldenberger, Michael Boehnke, Michela Traglia, Michiaki Kubo, Mika Kähönen, Miles C. Benton, Misa Graff, Najaf Amin, Nancy L. Heard-Costa, Natalia Tšernikova, Naveed Sattar, Nazir M. Khan, NE Morton, Neil Poulter, Nele Friedrich, Nicholas D. Hastie, Nicholas G. Martin, Nicholas J. Timpson, Nicholas J. Wareham, Nicola Pirastu, Nicole Soranzo, Niek Verweij, Niina Eklund, Nikhil Tandon, Nilesh J. Samani, Nona Sotoodehnia, Nora Franceschini, Olga McLeod, Olli Raitakari, Omri Gottesman, Ozren Polašek, Panos Deloukas, Paolo Gasparini, Patricia A. Peyser, Patricia B. Munroe, Patrik K. E. Magnusson, Pau Navarro, Paul Knekt, Paul M. Ridker, Paul Redmond, Pedro Marques-Vidal, Pekka Jousilahti, Penelope A. Lind, Peter J. van der Most, Peter K. Joshi, Peter Kraft, Peter Sever, Peter Vollenweider, Philipp Koellinger, Philippe Froguel, Pim van der Harst, Pirro G. Hysi, R McQuillan, R McQuillan, R. Graham Barr, RA Scott, Rajiv Nadukuru, Rany M. Salem, Rasika A. Mathias, RE Marioni, RE Marioni, Reedik Mägi, Reinhold Schmidt, Richa Saxena, Richard H. Myers, Richard Rose, Richard S. Cooper, Robert A. Scott, Rodney A. Lea, Rona J. Strawbridge, Ruth J. F. Loos, S Purcell, S Wright, S Wright, Sailaja Vedantam, Saira S. Mirza, Sander W. van der Laan, Sandosh Padmanabhan, Sarah E. Harris, Sarah E. Medland, Sarah Wild, Sarju Ralhan, Satu Männistö, Sebastian E. Baumeister, Seyhan Yazar, Sharon L. R. Kardia, Sheila Ulivi, Shona M. Kerr, Sian-Tsun Tang, Smeeta Shrestha, Sonja I. Berndt, Stavroula Kanoni, Stefan Enroth, Stefania Cappellani, Stella Trompet, Stephan J. L. Bakker, Stephanie J. London, Stephanie J. Loomis, Stephen B. Ellis, Stephen J. Chanock, Stephen S. Rich, Steven C. Hunt, Struan F.A. Grant, Sudha Seshadri, Suraj S. Nongmaithem, Sven Bergmann, Tamara B. Harris, Tanguy Corre, Tarunveer S. Ahluwalia, Teresa Nutile, Terho Lehtimäki, Thomas Lumley, Thomas Meitinger, Thorkild I. A. Sørensen, Tian Liu, Tim D. Spector, Tim Kacprowski, Timothy M. Frayling, TJ Pemberton, Tonu Esko, Traci M. Bartz, Tugce Karaderi, Tuula Vasankari, Ulf Gyllensten, Ulman Lindenberger, Ulrich Broeckel, Uzma Afzal, Veikko Salomaa, Veronique Vitart, Vilmundur Gudnason, Walter R. Palmas, Wei Zhao, Weihua Meng, Weihua Zhang, William R. Scott, William Wentworth-Shields, Xiaofeng Zhu, Xiuqing Guo, Y.-D. Ida Chen, Ying Wu, Yingchang Lu, Yingleong Chan, Yoichiro Kamatani, YS Aulchenko, YS Aulchenko, Yukinori Okada, Yuning Chen, Zhaoming Wang, Åsa Johansson +401 morecore +13 more sourcesAssociation of Long Runs of Homozygosity With Alzheimer Disease Among African American Individuals [PDF]
, 2015 IMPORTANCE: Mutations in known causal Alzheimer disease (AD) genes account for only 1% to 3% of patients and almost all are dominantly inherited. Recessive inheritance of complex phenotypes can be linked to long (>1-megabase [Mb]) runs of homozygosity ...Baldwin, Clinton T., Barnes, Lisa L., Bennett, David A., Buxbaum, Joseph D., Byrd, Goldie S., Cantwell, Laura B., Cheng, Rong, Crane, Paul K., De Jager, Philip L., Ertekin-Taner, Nilufer, Evans, Denis, Fallin, M. Daniele, Farrer, Lindsay A., Foroud, Tatiana M., Ghani, Mahdi, Go, Rodney C. P., Goate, Alison M., Graff-Radford, Neill R., Green, Robert C., Griffith, Patrick A., Haines, Jonathan L., Hall, Kathleen S., Hendrie, Hugh, Jun, Gyungah, Kamboh, M. Ilyas, Kukull, Walter A., Larson, Eric B., Lee, Joseph H., Lin, Chiao-Feng, Logue, Mark, Lopez, Oscar L., Lunetta, Kathryn L., Manly, Jennifer J., Mayeux, Richard, Murrell, Jill R., Naj, Adam, Obisesan, Thomas O., Pericak-Vance, Margaret A., Raj, Towfique, Rajbhandary, Ruchita, Reitz, Christiane, Rogaeva, Ekaterina, Sato, Christine, Schellenberg, Gerard D., St. George-Hyslop, Peter, Valladares, Otto, Vardarajan, Badri Narayan, Wang, Li-San +47 morecore +1 more sourceGenome-Wide Assessment of Runs of Homozygosity and Estimates of Genomic Inbreeding in a Chinese Composite Pig Breed
Frontiers in Genetics, 2021 The primary purpose of the current study was to assess the genetic diversity, runs of homozygosity (ROH) and ROH islands in a Chinese composite pig and explore hotspot regions for traces of selection. First, we estimated the length, number, and frequency Zhong Xu, Shuqi Mei, Jiawei Zhou, Yu Zhang, Mu Qiao, Hua Sun, Zipeng Li, Lianghua Li, Binke Dong, Favour Oluwapelumi Oyelami, Junjing Wu, Xianwen Peng +11 moredoaj +1 more source
