Results 41 to 50 of about 167,442,745 (268)

Signatures of selection in the genome of Swedish warmblood horses selected for sport performance

BMC Genomics, 2019
Background A growing demand for improved physical skills and mental attitude in modern sport horses has led to strong selection for performance in many warmblood studbooks.
Michela Ablondi, Åsa Viklund, Gabriella Lindgren, Susanne Eriksson, Sofia Mikko   +4 more
doaj   +1 more source

Examination of runs of homozygosity in relation to height in an endogamous Namibian population [PDF]

, 2023
OBJECTIVES: Height is a complex, highly heritable polygenic trait subject to both genetic composition and environmental influences. Recent studies suggest that a large proportion of height heritability is determined by the cumulative effect of many low ...
Lin, Meng, Brenna M. Henn, Henn, Brenna M, Meng Lin, Swinford, Natalie, Brenna Gallagher, Prall, Sean, Sheehama, Jacob, Natalie Swinford, Jacob Sheehama, Scelza, Brooke, Brooke Scelza, Sean Prall, Gallagher, Brenna   +13 more
core   +1 more source

Long Runs of Homozygosity Are Enriched for Deleterious Variation [PDF]

The American Journal of Human Genetics, 2013
Exome sequencing offers the potential to study the population-genomic variables that underlie patterns of deleterious variation. Runs of homozygosity (ROH) are long stretches of consecutive homozygous genotypes probably reflecting segments shared identically by descent as the result of processes such as consanguinity, population size reduction, and ...
Szpiech, Zachary A., Xu, Jishu, Pemberton, Trevor J., Peng, Weiping, Zöllner, Sebastian, Rosenberg, Noah A., Li, Jun Z.   +6 more
openaire   +2 more sources

Runs of homozygosity and signatures of selection: a comparison among eight local Swiss sheep breeds. [PDF]

, 2019
A dataset consisting of 787 animals with high-density SNP chip genotypes (346 774 SNPs) and 939 animals with medium-density SNP chip genotypes (33 828 SNPs) from eight indigenous Swiss sheep breeds was analyzed to characterize population structure ...
Burren, Alexander, Flury, C, Flury, Christine, A. Burren, Burren, A, Ammann, P., C. Drögemüller, Ammann, P, C. Flury, Drögemüller, Cord, Signer-Hasler, Heidi, H. Signer‐Hasler, P. Ammann, Drögemüller, C.   +13 more
core   +2 more sources

Ancestry-Dependent Enrichment of Deleterious Homozygotes in Runs of Homozygosity [PDF]

The American Journal of Human Genetics, 2018
Abstract Runs of homozygosity (ROH) are important genomic features that manifest when an individual inherits two haplotypes that are identical-by-descent. Their length distributions are informative about population history, and their genomic locations are useful for mapping recessive loci contributing to both Mendelian and complex ...
Szpiech, Zachary A., Mak, Angel C.Y., White, Marquitta J., Hu, Donglei, Eng, Celeste, Burchard, Esteban G., Hernandez, Ryan D.   +6 more
openaire   +4 more sources

Associations of genome-wide and regional autozygosity with 96 complex traits in old order Amish

BMC Genomics, 2023
Background: Autozygosity, the proportion of the genome that is homozygous by descent, has been associated with variation in multiple health-related traits impacting evolutionary fitness. Autozygosity (FROH) is typically measured from runs of homozygosity
Megan T. Lynch, Kristin A. Maloney, Huichun Xu, James A. Perry, Regeneron Genetics Center, Alan R. Shuldiner, Braxton D. Mitchell   +6 more
doaj   +1 more source

Runs of homozygosity and distribution of functional variants in the cattle genome [PDF]

BMC Genomics, 2015
Recent developments in sequencing technology have facilitated widespread investigations of genomic variants, including continuous stretches of homozygous genomic regions. For cattle, a large proportion of these runs of homozygosity (ROH) are likely the result of inbreeding due to the accumulation of elite alleles from long-term selective breeding ...
Zhang, Qianqian, Guldbrandtsen, Bernt, Bosse, Mirte, Lund, Mogens S., Sahana, Goutam   +4 more
openaire   +5 more sources

Demographic assessment of the Dalmatian dog – effective population size, linkage disequilibrium and inbreeding coefficients

Canine Medicine and Genetics, 2020
Background The calculation of demographic measures is a useful tool for evaluating the genomic architecture of dog breeds and enables ranking dog breeds in terms of genetic diversity.
Danae Vasiliadis, Julia Metzger, Ottmar Distl   +2 more
doaj   +1 more source

Runs of homozygosity are associated with staging of periodontitis in isolated populations

Human Molecular Genetics, 2021
AbstractPeriodontitis is a common inflammatory disease characterized by a complex etiology, which is the result of a combination of genetic and environmental factors. Genetic variants linked to the periodontitis disease were already investigated, however, little was known regarding the severity of this disease. Recently, long runs of homozygosity (ROH)
Mezzavilla M., Navarra C. O., Di Lenarda R., Gasparini P., Bevilacqua L., Robino A.   +5 more
openaire   +4 more sources

IDENTIFICATION OF DISEASE GENES FOR RARE AUTOSOMAL RECESSIVE EPILEPTIC SYNDROMES BY HOMOZYGOSITY MAPPING [PDF]

, 2011
Introduction: The genetics of the most common neurological disorders, including epilepsy, with mendelian inheritance has been dissected in the last twenty years. However the genetic etiology of some rare epileptic conditions is still unknown.
Coppola, Antonietta
core   +1 more source