Results 41 to 50 of about 7,051 (240)

Runs of Homozygosity Revealed Reproductive Traits of Hu Sheep

Genes, 2022
Hu sheep, a famous breed in the Taihu Basin, has the advantages of non-seasonal estrus, multiple fetuses, coarse feeding tolerance, and suitability for house feeding. Runs of homozygosity (ROHs) were found to be an effective tool to detect the animal population structure and economic traits.
Yuzhe Li, Zitao Chen, Yifei Fang, Caiyun Cao, Zhe Zhang, Yuchun Pan, Qishan Wang   +6 more
openaire   +2 more sources

Optimizing genetic diversity in Australian Holsteins and Jerseys: A comparative analysis of whole-genome and regional inbreeding depression effects

Journal of Dairy Science
: Homozygosity, which can arise from several genetic mechanisms including inbreeding, is frequently observed in the offspring of related parents. This inbreeding can lead to a reduced performance, owing to a phenomenon known as inbreeding depression ...
B.A. Scott, M. Haile-Mariam, F. Tiezzi, I. van den Berg, C. Maltecca, J.E. Pryce   +5 more
doaj   +1 more source

Genomic characterization of autozygosity and recent inbreeding trends in all major breeds of US dairy cattle

Journal of Dairy Science, 2022
: Maintaining a genetically diverse dairy cattle population is critical to preserving adaptability to future breeding goals and avoiding declines in fitness.
Emmanuel A. Lozada-Soto, Francesco Tiezzi, Jicai Jiang, John B. Cole, Paul M. VanRaden, Christian Maltecca   +5 more
doaj   +1 more source

Genome-wide detection for runs of homozygosity analysis in three pig breeds from Chinese Taihu Basin and Landrace pigs by SLAF-seq data

Journal of Integrative Agriculture, 2022
Erhualian (E), Meishan (MS) and Mi (MI) pigs are excellent indigenous pig breeds in Chinese Taihu Basin, which have made great contributions to the genetic improvement of commercial pigs. Investigation of the genetic structure and inbreeding level of the
Shi-feng TONG, Mo ZHU, Rui XIE, Dong-feng LI, Li-fan ZHANG, Yang LIU   +5 more
doaj   +1 more source

Inbreeding depression affecting stayability in Italian Holstein cows

Journal of Dairy Science
: Advances in selection and reproduction methods, particularly the implementation of genomic evaluations alongside assisted reproductive technologies, have substantially enhanced productivity and efficiency, notably within specialized dairy cattle ...
J.C.C. Panetto, C. Maltecca, M. Ablondi, S. Callegaro, J-T. van Kaam, R. Finocchiaro, A. Fabris, M.C. Fabbri, M. Cassandro, C. Cipolat-Gotet, A. Zanotti, R. Bozzi, F. Tiezzi   +12 more
doaj   +1 more source

The Role of “Adult‐Onset” Cancer Predisposition Genes in Pediatric Cancer: A Comprehensive Review

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Current literature estimates that 10% of pediatric cancers are caused by pathogenic or likely pathogenic (P/LP) germline variants in cancer predisposition genes (CPGs). Variants in CPGs thought to increase cancer risk exclusively during adulthood are referred to as “adult‐onset” CPGs (aoCPGs).
Maria Rozo, Miriam A. Bornhorst, Angela J. Waanders, Sara Zarnegar‐Lumley, Ashwin Lakshman Koppayi, Lucy A. Godley   +5 more
wiley   +1 more source

Multi-trait meta-analyses reveal 25 quantitative trait loci for economically important traits in Brown Swiss cattle

BMC Genomics, 2019
Background Little is known about the genetic architecture of economically important traits in Brown Swiss cattle because only few genome-wide association studies (GWAS) have been carried out in this breed.
Zih-Hua Fang, Hubert Pausch
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source