Results 31 to 40 of about 8,739 (269)

Examination of runs of homozygosity in relation to height in an endogamous Namibian population [PDF]

, 2023
OBJECTIVES: Height is a complex, highly heritable polygenic trait subject to both genetic composition and environmental influences. Recent studies suggest that a large proportion of height heritability is determined by the cumulative effect of many low ...
Lin, Meng, Brenna M. Henn, Henn, Brenna M, Meng Lin, Swinford, Natalie, Brenna Gallagher, Prall, Sean, Sheehama, Jacob, Natalie Swinford, Jacob Sheehama, Scelza, Brooke, Brooke Scelza, Sean Prall, Gallagher, Brenna   +13 more
core   +1 more source

Cooperative Genome-Wide Analysis Shows Increased Homozygosity in Early Onset Parkinson's Disease [PDF]

, 2012
Parkinson's disease (PD) occurs in both familial and sporadic forms, and both monogenic and complex genetic factors have been identified. Early onset PD (EOPD) is particularly associated with autosomal recessive (AR) mutations, and three genes, PARK2 ...
Heutink, Peter, Nicholas W. Wood (49276), Kilarski, Laura, Simon-Sanchez, J, Schulte, C., Heutink, P., John Hardy (23295), Morris, HR, Hardy, John, Andrew B. Singleton (178128), Laura L Kilarski, Conso, IPDG, Holmans, Peter, Holmans, P., Laura L. Kilarski (178120), John Hardy, Kilarski, Laura L., Hardy, J, Javier Simón-Sánchez (178117), Maria Martinez (87313), Schulte, Claudia, Singleton, Andrew B., Simon-Sanchez, J., Claudia Schulte, Hardy, J., International Parkinson's Disease Genomics Consortium, Kilarski, LL, Maria Martinez, Morris, H.R., Thomas Gasser, Andrew B Singleton, Nigel Williams (178133), Brown, Matthew, Brice, A, Thomas Gasser (33499), Peter Heutink, Williams, Nigel, Morris, Huw Rees, Holmans, P, Alexis Brice, Singleton, AB, Martinez, M., Kilarski, L.L., Gasser, T., Martinez, M, Gasser, T, Singleton, A.B., Claudia Schulte (125865), Nalls, MA, Holmans, Peter Alan, Nalls, M.A., Williams, N., Peter Holmans (28936), Javier Simón-Sánchez, Wood, NW, Nalls, Michael A., Schulte, C, Peter Holmans, Alexis Brice (41775), Peter Heutink (39587), Heutink, P, Wood, Nicholas W., Morris, Huw R., Williams, Nigel Melville, Brice, Alexis, Nicholas W Wood, Simon-Sanchez, Javier, Nigel Williams, Huw R. Morris (139451), Brice, A., Martinez, Maria, Michael A Nalls, Williams, N, Michael A. Nalls (113680), Wood, N.W., Wellcome Trust Case Control Consortium, Consor, WTCC, Gasser, Thomas, Huw R Morris   +78 more
core   +1 more source

Signatures of selection in the genome of Swedish warmblood horses selected for sport performance

BMC Genomics, 2019
Background A growing demand for improved physical skills and mental attitude in modern sport horses has led to strong selection for performance in many warmblood studbooks.
Michela Ablondi, Åsa Viklund, Gabriella Lindgren, Susanne Eriksson, Sofia Mikko   +4 more
doaj   +1 more source

Runs of homozygosity and a cluster of vulvar cancer in young Australian Aboriginal women [PDF]

, 2014
Objective A cluster of vulvar cancer exists in young Aboriginal women living in remote communities in Arnhem Land, Australia. A genetic case-control study was undertaken involving 30 cases of invasive vulvar cancer and its precursor lesion, high-grade ...
Dickinson, J., Thomson, Russell J., Dickinson, Joanne L., McWhirter, R., Marthick, J., Rumbold, A., Marthick, James R., Taylor-Thomson, Debbie, Maypilama, E., Condon, John R., Mcwhirter, Rebekah E., Brown, Matthew A., Thomson, R., Taylor-Thomson, D., Rumbold, Alice R., Condon, J., Brown, M., Maypilama, Elaine L., Thomson, Russell J. (R18461)   +18 more
core   +3 more sources

Long Runs of Homozygosity Are Enriched for Deleterious Variation [PDF]

The American Journal of Human Genetics, 2013
Exome sequencing offers the potential to study the population-genomic variables that underlie patterns of deleterious variation. Runs of homozygosity (ROH) are long stretches of consecutive homozygous genotypes probably reflecting segments shared identically by descent as the result of processes such as consanguinity, population size reduction, and ...
Szpiech, Zachary A., Xu, Jishu, Pemberton, Trevor J., Peng, Weiping, Zöllner, Sebastian, Rosenberg, Noah A., Li, Jun Z.   +6 more
openaire   +2 more sources

Descriptive statistics for inbreeding coefficients (number of runs of homozygosity (ROHs) and proportion of genome in runs of homozygosity (F_roh)). [PDF]

, 2014
Descriptive statistics for inbreeding coefficients (number of runs of homozygosity (ROHs) and proportion of genome in runs of homozygosity (Froh)).
Marjo-Riitta Järvelin (2141947), Brendan P. Zietsch (298834), Abdel Abdellaoui (109742), Matthew C. Keller (171356), Juha Veijola (150307), Sylvain Sebert (159293), Karin J. H. Verweij (127165), Markku Koiranen (150288)   +7 more
core   +1 more source

Runs of homozygosity and signatures of selection: a comparison among eight local Swiss sheep breeds. [PDF]

, 2019
A dataset consisting of 787 animals with high-density SNP chip genotypes (346 774 SNPs) and 939 animals with medium-density SNP chip genotypes (33 828 SNPs) from eight indigenous Swiss sheep breeds was analyzed to characterize population structure ...
Burren, Alexander, Flury, C, Flury, Christine, A. Burren, Burren, A, Ammann, P., C. Drögemüller, Ammann, P, C. Flury, Drögemüller, Cord, Signer-Hasler, Heidi, H. Signer‐Hasler, P. Ammann, Drögemüller, C.   +13 more
core   +1 more source

AutoMap is a high performance homozygosity mapping tool using next-generation sequencing data

Nature Communications, 2021
Homozygosity mapping is a useful tool for identifying candidate mutations in recessive conditions, however application to next generation sequencing data has been sub-optimal.
Mathieu Quinodoz, Virginie G. Peter, Nicola Bedoni, Béryl Royer Bertrand, Katarina Cisarova, Arash Salmaninejad, Neda Sepahi, Raquel Rodrigues, Mehran Piran, Majid Mojarrad, Alireza Pasdar, Ali Ghanbari Asad, Ana Berta Sousa, Luisa Coutinho Santos, Andrea Superti-Furga, Carlo Rivolta   +15 more
doaj   +1 more source

Ancestry-Dependent Enrichment of Deleterious Homozygotes in Runs of Homozygosity [PDF]

The American Journal of Human Genetics, 2018
Abstract Runs of homozygosity (ROH) are important genomic features that manifest when an individual inherits two haplotypes that are identical-by-descent. Their length distributions are informative about population history, and their genomic locations are useful for mapping recessive loci contributing to both Mendelian and complex ...
Szpiech, Zachary A., Mak, Angel C.Y., White, Marquitta J., Hu, Donglei, Eng, Celeste, Burchard, Esteban G., Hernandez, Ryan D.   +6 more
openaire   +4 more sources

Runs of Homozygosity Islands in Autochthonous Spanish Cattle Breeds. [PDF]

Genes (Basel)
Background/Objectives: Understanding the genetic architecture of autochthonous European cattle breeds is important for developing effective conservation strategies and sustainable breeding programs. Spanish beef cattle, which trace their origins to ancient migrations from the Near East with later admixture from African populations, exhibit a rich ...
Hervás-Rivero C, Mejuto-Vázquez N, López-Carbonell D, Altarriba J, Diaz C, Molina A, Rodríguez-Bermúdez R, Piedrafita J, Baro JA, Varona L.   +9 more
europepmc   +9 more sources