Results 11 to 20 of about 982,093 (257)
Unusual DNA binding modes for metal anticancer complexes [PDF]
, 2009 DNA is believed to be the primary target for many metal-based drugs. For example, platinum-based anticancer drugs can form specific lesions on DNA that induce apoptosis.
Pizarro, Ana M., Sadler, P. J.
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CHIMIA, 2017 Ruthenium complexes, in particular cyclopentadienyl ruthenium (??) derivatives, catalyze a vast number of transformations in the field of homogenous catalysis.
David Kossler, Nicolai Cramer
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Ruthenium(II)–Cyclopentadienyl-Derived Complexes as New Emerging Anti-Colorectal Cancer Drugs
Pharmaceutics, 2022 Colorectal cancer (CRC) is one of the most common malignancies and one of the leading causes of cancer-related death worldwide, urging the need for new and more efficient therapeutic approaches. Ruthenium complexes have emerged as attractive alternatives
Catarina Teixeira-Guedes +4 more
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Ruthenium porphyrin-ß-cyclodextrin complexes as supramolecular enzyme models for regioselective cleavage of carotenoids [PDF]
, 2006 All naturally occurring vitamin A derives from enzymatic oxidative cleavage of β,β-carotene or other carotenoids with pro-vitamin A activity. Two metabolic pathways of β,β-carotene to retinal (vitamin A aldehyde) have been proposed: the central cleavage ...
Wang, Hao
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The contrasting activity of iodido versus chlorido ruthenium and osmium arene azo- and imino-pyridine anticancer complexes : control of cell selectivity, cross-resistance, p53 dependence, and apoptosis pathway [PDF]
, 2013 Organometallic half-sandwich complexes [M(p-cymene)(azo/imino-pyridine)X]+ where M = RuII or OsII and X ═ Cl or I, exhibit potent antiproliferative activity toward a range of cancer cells.
Sadler, P. J. +2 more
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Rationally Designed Ruthenium Complexes for Breast Cancer Therapy
Molecules, 2020 Since the discovery of the anticancer potential of ruthenium-based complexes, several species were reported as promising candidates for the treatment of breast cancer, which accounts for the greatest number of new cases in women every year worldwide ...
Golara Golbaghi, Annie Castonguay
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Apoptotic Properties of Rutheinum Complexes on Different Type of Cancer Cell Lines
Proceedings, 2018 Among chemotherapeutic agents, cisplatin and the other platinum-based drugs have occupied for 35 years an enviable position. The limitations of platinum-based drugs, dose dependent side effects and development of drug resistance mechanisms, have boosted ...
Hafize Seda Vatansever +5 more
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International Journal of Electrochemical Science, 2020 Ruthenium complexes are well known for their electrochemical activity, which could be attributed to the presence of stable ruthenium complexes with divalent ruthenium center, Ru2+.
Eyad S.M. Abu-Nameh +4 more
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Metal complexes as DNA intercalators [PDF]
, 2011 DNA has a strong affinity for many heterocyclic aromatic dyes, such as acridine and its derivatives. Lerman in 1961 first proposed intercalation as the source of this affinity, and this mode of DNA binding has since attracted considerable research ...
Peter J. Sadler +3 more
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Molecules, 2020 Ruthenium complexes have attracted considerable interest as potential antitumor agents. Therefore, antitumor activity and systemic toxicity of ruthenium(II) terpyridine complexes were evaluated in heterotopic mouse colon carcinoma.
Maja Savic +8 more
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