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Metal Ruthenium Complexes Treat Spinal Cord Injury By Alleviating Oxidative Stress Through Interaction With Antioxidant 1 Copper Chaperone Protein [PDF]

Advanced Science
Oxidative stress is a major factor affecting spinal cord injury (SCI) prognosis. A ruthenium metal complex can aid in treating SCI by scavenging reactive oxygen species via a protein‐regulated mechanism to alleviate oxidative stress.
Juanjuan Li, Cheng Peng, Caiqiang Huang, Li Wan, Ke Wang, Ping Wu, Tianjun Chen, Guodong Sun, Rui Guo, Hongsheng Lin, Zhisheng Ji   +10 more
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Bypassing the Resistance Mechanisms of the Tumor Ecosystem by Targeting the Endoplasmic Reticulum Stress Pathway Using Ruthenium- and Osmium-Based Organometallic Compounds: An Exciting Long-Term Collaboration with Dr. Michel Pfeffer

Molecules, 2021
Metal complexes have been used to treat cancer since the discovery of cisplatin and its interaction with DNA in the 1960’s. Facing the resistance mechanisms against platinum salts and their side effects, safer therapeutic approaches have been sought ...
Christian Gaiddon, Isabelle Gross, Xiangjun Meng, Marjorie Sidhoum, Georg Mellitzer, Benoit Romain, Jean-Batiste Delhorme, Aïna Venkatasamy, Alain C. Jung, Michel Pfeffer   +9 more
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Synthesis, spectral, dna binding and cleavage properties of ruthenium(II) Schiff base complexes containing PPh3/AsPh3 as co-ligands [PDF]

Journal of the Serbian Chemical Society, 2014
A dihydroxybenzaldehyde Schiff base ligands (L1-L3) and its ruthenium(II) complexes, have been synthesized and characterized on the basis of elemental analysis, 1H, 13C, 31P NMR, mass spectra, UV-vis and IR spectra.
Sathiyaraj Subbaiyan, Ayyannan Ganesan, Jayabalakrishnan Chinnasamy   +2 more
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Ruthenium(II) dimethyl sulphoxide based complexes: A potent inducer of apoptosis

Results in Chemistry, 2022
Ruthenium (Ru) Dimethylsulphoxide complexes have appeared as a prominent compound among the potential metal-based drug for the cure of cancer. Cancer is marked with the uncontrolled proliferative activity that can be treated with apoptosis inducers ...
Sunita Khatkar, Santosh Kumar Dubey, Priyanka Saraf, Jitender Kumar Bhardwaj, Satish Kumar, V. Kumar, Gaje Singh, Shayoraj   +7 more
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Biological Activities of Ruthenium NHC Complexes: An Update

Antibiotics, 2023
Ruthenium N-heterocyclic carbene (NHC) complexes have unique physico-chemical properties as catalysts and a huge potential in medicinal chemistry and pharmacology, exhibiting a variety of notable biological activities.
Alessia Catalano, Annaluisa Mariconda, Maria Stefania Sinicropi, Jessica Ceramella, Domenico Iacopetta, Carmela Saturnino, Pasquale Longo   +6 more
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Antioxidant Activity of Ruthenium Cyclopentadienyl Complexes Bearing Succinimidato and Phthalimidato Ligands

Molecules, 2022
In these studies, we investigated the antioxidant activity of three ruthenium cyclopentadienyl complexes bearing different imidato ligands: (η5-cyclopentadienyl)Ru(CO)2-N-methoxysuccinimidato (1), (η5-cyclopentadienyl)Ru(CO)2-N-ethoxysuccinimidato (2 ...
Michał Juszczak, Magdalena Kluska, Aneta Kosińska, Bogna Rudolf, Katarzyna Woźniak   +4 more
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Ru(II) complexes containing NOO donors of tridentate Schiff base ligands: Synthesis, characterization, crystal structure and catalytic activity in transfer hydrogenation of ketones

Chemistry of Inorganic Materials, 2023
A new series of pincer type ruthenium(II) Schiff base complexes namely [Ru(CO)(PPh3)2(L1‒6)] (1–6) (where, L1‒6 ​= ​NOO ‒ donors of tri-dentate ligands) have been synthesized from ruthenium precursor such as [RuHCl(CO)(PPh3)3] containing tri-dentate ...
Premkumar Muniyappan, Vijayan Paranthaman, Venkatachalam Galmari   +2 more
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Applications of Ruthenium Complex in Tumor Diagnosis and Therapy

Frontiers in Pharmacology, 2018
Ruthenium complexes are a new generation of metal antitumor drugs that are currently of great interest in multidisciplinary research. In this review article, we introduce the applications of ruthenium complexes in the diagnosis and therapy of tumors.
Ke Lin, Zi-Zhuo Zhao, Hua-Ben Bo, Xiao-Juan Hao, Jin-Quan Wang   +4 more
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The Influence of Some Axial Ligands on Ruthenium–Phthalocyanine Complexes: Chemical, Photochemical, and Photobiological Properties

Frontiers in Molecular Biosciences, 2021
This work presents a new procedure to synthesize ruthenium–phthalocyanine complexes and uses diverse spectroscopic techniques to characterize trans-[RuCl(Pc)DMSO] (I) (Pc = phthalocyanine) and trans-[Ru(Pc)(4-ampy)2] (II) (4-ampy = 4-aminopyridine).
Tássia Joi Martins, Tássia Joi Martins, Laisa Bonafim Negri, Laisa Bonafim Negri, Laisa Bonafim Negri, Laena Pernomian, Laena Pernomian, Kelson do Carmo Freitas Faial, Congcong Xue, Regina N. Akhimie, Michael R. Hamblin, Claudia Turro, Roberto S. da Silva, Roberto S. da Silva, Roberto S. da Silva, Roberto S. da Silva   +15 more
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3-Methylindole-Based Tripodal Tetraphosphine Ruthenium Complexes in N2 Coordination and Reduction and Formic Acid Dehydrogenation

Inorganics, 2017
The ruthenium(II) complexes RuCl2L1H, RuCl2L1CF3, RuCl2L1OMe and RuCl2L2H were synthesized from [Ru(η6-benzene)Cl(μ-Cl)]2 and the corresponding tripodal tris-3-methylindolephosphine-based ligands L1H, L1CF3, L1OMe, and L2H.
Fenna F. van de Watering, Nicol Heijtbrink, Jarl Ivar van der Vlugt, Wojciech I. Dzik, Bas de Bruin, Joost N. H. Reek   +5 more
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