Results 21 to 30 of about 8,739 (269)
Estimates of autozygosity through runs of homozygosity in farmed coho salmon [PDF]
Genes, 2020 Abstract The characterization of runs of homozygosity (ROH), using high-density single nucleotide polymorphisms (SNPs) allows inferences to be made about the past demographic history of animal populations and the genomic ROH has become a common approach to characterize the inbreeding.
Grazyella M. Yoshida +4 more
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Runs of homozygosity: windows into population history and trait architecture [PDF]
Nature Reviews Genetics, 2018 Long runs of homozygosity (ROH) arise when identical haplotypes are inherited from each parent and thus a long tract of genotypes is homozygous. Cousin marriage or inbreeding gives rise to such autozygosity; however, genome-wide data reveal that ROH are universally common in human genomes even among outbred individuals.
Ceballos, Francisco C. +4 more
openaire +6 more sources
Vizualizacija "Runs of Homozygosity" DNA segmenata [PDF]
, 2018 "Runs of homozygosity" are segments or whole genomic regions where the identical haplotypes are inherited from each parent. Since their discovery because of the technological advances in late 90s, "Runs of homozygosity" shed some light on about individual genome origin, decoding the genetic base of monogenic and complex traits and diseases.
Hrženjak, Marko
openaire +2 more sources
Runs of Homozygosity in Modern Chicken Revealed by Sequence Data
G3: Genes, Genomes, Genetics, 2020 Runs of homozygosity (ROH) are chromosomal stretches that in a diploid genome appear in a homozygous state and display identical alleles at multiple contiguous loci.
Reza Talebi +3 more
doaj +3 more sources
Runs of Homozygosity and Inferences in Wild Populations. [PDF]
Mol EcolLong homozygous chromosome segments are known as runs of homozygosity (ROH); these reflect patterns of identity by descent and can be used to measure individual inbreeding, map recessive traits, and reconstruct demographic histories. Here we review some key considerations with ROH detection and the inferences pertaining to inbreeding and demographic ...
Shafer ABA, Kardos M.
europepmc +3 more sources
Runs of homozygosity in Worldwide cattle breeds [PDF]
, 2022 Data supporting the findings of the paper "Analysis of Runs of Homozygosity of cattle living in different climate zones " in Animal ...
Cesarani, A
core +3 more sources
Runs of homozygosity and analysis of inbreeding depression [PDF]
Journal of Animal Science, 2020 Abstract Pedigree information was traditionally used to assess inbreeding. The availability of high-density marker panels provides an alternative to assess inbreeding, particularly in the presence of incomplete and error-prone pedigrees.
Pattarapol Sumreddee +5 more
openaire +3 more sources
Ethnic Identity and Genome Wide Runs of Homozygosity [PDF]
Behavior Genetics, 2021 AbstractIt is long known that inbreeding increases the detrimental effects of recessive sequence variants in “Runs of Homozygosity” (ROHs). However, although the phenotypic association of ROH has been investigated for a variety of traits, the statistical power of the results often remains limited as a sufficiently high number of cases are available for
Fieder, Martin +4 more
openaire +7 more sources
The effects of runs-of-homozygosity on pig domestication and breeding. [PDF]
BMC GenomicsSince their domestication, recent inbreeding together with intensive artificial selection and population bottlenecks have allowed the prevalence of deleterious mutations and the increase of runs-of-homozygosity (ROH) in domestic pigs. This makes pigs a good model to understand the genetic underpinnings of inbreeding depression.Here we integrated a ...
Tao L +5 more
europepmc +4 more sources
Runs of homozygosity and inbreeding in thyroid cancer [PDF]
BMC Cancer, 2016 Genome-wide association studies (GWASs) have identified several single-nucleotide polymorphisms (SNPs) influencing the risk of thyroid cancer (TC). Most cancer predisposition genes identified through GWASs function in a co-dominant manner, and studies have not found evidence for recessively functioning disease loci in TC.
Thomsen H +13 more
openaire +3 more sources