Results 21 to 30 of about 7,051 (240)

The effects of runs-of-homozygosity on pig domestication and breeding. [PDF]

BMC Genomics
Since their domestication, recent inbreeding together with intensive artificial selection and population bottlenecks have allowed the prevalence of deleterious mutations and the increase of runs-of-homozygosity (ROH) in domestic pigs. This makes pigs a good model to understand the genetic underpinnings of inbreeding depression.Here we integrated a ...
Tao L, Liu H, Adeola AC, Xie HB, Feng ST, Zhang YP.   +5 more
europepmc   +4 more sources

Genomic prediction based on runs of homozygosity [PDF]

Genetics Selection Evolution, 2014
Genomic prediction is based on the accurate estimation of the genomic relationships among and between training animals and selection candidates in order to obtain accurate estimates of the genomic estimated breeding values (GEBV). Various methods have been used to predict GEBV based on population-wide linkage disequilibrium relationships (G IBS ) or ...
Luan, Tu, Yu, Xijiang, Dolezal, Marlies, Bagnato, Alessandro, Meuwissen, Theo He   +4 more
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Runs of homozygosity and testicular cancer risk [PDF]

Andrology, 2019
AbstractBackgroundTesticular germ cell tumour (TGCT) is highly heritable but > 50% of the genetic risk remains unexplained. Epidemiological observation of greater relative risk to brothers of men with TGCT compared to sons has long alluded to recessively acting TGCT genetic susceptibility factors, but to date none have been reported.
Loveday, C., Sud, A., Litchfield, K., Levy, M., Holroyd, A., Broderick, P., Kote-Jarai, Z., Dunning, A.M., Muir, K., Peto, J., Eeles, R., Easton, D.F., Dudakia, D., Orr, N., Pashayan, N., Rustin, Gordon, Srihari, Narayanan N., Cole, David, Askill, Colin, Bertelli, Gianfilippo, Barber, James, Gilby, Ed, White, Jeff, Baybrooke, Jeremy, Leahy, Michael, Welch, Richard, Chakraborti, Prabir, Joffe, Johnathan, Brown, Richard, Faust, Guy, Simmonds, Peter, Mazhar, Danish, Stockdale, Andrew, Hrounda, David, Humber, Caroline, Appel, Wiebke, Hong, Anne, Howard, Grahame, Douglas, Fiona, Bloomfield, David, Butt, Mohammad, Kelly, Kay, Mehra, Rakesh, Brown, Richard, Rogers, Paul, Chakraborti, Prabir, Hatton, Matthew, Hennig, Ivo, McAteer, John, Savage, Philip, Seckl, Michael, Gale, Joanna, Rustin, Gordon, Clark, Peter, Woby, Steve, Rathmell, Adrian, Lamont, Alan, Sarwar, Naveed, Stuart, Nick, Chowdhury, Simon, Beesley, Sharon, Winkler, Mathius, Hamid, Abdel, Pathak, Sanjeev, Madhavan, Krishnaswamy, Highley, Martin, Money-Kryle, Julian, Brock, Cathryn, Sreenivasan, Thiagarajan, Henderson, Brian E., Haiman, Christopher A., Schumacher, Fredrick R., Al Olama, Ali Amin, Benlloch, Sara, Berndt, Sonja I., Conti, David V., Wiklund, Fredrik, Chanock, Stephen, Gapster, Susan, Stevens, Victoria L., Tangen, Catherine M., Batra, Jyotsna, Clements, Judith, Gronberg, Henrik, Schleutker, Johanna, Albanes, Demetrius, Wolk, Alicja, West, Catharine, Mucci, Lorelei, Cancel-Tassin, Geraldine, Koutros, Stella, Sorensen, Karina Dalsgaard, Maehle, Lovise, Neal, David E., Hamdy, Freddie C., Donovan, Jenny L., Travis, Ruth C., Hamilton, Robert J., Ingles, Sue Ann, Rosenstein, Barry S., Lu, Yong-Jie, Giles, Graham G., Kibel, Adam S., Vega, Ana, Kogevinas, Manolis, Penney, Kathryn L., Park, Jong Y., Stanford, Janet L., Cybulski, Cezary, Nordestgaard, Borge G., Brenner, Hermann, Maier, Christiane, Kim, Jeri, John, Esther M., Teixeira, Manuel R., Neuhausen, Susan L., De Ruyck, Kim, Razack, Azad, Newcomb, Lisa F., Lessel, Davor, Kaneva, Radka, Usmani, Nawaid, Claessens, Frank, Townsend, Paul A., Dominguez, Manuela Gago, Roobol, Monique J., Menegaux, Florence, Khaw, Kay-Tee, Cannon-Albrigh, Lisa, Pandha, Hardev, Thibodeau, Stephen N., Reid, A., Huddart, R.A., Houlston, R.S., Turnbull, C.   +134 more
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Genome-wide analysis of runs of homozygosity in Italian Mediterranean buffalo

Journal of Dairy Science, 2022
: Runs of homozygosity (ROH) are a powerful tool to explore patterns of genomic inbreeding in animal populations and detect signatures of selection. The present study used ROH analysis to evaluate the genome-wide patterns of homozygosity, inbreeding ...
Shen-he Liu, Xiao-ya Ma, Faiz-ul Hassan, Teng-yun Gao, Ting-xian Deng   +4 more
doaj   +1 more source

Runs of homozygosity and inbreeding in thyroid cancer [PDF]

BMC Cancer, 2016
Genome-wide association studies (GWASs) have identified several single-nucleotide polymorphisms (SNPs) influencing the risk of thyroid cancer (TC). Most cancer predisposition genes identified through GWASs function in a co-dominant manner, and studies have not found evidence for recessively functioning disease loci in TC.
Thomsen H, Chen B, Figlioli G, ELISEI, ROSSELLA, ROMEI, CRISTINA, CIPOLLINI, MONICA, CRISTAUDO, ALFONSO, Bambi F, Hoffmann P, Herms S, LANDI, STEFANO, Hemminki K, GEMIGNANI, FEDERICA, Försti A.   +13 more
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Genomic Diversity and Runs of Homozygosity in Bernese Mountain Dogs [PDF]

Genes, 2023
Bernese mountain dogs are a large dog breed formed in the early 1900s in Switzerland. While originally farm dogs that were used for pulling carts, guarding, and driving cattle, today they are considered multi-purpose companion and family dogs. The breed is predisposed to several complex diseases, such as histiocytic sarcoma, degenerative myelopathy, or
Anna Letko, Benoît Hédan, Anna Snell, Alexander C. Harris, Vidhya Jagannathan, Göran Andersson, Bodil S. Holst, Elaine A. Ostrander, Pascale Quignon, Catherine André, Tosso Leeb   +10 more
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Signatures of selection in the genome of Swedish warmblood horses selected for sport performance

BMC Genomics, 2019
Background A growing demand for improved physical skills and mental attitude in modern sport horses has led to strong selection for performance in many warmblood studbooks.
Michela Ablondi, Åsa Viklund, Gabriella Lindgren, Susanne Eriksson, Sofia Mikko   +4 more
doaj   +1 more source

Estimation of inbreeding in Ethiopia goats using runs of homozygosity

Acta Fytotechnica et Zootechnica, 2017
This study was carried out to estimate the inbreeding levels in Abergelle, Gumuz, Keffa and Woytoguji goats in Ethiopia from genomic information. A total of 161 animals (53 Abergelle, 39 Gumuz, 31 Keffa and 38 Woytoguji) were genotyped using the Illumina
Wilson Nandolo , Maria Wurzinger, Gábor Mészáros et al.   +2 more
doaj   +1 more source

Long Runs of Homozygosity Are Enriched for Deleterious Variation [PDF]

The American Journal of Human Genetics, 2013
Exome sequencing offers the potential to study the population-genomic variables that underlie patterns of deleterious variation. Runs of homozygosity (ROH) are long stretches of consecutive homozygous genotypes probably reflecting segments shared identically by descent as the result of processes such as consanguinity, population size reduction, and ...
Szpiech, Zachary A., Xu, Jishu, Pemberton, Trevor J., Peng, Weiping, Zöllner, Sebastian, Rosenberg, Noah A., Li, Jun Z.   +6 more
openaire   +2 more sources

Runs of Homozygosity Islands in Autochthonous Spanish Cattle Breeds. [PDF]

Genes (Basel)
Background/Objectives: Understanding the genetic architecture of autochthonous European cattle breeds is important for developing effective conservation strategies and sustainable breeding programs. Spanish beef cattle, which trace their origins to ancient migrations from the Near East with later admixture from African populations, exhibit a rich ...
Hervás-Rivero C, Mejuto-Vázquez N, López-Carbonell D, Altarriba J, Diaz C, Molina A, Rodríguez-Bermúdez R, Piedrafita J, Baro JA, Varona L.   +9 more
europepmc   +9 more sources