Results 11 to 20 of about 7,051 (240)
Long runs of homozygosity are associated with Alzheimer’s disease [PDF]
Translational Psychiatry, 2021 Long runs of homozygosity (ROH) are contiguous stretches of homozygous genotypes, which are a footprint of inbreeding and recessive inheritance. The presence of recessive loci is suggested for Alzheimer’s disease (AD); however, their search has been ...
Sonia Moreno-Grau +45 more
doaj +13 more sources
Runs of homozygosity and population history in cattle [PDF]
BMC Genetics, 2012 Background Runs of homozygosity (ROH) are contiguous lengths of homozygous genotypes that are present in an individual due to parents transmitting identical haplotypes to their offspring.
Purfield Deirdre C +3 more
doaj +4 more sources
Genomic runs of homozygosity record population history and consanguinity.
PLoS ONE, 2010 The human genome is characterised by many runs of homozygous genotypes, where identical haplotypes were inherited from each parent. The length of each run is determined partly by the number of generations since the common ancestor: offspring of cousin ...
Mirna Kirin +5 more
doaj +4 more sources
Runs of homozygosity do not influence survival to old age. [PDF]
PLoS ONE, 2011 Runs of homozygosity (ROH) are extended tracts of adjacent homozygous single nucleotide polymorphisms (SNPs) that are more common in unrelated individuals than previously thought. It has been proposed that estimating ROH on a genome-wide level, by making
Maris Kuningas +6 more
doaj +6 more sources
Runs of Homozygosity in Modern Chicken Revealed by Sequence Data
G3: Genes, Genomes, Genetics, 2020 Runs of homozygosity (ROH) are chromosomal stretches that in a diploid genome appear in a homozygous state and display identical alleles at multiple contiguous loci.
Reza Talebi +3 more
doaj +3 more sources
Runs of homozygosity implicate autozygosity as a schizophrenia risk factor.
PLoS Genetics, 2012 Autozygosity occurs when two chromosomal segments that are identical from a common ancestor are inherited from each parent. This occurs at high rates in the offspring of mates who are closely related (inbreeding), but also occurs at lower levels among ...
Matthew C Keller +10 more
doaj +10 more sources
Runs of Homozygosity in European Populations [PDF]
The American Journal of Human Genetics, 2008 Estimating individual genome-wide autozygosity is important both in the identification of recessive disease variants via homozygosity mapping and in the investigation of the effects of genome-wide homozygosity on traits of biomedical importance. Approaches have tended to involve either single-point estimates or rather complex multipoint methods of ...
McQuillan, Ruth +20 more
+9 more sources
Runs of Homozygosity and Inferences in Wild Populations. [PDF]
Mol EcolLong homozygous chromosome segments are known as runs of homozygosity (ROH); these reflect patterns of identity by descent and can be used to measure individual inbreeding, map recessive traits, and reconstruct demographic histories. Here we review some key considerations with ROH detection and the inferences pertaining to inbreeding and demographic ...
Shafer ABA, Kardos M.
europepmc +3 more sources
Runs of homozygosity and analysis of inbreeding depression [PDF]
Journal of Animal Science, 2020 Abstract Pedigree information was traditionally used to assess inbreeding. The availability of high-density marker panels provides an alternative to assess inbreeding, particularly in the presence of incomplete and error-prone pedigrees.
Pattarapol Sumreddee +5 more
openaire +3 more sources
Ethnic Identity and Genome Wide Runs of Homozygosity [PDF]
Behavior Genetics, 2021 AbstractIt is long known that inbreeding increases the detrimental effects of recessive sequence variants in “Runs of Homozygosity” (ROHs). However, although the phenotypic association of ROH has been investigated for a variety of traits, the statistical power of the results often remains limited as a sufficiently high number of cases are available for
Fieder, Martin +4 more
openaire +7 more sources