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RWD-Cockpit: Application for Quality Assessment of Real-world Data
JMIR Formative Research, 2022 BackgroundDigital technologies are transforming the health care system. A large part of information is generated as real-world data (RWD).
Lmar Marie Babrak +13 more
doaj +5 more sources
RWD-derived response in multiple myeloma
PLOS ONE, 2023 Real-world data (RWD) are important for understanding the treatment course and response patterns of patients with multiple myeloma. This exploratory pilot study establishes a way to reliably assess response from incomplete laboratory measurements captured in RWD. A rule-based algorithm, adapted from International Myeloma Working Group response criteria,
Tao Xu +10 more
openaire +4 more sources
RWD Domain as an E2 (Ubc9)-Interaction Module [PDF]
Journal of Biological Chemistry, 2015 An RWD domain is a well conserved domain found through bioinformatic analysis of the human proteome sequence; however, its function has been unknown. Ubiquitin-like modifications require the catalysis of three enzymes generally known as E1, E2, and E3.
Nigus Ambaye, Weidong Hu, Yi-Jia Li
exaly +3 more sources
Solution structure of the RWD domain of the mouse GCN2 protein [PDF]
Protein Science, 2004 AbstractGCN2 is the α‐subunit of the only translation initiation factor (eIF2α) kinase that appears in all eukaryotes. Its function requires an interaction with GCN1 via the domain at its N‐terminus, which is termed the RWD domain after three major RWD‐containing proteins: RING finger‐containing proteins, WD‐repeat‐containing proteins, and yeast DEAD ...
Piero Carninci +2 more
exaly +3 more sources
Assessing real-world evidence utilization in oncology health technology assessments: insights from external control-arm studies [PDF]
Oncology ReviewsBackgroundWhile health technology assessment (HTA) acceptance of contextual real-world data (RWD) studies describing burden of disease, disease natural history, or treatment pathways is relatively common, HTA practices for RWD studies addressing real ...
Gleicy Macedo Hair +9 more
doaj +2 more sources
A Comprehensive Mapping of Real-World Studies and Data Sources for Oncology in China: Insights into Landscape, Challenges, and Future Direction [PDF]
Oncology and TherapyIntroduction Cancer remains a major public health concern in China, with approximately 2.57 million cancer-related deaths reported in 2022. Real-world studies (RWS), which leverage high-quality real-world data (RWD), can generate robust real-world ...
Yaqi Jia +6 more
doaj +2 more sources
The power, potential of real-world data in randomized controlled trials: proceedings from a multistakeholder think tank [PDF]
TrialsRandomized controlled trials (RCTs) remain the gold standard for evaluating medical interventions, but they often face challenges related to patient recruitment, cost, and efficiency.
Nina Nouhravesh +12 more
doaj +2 more sources
PLoS ONE, 2022 BackgroundWe investigated the impact of the soluble fms-like tyrosine kinase 1 (sFlt-1)/placental growth factor (PlGF) ratio to predict short-term risk of preeclampsia on clinical utility and healthcare resource utilisation using real-world data (RWD ...
Anne Dathan-Stumpf +4 more
doaj +2 more sources
Digital Biomarkers, 2021 Background: The life science industry has a strong interest in real-world data (RWD), a term that is currently being used in many ways and with varying definitions depending on the source.
Frank Grimberg +5 more
doaj +1 more source
Frontiers in Medicine, 2022 Recently, there has been increased consideration of real-world data (RWD) and real-world evidence (RWE) in regulatory and health technology assessment (HTA) decision-making.
Ashley Jaksa +7 more
doaj +1 more source