Results 111 to 120 of about 27,021 (267)

Ultrasound Activated Piezoelectric Dural Patches to Drive Endogenous Neural Stem Cell–Mediated Repair Traumatic Brain Injury

Advanced Science, EarlyView.
This study presents a wireless, non‐invasive strategy for neural repair by developing a biodegradable piezoelectric dural patch that, under transcranial ultrasound, generates localized electrical fields to drive endogenous neural stem cells toward neuronal differentiation and functional integration.
Pengbo Zhou, Qingyuan Wu, Yang Wu, Runzhe Huang, Wei Li, Hanjie Niu, Hongtao Sun, Huiyu Liu   +7 more
wiley   +1 more source

Establishment and multifaceted characterization of a graded spinal cord injury model based on graduated impact depth

Animal Models and Experimental Medicine, EarlyView.
We established a graded spinal cord injury (SCI) model based on graduated impact depth, which was subsequently characterized across multiple dimensions, including locomotor function, imaging, histology, and transcriptomic profiles. We further identified transcriptomic changes in graded SCI at different time points postinjury and investigated the ...
Gang Zhou, Yue Hu, Zhimin Li, Shiyuan Han, Yuejia Li, Yongning Li, Jun Gao   +6 more
wiley   +1 more source

Study on Bottom Hole Assembly and Drilling Parameter Optimization for Reaming While Drilling

Shiyou jixie, 2021
Domestic studies on bottom hole assembly(BHA)and drilling parameter optimization for reaming while drilling(RWD)are lack of the calculation model which considers three influence factors(i.e., geometric configuration of pilot bit and reamer, formation ...
Zhang Jiawei, Ji Guodong, Guo Weihong, Wang Haigei, Cui Meng, Hui Cheng   +5 more
doaj  

On the Molecular Diffusion Dynamics Between Subcutaneous Tissue and Microneedles for Wearable Continuous Glucose Monitoring

Advanced NanoBiomed Research, EarlyView.
In this study, we investigate the dynamics of glucose diffusion between subcutaneous tissue and hydrogel‐filled microneedles. Specifically, we examine how hydrogel thickness, microneedle size, and glucose concentration influence diffusion. This study provides an experimental reference to the wearable biosensor community researching microneedle‐based ...
Wensheng Lin, Binbin Cui, Xuecheng He, Suo Tu, Shilei Dai, Xinran Zhang, Ivo Pang, Xiaonan Chen, Jixiang Zhu, Shiming Zhang   +9 more
wiley   +1 more source

RWD insights into disease progression

Alzheimer's & Dementia
AbstractBackgroundThe new anti‐Aβ antibody drugs aducanumab and lecanemab (approved in the US, not yet in Europe) must be followed up closely and regularly long‐term. Previous knowledge on progression of AD in routine clinical settings longterm is crucial when introducing new dementia medications.
openaire   +1 more source

Beyond the label: Rethinking off‐label drug use in paediatrics. Towards a scientifically grounded and safer future for paediatric pharmacotherapy

British Journal of Clinical Pharmacology, EarlyView.
Abstract Despite regulatory progress being made in the past two decades, off‐label drug use in paediatrics remains pervasive, with prevalence estimated between 3% and 97% of prescriptions across different clinical settings. Off‐label use—defined as prescribing outside the conditions described in the Summary of Product Characteristics (SmPC)—is often ...
Tjitske M. van der Zanden, Miriam G. Mooij, Matthijs de Hoog, Saskia N. de Wildt   +3 more
wiley   +1 more source

Recommendations for developing drug use definitions with an emphasis on real-world data sources

Реальная клиническая практика: данные и доказательства
There is currently no established framework for conceptualizing or implementing drug use. These recommendations provide a framework that outlines considerations to be considered when developing definitions of drug use in real-world clinical practice. The
A. S. Motrinchuk, M. V. Pchelintsev
doaj   +1 more source

Reading and writing difficulties in adolescence and later risk of welfare dependence. A ten year follow-up, the HUNT Study, Norway

BMC Public Health, 2011
Background Welfare dependence and low work participation among young people have raised concern in many European countries. Reading and writing difficulties (RWD) might make young people vulnerable to work integration problems and welfare dependence ...
Holmen Turid L, Westin Steinar, Bjørngaard Johan H, Pape Kristine, Krokstad Steinar   +4 more
doaj   +1 more source

Suzaku Observation of the Intermediate Polar V1223 Sagittarii

, 2011
We report on the Suzaku observation of the intermediate polar V1223 Sagittarii. Using a multi-temperature plasma emission model with its reflection from a cold matter, we obtained the shock temperature to be 37.9^{+5.1}_{-4.6} keV.
Bamba, Aya, Hayashi, Takayuki, Ishida, Manabu, Shionome, Takeshi, Terada, Yukikatsu   +4 more
core   +1 more source

Through the lens of marketing authorization holders: experience in use of real‐world data and real‐world evidence in drug development and regulatory submissions in EU

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim The aim of this study was to assess the general and product‐specific experiences of MAHs use of RWD/RWE in medicines development and in their regulatory submissions, and to explore organizational aspects of MAHs related to RWD/RWE. Methods An electronic survey was conducted, and information collected directly from MAHs.
Sini M. Eskola, Aleksandar Gigov, Hubertus G. M. Leufkens, Andrew Bate, Marie Louise De Bruin, Helga Gardarsdottir   +5 more
wiley   +1 more source