Results 21 to 30 of about 40,348 (311)

Metal complexes as DNA intercalators [PDF]

, 2011
DNA has a strong affinity for many heterocyclic aromatic dyes, such as acridine and its derivatives. Lerman in 1961 first proposed intercalation as the source of this affinity, and this mode of DNA binding has since attracted considerable research ...
Peter J. Sadler, Hong-Ke Liu, Sadler, P. J., Liu, Hong-Ke   +3 more
core   +1 more source

Apoptotic Properties of Rutheinum Complexes on Different Type of Cancer Cell Lines

Proceedings, 2018
Among chemotherapeutic agents, cisplatin and the other platinum-based drugs have occupied for 35 years an enviable position. The limitations of platinum-based drugs, dose dependent side effects and development of drug resistance mechanisms, have boosted ...
Hafize Seda Vatansever, Hilal Kabadayı, Mehmet Korkmaz, Feyzan Özdal-Kurt, Serdar Batıkan Kavukcu, Hayati Türkmen   +5 more
doaj   +1 more source

Electrochemical Detection of Tadalafil at Glassy Carbon Electrodes Modified with Ruthenium(II) Complex

International Journal of Electrochemical Science, 2020
Ruthenium complexes are well known for their electrochemical activity, which could be attributed to the presence of stable ruthenium complexes with divalent ruthenium center, Ru2+.
Eyad S.M. Abu-Nameh, Naela Al Absi, Mohammad A. Al-Wahish, Hamdallah A. Hodali, Mohammad F. Khanfar   +4 more
doaj   +1 more source

Organometallic half-sandwich iridium anticancer complexes [PDF]

, 2011
The low-spin 5d6 IrIII organometallic half-sandwich complexes [(η5-Cpx)Ir(XY)Cl]0/+, Cpx = Cp*, tetramethyl(phenyl)cyclopentadienyl (Cpxph), or tetramethyl(biphenyl)cyclopentadienyl (Cpxbiph), XY = 1,10-phenanthroline (4−6), 2,2′-bipyridine (7−9 ...
Liu, Zhe, Bruijnincx, P.C.A., Brabec, V., Clarkson, Guy J., Sally A. Fletcher, Liu, Z., Vrana, O., Guy J. Clarkson, Fletcher, Sally A., Vrana, Oldrich, Salassa, Luca, Brabec, V. (Viktor), Fletcher, S.A., Kisova, A., Peter J. Sadler, Clarkson, G.J., Pizarro, A.M., Viktor Brabec, Bruijnincx, Pieter C. A., Oldrich Vrana, Sadler, P. J., Pieter C. A. Bruijnincx, Zhe Liu, Salassa, L., Luca Salassa, Habtemariam, A., Inorganic Chemistry and Catalysis, Sub Inorganic Chemistry and Catalysis, Pizarro, Ana M., Sadler, Peter J., Ana M. Pizarro, Kisova, Anna, Habtemariam, Abraha, Abraha Habtemariam, Anna Kisova   +34 more
core   +1 more source

Antitumor Activity of Ruthenium(II) Terpyridine Complexes towards Colon Cancer Cells In Vitro and In Vivo

Molecules, 2020
Ruthenium complexes have attracted considerable interest as potential antitumor agents. Therefore, antitumor activity and systemic toxicity of ruthenium(II) terpyridine complexes were evaluated in heterotopic mouse colon carcinoma.
Maja Savic, Aleksandar Arsenijevic, Jelena Milovanovic, Bojana Stojanovic, Vesna Stankovic, Ana Rilak Simovic, Dejan Lazic, Nebojsa Arsenijevic, Marija Milovanovic   +8 more
doaj   +1 more source

Bipyridine Ruthenium(II) Complexes with Halogen-Substituted Salicylates: Synthesis, Crystal Structure, and Biological Activity

Molecules, 2023
Ruthenium complexes currently represent a perspective subject of investigation in terms of potential anticancer therapeutics. Eight novel octahedral ruthenium(II) complexes are the subject of this article.
Martin Schoeller, Milan Piroš, Miroslava Litecká, Katarína Koňariková, Flóra Jozefíková, Alexandra Šagátová, Eva Zahradníková, Jindra Valentová, Ján Moncol   +8 more
doaj   +1 more source

Functionalization of osmium arene anticancer complexes with (poly)arginine : effect on cellular uptake, internalization, and cytotoxicity [PDF]

, 2011
Attaching peptides to metallodrugs may result in improved biological properties of the complexes. The potential use of cell penetrating peptides (CPPs) as cell delivery vectors is attractive, since directed cell uptake of (metallo)drugs remains a major ...
Rijt, Sabine H. van, Peter J. Sadler, Sadler, P. J., Hana Kostrhunova, Viktor Brabec, Brabec, V. (Viktor), Sabine H. van Rijt, Kostrhunova, Hana   +7 more
core   +1 more source

Synthesis, Characterization, and Electrochemical Activities of Ruthenium(II) Bipyridyl-Dithiocarbamate Complexes

International Journal of Photoenergy, 2022
Five heteroleptic ruthenium(II) polypyridyl complexes [Ru(FL1)(dcbpy)(NCS)] (1), [Ru(FL2)(dcbpy)(NCS)] (2), [Ru(FL3)(dcbpy)(NCS)] (3), [Ru(FL1)(dcbpy)(NCS)] (4), and [Ru(FL5)(dcbpy)(NCS)] (5) (where FL1 = aniline dithiocarbamate, FL2 = p-anisidine ...
Zintle Fudo, Peter A. Ajibade, Ayodele T. Odularu   +2 more
doaj   +1 more source

Novel ruthenium(ii) N-heterocyclic carbene complexes: Synthesis, characterization, and evaluation of their biological activities

Main Group Metal Chemistry, 2023
A series of ruthenium(ii) complexes with N-heterocyclic carbene (NHC) ligands of the general type (arene)(NHC)Ru(ii)X2 (where X = halide) (3a–3d) were synthesized and characterized in order to compare their antibacterial activities with benzimidazolium ...
Jawhari Ahmed Hussain, Amri Nasser, Mukhrish Yousef E., Gatri Rafik, Özdemir Ismail, Gürbüz Nevin, Mansour Lamjed, Koko Waleed S., Hamdi Naceur   +8 more
doaj   +1 more source

Somatostatin subtype-2 receptor-targeted metal-based anticancer complexes [PDF]

, 2012
Conjugates of a dicarba analogue of octreotide, a potent somatostatin agonist whose receptors are overexpressed on tumor cells, with [PtCl 2(dap)] (dap = 1-(carboxylic acid)-1,2-diaminoethane) (3), [(η 6-bip)Os(4-CO 2-pico)Cl] (bip = biphenyl, pico ...
González, Carlos A., Moreno Martínez, Virtudes, Carrion-Salip, Dolors, González-Cantó, A., Massaguer, A., Sadler, Peter, Llorens Duran, Rafael de, Massaguer i Vall-llovera, Anna, González Ibañez, Carlos, Massaguer, Anna, de Llorens, Rafael, Carrion-Salip, D, González, Carlos, Gómez-Pinto, Irene, Sadler, P. J., Moreno, Virtudes, Barragán, F., Barragán, Flavia, Sadler, P.J., Llorens, Rafael de, Marchán Sancho, Vicente, Sadler, Peter J., Carrion Salip, Dolors, Marchán, Vicente, González-Cantó, Alejandro   +24 more
core   +1 more source