Results 41 to 50 of about 8,739 (269)

Runs of homozygosity and distribution of functional variants in the cattle genome [PDF]

BMC Genomics, 2015
Recent developments in sequencing technology have facilitated widespread investigations of genomic variants, including continuous stretches of homozygous genomic regions. For cattle, a large proportion of these runs of homozygosity (ROH) are likely the result of inbreeding due to the accumulation of elite alleles from long-term selective breeding ...
Zhang, Qianqian, Guldbrandtsen, Bernt, Bosse, Mirte, Lund, Mogens S., Sahana, Goutam   +4 more
openaire   +5 more sources

Demographic assessment of the Dalmatian dog – effective population size, linkage disequilibrium and inbreeding coefficients

Canine Medicine and Genetics, 2020
Background The calculation of demographic measures is a useful tool for evaluating the genomic architecture of dog breeds and enables ranking dog breeds in terms of genetic diversity.
Danae Vasiliadis, Julia Metzger, Ottmar Distl   +2 more
doaj   +1 more source

Associations of genome-wide and regional autozygosity with 96 complex traits in old order Amish

BMC Genomics, 2023
Background: Autozygosity, the proportion of the genome that is homozygous by descent, has been associated with variation in multiple health-related traits impacting evolutionary fitness. Autozygosity (FROH) is typically measured from runs of homozygosity
Megan T. Lynch, Kristin A. Maloney, Huichun Xu, James A. Perry, Regeneron Genetics Center, Alan R. Shuldiner, Braxton D. Mitchell   +6 more
doaj   +1 more source

Runs of homozygosity are associated with staging of periodontitis in isolated populations

Human Molecular Genetics, 2021
AbstractPeriodontitis is a common inflammatory disease characterized by a complex etiology, which is the result of a combination of genetic and environmental factors. Genetic variants linked to the periodontitis disease were already investigated, however, little was known regarding the severity of this disease. Recently, long runs of homozygosity (ROH)
Mezzavilla M., Navarra C. O., Di Lenarda R., Gasparini P., Bevilacqua L., Robino A.   +5 more
openaire   +4 more sources

Genome-Wide Assessment of Runs of Homozygosity and Estimates of Genomic Inbreeding in a Chinese Composite Pig Breed

Frontiers in Genetics, 2021
The primary purpose of the current study was to assess the genetic diversity, runs of homozygosity (ROH) and ROH islands in a Chinese composite pig and explore hotspot regions for traces of selection. First, we estimated the length, number, and frequency
Zhong Xu, Shuqi Mei, Jiawei Zhou, Yu Zhang, Mu Qiao, Hua Sun, Zipeng Li, Lianghua Li, Binke Dong, Favour Oluwapelumi Oyelami, Junjing Wu, Xianwen Peng   +11 more
doaj   +1 more source

Runs of homozygosity in killer whale genomes provide a global record of demographic histories [PDF]

, 2021
Runs of homozygosity (ROH) occur when offspring inherit haplotypes that are identical by descent from each parent. Length distributions of ROH are informative about population history; specifically, the probability of inbreeding mediated by mating system
Brownlow, Andrew, Robertson, Kelly, Laurent Excoffier, Andrew D. Foote, Paul Tixier, Paul Wade, Morin, Philiip A, Durban, John W., Dalla Rosa, Luciano, John A. Totterdell, Nicholas J. Davison, Barlow, Jay, Renaud de Stephanis, Forney, Karin A., Karin A. Forney, Gilbert, Marcus Thomas Pius, Alana Alexander, Robertson, Kelly M., Phillip A. Morin, Tim Gerrodette, Michael D. Martin, Wolf, Jochen B. W., Martin, Michael David, Baird, Robin, Sara B. Tavares, Jochen B. W. Wolf, Gerrodette, Tim, Samarra, Filipa I.P., Wade, Paul, Fan, Guangyi, Alexander, Alana, Baker, Charles Scott, Rosa, Luciano Dalla, M. Bradley Hanson, de Stephanis, Renaud, Luciano Dalla Rosa, Martin, Michael D., Sarah L. Fordyce Martin, Baird, Robin W., Stephanis, Renaud, Samarra, Filipa I. P., Andrew Brownlow, Tavares, Sara B., Rochelle Constantine, Baker, Scott, Constantine, Rochelle, Morin, Phillip A., Hooper, Rebecca, Guangyi Fan, Davison, Nicholas J., Guinet, Christophe, Esteban, Ruth, Totterdell, John A., Hanson, M. Bradley, Jay Barlow, Rebecca Hooper, Lisa Ballance, Christophe Guinet, John W. Durban, Robin W. Baird, Kelly M. Robertson, Excoffier, Laurent, Ruth Esteban, Collins, Tim, M. Thomas P. Gilbert, Martin, Sarah, Martin, Michael, Filipa I. P. Samarra, Ballance, Lisa, Fordyce Martin, Sarah L., Li, Songhai, Gilbert, M. Thomas P., Charles Scott Baker, Foote, Andrew D., Yaolei Zhang, Zhang, Yaolei, Foote, Andrew, Martin, Sarah L. Fordyce, Tim Collins, Wolf, Jochen B.W., Durban, John, Songhai Li, Tixier, Paul, Davison, Nicholas   +83 more
core   +1 more source

Runs of Homozygosity Revealed Reproductive Traits of Hu Sheep

Genes, 2022
Hu sheep, a famous breed in the Taihu Basin, has the advantages of non-seasonal estrus, multiple fetuses, coarse feeding tolerance, and suitability for house feeding. Runs of homozygosity (ROHs) were found to be an effective tool to detect the animal population structure and economic traits.
Yuzhe Li, Zitao Chen, Yifei Fang, Caiyun Cao, Zhe Zhang, Yuchun Pan, Qishan Wang   +6 more
openaire   +2 more sources

Methods for detection of runs of homozygosity (RoH) [PDF]

, 2021
The thesis deals with presence of runs of homozygosity, their origin and ways of their detection. Based on the analysis of two samples provided by the Institute of Neurology, University College London, we study differences in detection of runs of ...
Genči, Jakub
core  

GENOMIC BACKGROUND OF ENTROPION IN FLECKVIEH CATTLE [PDF]

Poljoprivreda, 2015
Runs of homozygosity (ROH) and genome wide association study (GWAS) were used to identify genomic regions of entropion in Austrian Fleckvieh cattle. Entropion is an eye disorder where the eye lids turn inward, causing inflammations, cornea damage or even
Gábor Mészáros, Martin Peter Stückler , Maja Ferenčaković, Johann Sölkner   +3 more
doaj   +1 more source

Genetics of consanguinity and inbreeding in health and disease

Annals of Human Biology, 2017
Context: Inbreeding increases the level of homozygotes for autosomal recessive disorders and is the major objective in clinical studies. The prevalence of consanguinity and the degree of inbreeding vary from one population to another depending on ...
Mohd Fareed, Mohammad Afzal
doaj   +1 more source