Results 11 to 20 of about 8,739 (269)

Long runs of homozygosity are associated with Alzheimer’s disease [PDF]

Translational Psychiatry, 2021
Long runs of homozygosity (ROH) are contiguous stretches of homozygous genotypes, which are a footprint of inbreeding and recessive inheritance. The presence of recessive loci is suggested for Alzheimer’s disease (AD); however, their search has been ...
Sonia Moreno-Grau, Maria Victoria Fernández, Itziar de Rojas, Pablo Garcia-González, Isabel Hernández, Fabiana Farias, John P. Budde, Inés Quintela, Laura Madrid, Antonio González-Pérez, Laura Montrreal, Emilio Alarcón-Martín, Montserrat Alegret, Olalla Maroñas, Juan Antonio Pineda, Juan Macías, The GR@ACE study group, DEGESCO consortium, Marta Marquié, Sergi Valero, Alba Benaque, Jordi Clarimón, Maria Jesus Bullido, Guillermo García-Ribas, Pau Pástor, Pascual Sánchez-Juan, Victoria Álvarez, Gerard Piñol-Ripoll, Jose María García-Alberca, José Luis Royo, Emilio Franco-Macías, Pablo Mir, Miguel Calero, Miguel Medina, Alberto Rábano, Jesús Ávila, Carmen Antúnez, Luis Miguel Real, Adelina Orellana, Ángel Carracedo, María Eugenia Sáez, Lluís Tárraga, Mercè Boada, Carlos Cruchaga, Agustín Ruiz, for the Alzheimer’s Disease Neuroimaging Initiative   +45 more
doaj   +21 more sources

Runs of homozygosity do not influence survival to old age. [PDF]

PLoS ONE, 2011
Runs of homozygosity (ROH) are extended tracts of adjacent homozygous single nucleotide polymorphisms (SNPs) that are more common in unrelated individuals than previously thought. It has been proposed that estimating ROH on a genome-wide level, by making
Maris Kuningas, Ruth McQuillan, James F Wilson, Albert Hofman, Cornelia M van Duijn, André G Uitterlinden, Henning Tiemeier   +6 more
doaj   +9 more sources

Genomic runs of homozygosity record population history and consanguinity. [PDF]

PLoS ONE, 2010
The human genome is characterised by many runs of homozygous genotypes, where identical haplotypes were inherited from each parent. The length of each run is determined partly by the number of generations since the common ancestor: offspring of cousin ...
Mirna Kirin, Ruth McQuillan, Christopher S Franklin, Harry Campbell, Paul M McKeigue, James F Wilson   +5 more
doaj   +6 more sources

Runs of homozygosity implicate autozygosity as a schizophrenia risk factor. [PDF]

PLoS Genetics, 2012
Autozygosity occurs when two chromosomal segments that are identical from a common ancestor are inherited from each parent. This occurs at high rates in the offspring of mates who are closely related (inbreeding), but also occurs at lower levels among ...
Matthew C Keller, Matthew A Simonson, Stephan Ripke, Ben M Neale, Pablo V Gejman, Daniel P Howrigan, Sang Hong Lee, Todd Lencz, Douglas F Levinson, Patrick F Sullivan, Schizophrenia Psychiatric Genome-Wide Association Study Consortium   +10 more
doaj   +14 more sources

Runs of Homozygosity in European Populations [PDF]

The American Journal of Human Genetics, 2008
Estimating individual genome-wide autozygosity is important both in the identification of recessive disease variants via homozygosity mapping and in the investigation of the effects of genome-wide homozygosity on traits of biomedical importance. Approaches have tended to involve either single-point estimates or rather complex multipoint methods of ...
McQuillan, Ruth, Leutenegger, Anne-Louise, Abdel-Rahman, Rehab, Franklin, Christopher S, Pericic, Marijana, Barac-Lauc, Lovorka, Smolej-Narancic, Nina, Janicijevic, Branka, Polasek, Ozren, Tenesa, Albert, Macleod, Andrew K, Farrington, Susan M; id_orcid 0000-0001-5955-7389, Rudan, Pavao, Hayward, Caroline; id_orcid 0000-0002-9405-9550, Vitart, Veronique, Rudan, Igor, Wild, Sarah H; id_orcid 0000-0001-7824-2569, Dunlop, Malcolm G, Wright, Alan F, Campbell, Harry; id_orcid 0000-0002-6169-6262, Wilson, James F; id_orcid 0000-0001-5751-9178   +20 more
core   +11 more sources

Runs of homozygosity and testicular cancer risk [PDF]

Andrology, 2019
AbstractBackgroundTesticular germ cell tumour (TGCT) is highly heritable but > 50% of the genetic risk remains unexplained. Epidemiological observation of greater relative risk to brothers of men with TGCT compared to sons has long alluded to recessively acting TGCT genetic susceptibility factors, but to date none have been reported.
Loveday, C., Sud, A., Litchfield, K., Levy, M., Holroyd, A., Broderick, P., Kote-Jarai, Z., Dunning, A.M., Muir, K., Peto, J., Eeles, R., Easton, D.F., Dudakia, D., Orr, N., Pashayan, N., Rustin, Gordon, Srihari, Narayanan N., Cole, David, Askill, Colin, Bertelli, Gianfilippo, Barber, James, Gilby, Ed, White, Jeff, Baybrooke, Jeremy, Leahy, Michael, Welch, Richard, Chakraborti, Prabir, Joffe, Johnathan, Brown, Richard, Faust, Guy, Simmonds, Peter, Mazhar, Danish, Stockdale, Andrew, Hrounda, David, Humber, Caroline, Appel, Wiebke, Hong, Anne, Howard, Grahame, Douglas, Fiona, Bloomfield, David, Butt, Mohammad, Kelly, Kay, Mehra, Rakesh, Brown, Richard, Rogers, Paul, Chakraborti, Prabir, Hatton, Matthew, Hennig, Ivo, McAteer, John, Savage, Philip, Seckl, Michael, Gale, Joanna, Rustin, Gordon, Clark, Peter, Woby, Steve, Rathmell, Adrian, Lamont, Alan, Sarwar, Naveed, Stuart, Nick, Chowdhury, Simon, Beesley, Sharon, Winkler, Mathius, Hamid, Abdel, Pathak, Sanjeev, Madhavan, Krishnaswamy, Highley, Martin, Money-Kryle, Julian, Brock, Cathryn, Sreenivasan, Thiagarajan, Henderson, Brian E., Haiman, Christopher A., Schumacher, Fredrick R., Al Olama, Ali Amin, Benlloch, Sara, Berndt, Sonja I., Conti, David V., Wiklund, Fredrik, Chanock, Stephen, Gapster, Susan, Stevens, Victoria L., Tangen, Catherine M., Batra, Jyotsna, Clements, Judith, Gronberg, Henrik, Schleutker, Johanna, Albanes, Demetrius, Wolk, Alicja, West, Catharine, Mucci, Lorelei, Cancel-Tassin, Geraldine, Koutros, Stella, Sorensen, Karina Dalsgaard, Maehle, Lovise, Neal, David E., Hamdy, Freddie C., Donovan, Jenny L., Travis, Ruth C., Hamilton, Robert J., Ingles, Sue Ann, Rosenstein, Barry S., Lu, Yong-Jie, Giles, Graham G., Kibel, Adam S., Vega, Ana, Kogevinas, Manolis, Penney, Kathryn L., Park, Jong Y., Stanford, Janet L., Cybulski, Cezary, Nordestgaard, Borge G., Brenner, Hermann, Maier, Christiane, Kim, Jeri, John, Esther M., Teixeira, Manuel R., Neuhausen, Susan L., De Ruyck, Kim, Razack, Azad, Newcomb, Lisa F., Lessel, Davor, Kaneva, Radka, Usmani, Nawaid, Claessens, Frank, Townsend, Paul A., Dominguez, Manuela Gago, Roobol, Monique J., Menegaux, Florence, Khaw, Kay-Tee, Cannon-Albrigh, Lisa, Pandha, Hardev, Thibodeau, Stephen N., Reid, A., Huddart, R.A., Houlston, R.S., Turnbull, C.   +134 more
core   +13 more sources

Genomic Diversity and Runs of Homozygosity in Bernese Mountain Dogs [PDF]

Genes, 2023
Bernese mountain dogs are a large dog breed formed in the early 1900s in Switzerland. While originally farm dogs that were used for pulling carts, guarding, and driving cattle, today they are considered multi-purpose companion and family dogs. The breed is predisposed to several complex diseases, such as histiocytic sarcoma, degenerative myelopathy, or
Anna Letko, Benoît Hédan, Anna Snell, Alexander C. Harris, Vidhya Jagannathan, Göran Andersson, Bodil S. Holst, Elaine A. Ostrander, Pascale Quignon, Catherine André, Tosso Leeb   +10 more
openaire   +5 more sources

Genomic prediction based on runs of homozygosity [PDF]

Genetics Selection Evolution, 2014
Genomic prediction is based on the accurate estimation of the genomic relationships among and between training animals and selection candidates in order to obtain accurate estimates of the genomic estimated breeding values (GEBV). Various methods have been used to predict GEBV based on population-wide linkage disequilibrium relationships (G IBS ) or ...
Luan, Tu, Yu, Xijiang, Dolezal, Marlies, Bagnato, Alessandro, Meuwissen, Theo He   +4 more
openaire   +6 more sources

Estimation of inbreeding in Ethiopia goats using runs of homozygosity [PDF]

Acta Fytotechnica et Zootechnica, 2017
This study was carried out to estimate the inbreeding levels in Abergelle, Gumuz, Keffa and Woytoguji goats in Ethiopia from genomic information. A total of 161 animals (53 Abergelle, 39 Gumuz, 31 Keffa and 38 Woytoguji) were genotyped using the Illumina
Wilson Nandolo , Maria Wurzinger, Gábor Mészáros et al.   +2 more
doaj   +2 more sources

Runs of homozygosity and population history in cattle [PDF]

BMC Genetics, 2012
Background Runs of homozygosity (ROH) are contiguous lengths of homozygous genotypes that are present in an individual due to parents transmitting identical haplotypes to their offspring.
Purfield Deirdre C, Berry Donagh P, McParland Sinead, Bradley Daniel G   +3 more
doaj   +4 more sources