Results 121 to 130 of about 8,310 (238)

Recommendations for developing drug use definitions with an emphasis on real-world data sources

Реальная клиническая практика: данные и доказательства
There is currently no established framework for conceptualizing or implementing drug use. These recommendations provide a framework that outlines considerations to be considered when developing definitions of drug use in real-world clinical practice. The
A. S. Motrinchuk, M. V. Pchelintsev
doaj   +1 more source

Real‐World, Prospective, Multicenter Outcomes to Brodalumab Treatment in Patients With Moderate‐to‐Severe Psoriasis in Greece (The RESOLVE Study)

JEADV Clinical Practice, Volume 5, Issue 2, Page 458-469, June 2026.
RESOLVE was a prospective, real‐world study in patients with moderate‐to‐severe psoriasis treated with brodalumab. At Week 12, 76.4% achieved PASI ≤ 3, 53.5% PASI100, and 71.5%/54.2% achieved sPGA0/1 and sPGA 0, respectively. At Week 52, 96.1% achieved sPGA success (clear/almost clear). Furthermore, at Week 52, mean DLQI scores decreased by 12.6 ± 6.2,
Electra Nicolaidou, Pantelis Panagakis, Dimitrios Xekardakis, Natalia Rompoti, Marina Papoutsaki, Ioanna Lefaki, Kanella Kalapothakou, Despina Exadactylou, Athanasios Chaniotis, Vasiliki Chasapi, Alexander Stratigos   +10 more
wiley   +1 more source

Mental Health Among Caregivers of Children With Atopic Dermatitis: A Systematic Review With Meta‐Analysis

JEADV Clinical Practice, Volume 5, Issue 2, Page 425-432, June 2026.
This systematic review and meta‐analysis aimed to examine the association between child atopic dermatitis and caregiver mental health. Fifteen observational studies were identified through PubMed, EMBASE, and Web of Science, excluding non‐English publications, clinical trials, and case reports.
Hannah Kang, Joshua Xian, Emma Doan, Richard Kim, Josephine Tan, Morgan Ye, Katrina Abuabara   +6 more
wiley   +1 more source

Transportability Analyses in Comparative Effectiveness Research: A Conceptual Framework and Methodological Principles Endorsed by the International Society for Pharmacoepidemiology

Pharmacoepidemiology and Drug Safety, Volume 35, Issue 6, June 2026.
ABSTRACT The Problem Transportability considerations are increasingly important to answer research questions in comparative effectiveness research (CER) to support the transfer of evidence on medicinal products across countries or settings. As drug development costs rise and healthcare systems and professionals face economic and resource pressures ...
Blythe Adamson, Wei Liu, Stephen Duffield, Anouk Déruaz‐Luyet, Dimitri Bennett, Montse Soriano Gabarró, Mehmet Burcu, Daniela Claudia Moga, Sarah Welby, Tianze Jiao, Xuerong Wen, Grammati Sarri   +11 more
wiley   +1 more source

Age diversity - promoting equal opportunities in RWE

, 2012
The topic of the thesis entitled "Age diversity - promoting equal opportunities in RWE" is an analysis of diversity management tools specific to the company from 2011 to 2012, defining age management and proposing an action plan of age diversity in the ...
Procházková, Petra
core  

Methods Applied to Assess Real‐World Effectiveness of Drugs: A Scoping Review

Pharmacology Research &Perspectives, Volume 14, Issue 3, June 2026.
ABSTRACT Drug effectiveness evaluations are needed to bridge the gap between premarketing trials and clinical practice, but the specific methods used in such evaluations remain unclear. Therefore, this review aimed to identify pharmacoepidemiological effectiveness studies based on real‐world data (RWD) and categorize them based on the methods applied ...
Benedikte Irene von Osmanski, Janne Petersen, Charlotte Thor Petersen, Andreas Høiberg Bentsen, Espen Jimenez‐Solem, Mikkel Zöllner Ankarfeldt   +5 more
wiley   +1 more source

Determining the Character of Subglacial Sediments in the Ice‐Bedrock Interface Zone of Antarctica Using Horizontal‐to‐Vertical Spectral Ratios (HVSRs) of Seismic Ambient Noise

Journal of Geophysical Research: Solid Earth, Volume 131, Issue 6, June 2026.
Abstract Interactions between the Antarctic Ice Sheet and the underlying solid Earth occur within the ice‐bedrock interface zone (IBIZ), containing structures of sediments and rocks that strongly influence ice sheet dynamics. Existing insights into the Antarctic IBIZ come primarily from interpretations of airborne geophysical data and active seismic ...
I. D. Kelly, A. M. Reading, T. Stål, B. Kulessa, A. García‐Jerez, J. Piña‐Flores, E. Paolucci, A. Tanzini, R. J. Turner, J. C. Magyar, A. P. Bassom   +10 more
wiley   +1 more source

Use of Healthcare Claims Data to Generate Real-World Evidence on Patients With Drug-Resistant Epilepsy: Practical Considerations for Research

Journal of Health Economics and Outcomes Research
# Objectives Regulatory bodies, health technology assessment agencies, payers, physicians, and other decision-makers increasingly recognize the importance of real-world evidence (RWE) to provide important and relevant insights on treatment patterns ...
Nicole Stamas, Tom Vincent, Kathryn Evans, Qian Li, Vanessa Danielson, Reginald Lassagne, Ariel Berger   +6 more
doaj   +1 more source

Increased Risk for Liver Disease in Patients With Chronic Hepatitis B Virus Infection and Low‐Level Viraemia

Alimentary Pharmacology &Therapeutics, Volume 63, Issue 12, Page 1626-1634, June 2026.
We used an administrative claims dataset to evaluate the relationship between hepatitis B virus (HBV) low‐level viraemia and subsequent liver‐related outcomes in patients with chronic HBV. We found that individuals with HBV low‐level viraemia have an increased risk for liver‐related events (i.e., cirrhosis, decompensation, and hepatocellular carcinoma)
Paul Y. Kwo, Laura E. Telep, Lai San Hong, Ching Yi Chuo, Betty Chiang, Sarjita D. Naik, Catherine T. Frenette, Amanda W. Singer, Anand P. Chokkalingam, Robert J. Wong, Leland J. Yee, Camilla S. Graham   +11 more
wiley   +1 more source

From Precision to Personalized: Catalyzing AI‐Enabled Innovation in Drug Development

Clinical and Translational Science, Volume 19, Issue 6, June 2026.
ABSTRACT In 2015, President Obama announced the Precision Medicine Initiative in his nationally televised State of the Union address. The vision was bold: to enable a new era of medicine through research, technology, and policies that empower patients, researchers, and providers to work together toward the development of individualized care.
Adarsh Subbaswamy, Allison Dunn, Brooke Langevin, Sooyoung Lee, Mathangi Gopalakrishnan, Jogarao V. S. Gobburu   +5 more
wiley   +1 more source