Results 11 to 20 of about 167,442,745 (268)
Long runs of homozygosity are associated with Alzheimer’s disease [PDF]
Translational Psychiatry, 2021 Long runs of homozygosity (ROH) are contiguous stretches of homozygous genotypes, which are a footprint of inbreeding and recessive inheritance. The presence of recessive loci is suggested for Alzheimer’s disease (AD); however, their search has been ...
Sonia Moreno-Grau +45 more
doaj +16 more sources
Runs of Homozygosity Preliminary Investigation in Pig Breeds [PDF]
AnimalsRuns of homozygosity (ROH) are contiguous homozygous genomic segments that provide valuable insights into population history, selection pressures, and inbreeding levels. However, the global distribution of ROH and their implications for pig domestication
Yuqiang Liu +6 more
doaj +4 more sources
Analysis of Runs of Homozygosity in Aberdeen Angus Cattle [PDF]
AnimalsA large number of cattle breeds have marked phenotypic differences. They are valuable models for studying genome evolution. ROH analysis can facilitate the discovery of genomic regions that may explain phenotypic differences between breeds affecting ...
Vladimir Kolpakov +3 more
doaj +4 more sources
Runs of homozygosity do not influence survival to old age. [PDF]
PLoS ONE, 2011 Runs of homozygosity (ROH) are extended tracts of adjacent homozygous single nucleotide polymorphisms (SNPs) that are more common in unrelated individuals than previously thought. It has been proposed that estimating ROH on a genome-wide level, by making
Maris Kuningas +6 more
doaj +8 more sources
Runs of homozygosity and testicular cancer risk [PDF]
Andrology, 2022 Background Testicular germ cell tumour (TGCT) is highly heritable but > 50% of the genetic risk remains unexplained. Epidemiological observation of greater relative risk to brothers of men with TGCT compared to sons has long alluded to recessively acting
R. Eeles +19 more
core +11 more sources
Runs of Homozygosity in European Populations [PDF]
The American Journal of Human Genetics, 2008 Estimating individual genome-wide autozygosity is important both in the identification of recessive disease variants via homozygosity mapping and in the investigation of the effects of genome-wide homozygosity on traits of biomedical importance ...
Wright, Alan F +29 more
core +10 more sources
Runs of homozygosity implicate autozygosity as a schizophrenia risk factor. [PDF]
PLoS Genetics, 2012 Autozygosity occurs when two chromosomal segments that are identical from a common ancestor are inherited from each parent. This occurs at high rates in the offspring of mates who are closely related (inbreeding), but also occurs at lower levels among ...
Matthew C Keller +10 more
doaj +12 more sources
Genomic Inbreeding and Runs of Homozygosity Analysis of Cashmere Goat [PDF]
AnimalsCashmere goats are valuable genetic resources which are famous worldwide for their high-quality fiber. Runs of homozygosity (ROHs) have been identified as an efficient tool to assess inbreeding level and identify related genes under selection.
Qian Zhao +11 more
doaj +4 more sources
Genomic Diversity and Runs of Homozygosity in Bernese Mountain Dogs [PDF]
Genes, 2023 Bernese mountain dogs are a large dog breed formed in the early 1900s in Switzerland. While originally farm dogs that were used for pulling carts, guarding, and driving cattle, today they are considered multi-purpose companion and family dogs.
Anna Snell +24 more
core +5 more sources
Genomic prediction based on runs of homozygosity [PDF]
Genetics Selection Evolution, 2014 Background: Genomic prediction is based on the accurate estimation of the genomic relationships among and between training animals and selection candidates in order to obtain accurate estimates of the genomic estimated breeding values (GEBV).
Theo HE Meuwissen +14 more
core +6 more sources