Results 31 to 40 of about 167,442,745 (268)

Runs of Homozygosity and Inferences in Wild Populations. [PDF]

Mol Ecol
Long homozygous chromosome segments are known as runs of homozygosity (ROH); these reflect patterns of identity by descent and can be used to measure individual inbreeding, map recessive traits, and reconstruct demographic histories. Here we review some key considerations with ROH detection and the inferences pertaining to inbreeding and demographic ...
Shafer ABA, Kardos M.
europepmc   +3 more sources

Ethnic Identity and Genome Wide Runs of Homozygosity [PDF]

Behavior Genetics, 2021
AbstractIt is long known that inbreeding increases the detrimental effects of recessive sequence variants in “Runs of Homozygosity” (ROHs). However, although the phenotypic association of ROH has been investigated for a variety of traits, the statistical power of the results often remains limited as a sufficiently high number of cases are available for
Fieder, Martin, Mitchell, Brittany L., Gordon, Scott, Huber, Susanne, Martin, Nicholas G.   +4 more
openaire   +7 more sources

Facial attractiveness is only weakly linked to genome–wide heterozygosity

Frontiers in Psychology, 2023
IntroductionIt has been frequently suggested that overall genomic heterozygosity and, particularly, heterozygosity of loci on the so-called major histocompatibility complex (MHC), which is responsible for the recognition of foreign substances/ pathogens ...
Martin Fieder, Martin Fieder, Susanne Huber   +2 more
doaj   +1 more source

Heterozygosity and homozygosity regions affect reproductive success and the loss of reproduction: A case study with litter traits in pigs

Computational and Structural Biotechnology Journal, 2022
Runs of heterozygosity (ROHet) and homozygosity (ROH) harbor useful information related to traits of interest. There is a lack of investigating the effect of ROHet and ROH on reproductive success and the loss of reproduction in mammals. Here, we detected
Zitao Chen, Zhenyang Zhang, Zhen Wang, Zhe Zhang, Qishan Wang, Yuchun Pan   +5 more
doaj   +1 more source

Correlation of Genomic and Pedigree Inbreeding Coefficients in Small Cattle Populations

Animals, 2021
This study aimed to identify inbreeding coefficient (F) estimators useful for improvement programs in a small Holstein population through the evaluation of different methodologies in the Mexican Holstein population.
José Cortes-Hernández, Adriana García-Ruiz, Carlos Gustavo Vásquez-Peláez, Felipe de Jesus Ruiz-Lopez   +3 more
doaj   +1 more source

The effects of runs-of-homozygosity on pig domestication and breeding. [PDF]

BMC Genomics
Since their domestication, recent inbreeding together with intensive artificial selection and population bottlenecks have allowed the prevalence of deleterious mutations and the increase of runs-of-homozygosity (ROH) in domestic pigs. This makes pigs a good model to understand the genetic underpinnings of inbreeding depression.Here we integrated a ...
Tao L, Liu H, Adeola AC, Xie HB, Feng ST, Zhang YP.   +5 more
europepmc   +4 more sources

Runs of homozygosity in Worldwide cattle breeds

, 2022
Data supporting the findings of the paper "Analysis of Runs of Homozygosity of cattle living in different climate zones " in Animal ...
Cesarani, A
core   +2 more sources

Genome-wide analysis of runs of homozygosity in Italian Mediterranean buffalo

Journal of Dairy Science, 2022
: Runs of homozygosity (ROH) are a powerful tool to explore patterns of genomic inbreeding in animal populations and detect signatures of selection. The present study used ROH analysis to evaluate the genome-wide patterns of homozygosity, inbreeding ...
Shen-he Liu, Xiao-ya Ma, Faiz-ul Hassan, Teng-yun Gao, Ting-xian Deng   +4 more
doaj   +1 more source

Runs of homozygosity and inbreeding in thyroid cancer [PDF]

BMC Cancer, 2016
Genome-wide association studies (GWASs) have identified several single-nucleotide polymorphisms (SNPs) influencing the risk of thyroid cancer (TC). Most cancer predisposition genes identified through GWASs function in a co-dominant manner, and studies have not found evidence for recessively functioning disease loci in TC.
Thomsen H, Chen B, Figlioli G, ELISEI, ROSSELLA, ROMEI, CRISTINA, CIPOLLINI, MONICA, CRISTAUDO, ALFONSO, Bambi F, Hoffmann P, Herms S, LANDI, STEFANO, Hemminki K, GEMIGNANI, FEDERICA, Försti A.   +13 more
openaire   +3 more sources

Cooperative Genome-Wide Analysis Shows Increased Homozygosity in Early Onset Parkinson's Disease [PDF]

, 2012
Parkinson's disease (PD) occurs in both familial and sporadic forms, and both monogenic and complex genetic factors have been identified. Early onset PD (EOPD) is particularly associated with autosomal recessive (AR) mutations, and three genes, PARK2 ...
Heutink, Peter, Nicholas W. Wood (49276), Kilarski, Laura, Simon-Sanchez, J, Schulte, C., Heutink, P., John Hardy (23295), Morris, HR, Hardy, John, Andrew B. Singleton (178128), Laura L Kilarski, Conso, IPDG, Holmans, Peter, Holmans, P., Laura L. Kilarski (178120), John Hardy, Kilarski, Laura L., Hardy, J, Javier Simón-Sánchez (178117), Maria Martinez (87313), Schulte, Claudia, Singleton, Andrew B., Simon-Sanchez, J., Claudia Schulte, Hardy, J., International Parkinson's Disease Genomics Consortium, Kilarski, LL, Maria Martinez, Morris, H.R., Thomas Gasser, Andrew B Singleton, Nigel Williams (178133), Brown, Matthew, Brice, A, Thomas Gasser (33499), Peter Heutink, Williams, Nigel, Morris, Huw Rees, Holmans, P, Alexis Brice, Singleton, AB, Martinez, M., Kilarski, L.L., Gasser, T., Martinez, M, Gasser, T, Singleton, A.B., Claudia Schulte (125865), Nalls, MA, Holmans, Peter Alan, Nalls, M.A., Williams, N., Peter Holmans (28936), Javier Simón-Sánchez, Wood, NW, Nalls, Michael A., Schulte, C, Peter Holmans, Alexis Brice (41775), Peter Heutink (39587), Heutink, P, Wood, Nicholas W., Morris, Huw R., Williams, Nigel Melville, Brice, Alexis, Nicholas W Wood, Simon-Sanchez, Javier, Nigel Williams, Huw R. Morris (139451), Brice, A., Martinez, Maria, Michael A Nalls, Williams, N, Michael A. Nalls (113680), Wood, N.W., Wellcome Trust Case Control Consortium, Consor, WTCC, Gasser, Thomas, Huw R Morris   +78 more
core   +2 more sources