Results 31 to 40 of about 7,051 (240)
Ancestry-Dependent Enrichment of Deleterious Homozygotes in Runs of Homozygosity [PDF]
The American Journal of Human Genetics, 2018 Abstract Runs of homozygosity (ROH) are important genomic features that manifest when an individual inherits two haplotypes that are identical-by-descent. Their length distributions are informative about population history, and their genomic locations are useful for mapping recessive loci contributing to both Mendelian and complex ...
Szpiech, Zachary A. +6 more
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Runs of homozygosity and distribution of functional variants in the cattle genome [PDF]
BMC Genomics, 2015 Recent developments in sequencing technology have facilitated widespread investigations of genomic variants, including continuous stretches of homozygous genomic regions. For cattle, a large proportion of these runs of homozygosity (ROH) are likely the result of inbreeding due to the accumulation of elite alleles from long-term selective breeding ...
Zhang, Qianqian +4 more
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AutoMap is a high performance homozygosity mapping tool using next-generation sequencing data
Nature Communications, 2021 Homozygosity mapping is a useful tool for identifying candidate mutations in recessive conditions, however application to next generation sequencing data has been sub-optimal.
Mathieu Quinodoz +15 more
doaj +1 more source
Canine Medicine and Genetics, 2020 Background The calculation of demographic measures is a useful tool for evaluating the genomic architecture of dog breeds and enables ranking dog breeds in terms of genetic diversity.
Danae Vasiliadis +2 more
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Associations of genome-wide and regional autozygosity with 96 complex traits in old order Amish
BMC Genomics, 2023 Background: Autozygosity, the proportion of the genome that is homozygous by descent, has been associated with variation in multiple health-related traits impacting evolutionary fitness. Autozygosity (FROH) is typically measured from runs of homozygosity
Megan T. Lynch +6 more
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Analyzing Runs of Homozygosity Reveals Patterns of Selection in German Brown Cattle [PDF]
GenesKay-Uwe Gotz +2 more
exaly +2 more sources
Frontiers in Genetics, 2021 The primary purpose of the current study was to assess the genetic diversity, runs of homozygosity (ROH) and ROH islands in a Chinese composite pig and explore hotspot regions for traces of selection. First, we estimated the length, number, and frequency
Zhong Xu +11 more
doaj +1 more source
Runs of homozygosity are associated with staging of periodontitis in isolated populations
Human Molecular Genetics, 2021 AbstractPeriodontitis is a common inflammatory disease characterized by a complex etiology, which is the result of a combination of genetic and environmental factors. Genetic variants linked to the periodontitis disease were already investigated, however, little was known regarding the severity of this disease. Recently, long runs of homozygosity (ROH)
Mezzavilla M. +5 more
openaire +4 more sources
Genetics of consanguinity and inbreeding in health and disease
Annals of Human Biology, 2017 Context: Inbreeding increases the level of homozygotes for autosomal recessive disorders and is the major objective in clinical studies. The prevalence of consanguinity and the degree of inbreeding vary from one population to another depending on ...
Mohd Fareed, Mohammad Afzal
doaj +1 more source
GENOMIC BACKGROUND OF ENTROPION IN FLECKVIEH CATTLE [PDF]
Poljoprivreda, 2015 Runs of homozygosity (ROH) and genome wide association study (GWAS) were used to identify genomic regions of entropion in Austrian Fleckvieh cattle. Entropion is an eye disorder where the eye lids turn inward, causing inflammations, cornea damage or even
Gábor Mészáros +3 more
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