Results 131 to 140 of about 31,472 (217)

CaV1.2 dynamics in native male arterial myocytes

The Journal of Physiology, Volume 604, Issue 15, Page 6302-6323, 1 August 2026.
Abstract figure legend Proposed model of microtubule‐dependent CaV1.2 reorganization in vascular disease. Schematic illustration of microtubule‐mediated delivery and stabilization of CaV1.2 channels into enlarged plasma membrane clusters in response to Ang II or hyperglycaemia, promoting cooperative gating and enhanced Ca2+ influx. Abstract L‐type CaV1.
Miguel Martin‐Aragon Baudel, Hannah Voorhees, Arsalan U. Syed, Maryann K. Ferrara, Mary Horne, Johannes W. Hell, Luis F. Santana, Rose E. Dixon, Madeline Nieves‐Cintron, Manuel F. Navedo   +9 more
wiley   +1 more source

Ryanodine receptor 2 mutations in catecholaminergic polymorphic ventricular tachycardia: From molecular mechanisms to precision medicine. [PDF]

World J Cardiol
Sharma V.
europepmc   +1 more source

Pharmacology, Medicinal Chemistry, and Therapeutic Potential of Imidazoline Receptor Ligands

ChemMedChem, Volume 21, Issue 13, 14 July 2026.
Building on the excellent review article by Dardonville and Rozas (2004), this paper summarizes the most representative ligands of imidazoline receptors (IR; I1, I2, and I3) and updates their pharmacological profiles. Although not exhaustive, it provides a solid starting point for understanding the significance of I2 IRs as promising therapeutic ...
Maria‐Eleni Kouridaki, Mercè Pallàs, Carmen Escolano   +2 more
wiley   +1 more source

Large-scale high-throughput screen for cardiac ryanodine receptor targeted therapeutics. [PDF]

J Biol Chem
Nikolaienko R, Bovo E, Solberg JC, Brinkmann M, Treinen LM, Thompson AR, Berg K, Thomas DD, Thomas JJ, Bers DM, Aldrich CC, Zima AV, Cornea RL, Rebbeck RT.   +13 more
europepmc   +1 more source

MINFLUX microscopy resolves subunits of the cardiac ryanodine receptor and its 3D orientation in cells. [PDF]

Nat Commun
Clowsley AH, Meletiou A, Janicek R, Bokhobza AFE, Lučinskaitė E, Bleuer G, Jansen I, Jones PP, Louch WE, Soeller C.   +9 more
europepmc   +1 more source

Crystal structures of Ryanodine Receptor reveal dantrolene and azumolene interactions guiding inhibitor development. [PDF]

Nat Commun
Hadiatullah H, Lin L, Wang Z, Sundarraj R, Wang Q, Lai X, Kurebayashi N, Kobayashi T, Yamazawa T, Chen YS, Wang W, Zhao H, Yin Y, Murayama T, Van Petegem F, Yuchi Z.   +15 more
europepmc   +1 more source

Allosteric modulation of ryanodine receptor RyR1 by nucleotide derivatives. [PDF]

Structure, 2023
Cholak S, Saville JW, Zhu X, Berezuk AM, Tuttle KS, Haji-Ghassemi O, Alvarado FJ, Van Petegem F, Subramaniam S.   +8 more
europepmc   +1 more source

Statins, skeletal muscle, and ryanodine receptor activation: resolving a 30-year mystery behind statin myotoxicity. [PDF]

Cardiovasc Diabetol Endocrinol Rep
Santulli G.
europepmc   +1 more source

<i>Drosophila</i> ryanodine receptor gene triggers functional and developmental muscle properties and could be used to assess the impact of human <i>RYR1</i> mutations. [PDF]

Elife
Zmojdzian M, Jagla T, Cherik F, Dubinska-Magiera M, Migocka-Patrzałek M, Daczewska M, Rendu J, Jagla K, Sarret C.   +8 more
europepmc   +1 more source

Ryanodine receptor 2-mediated calcium leak is associated with increased glyoxalase I in the aging brain. [PDF]

JCI Insight
Woo E, Datta D, Bathla S, Beatty H, Caglayan P, Albizu AK, Lam TT, Kanyo J, Joyce MK, Leslie S, Uchendu S, DeLong J, Guan QS, Li J, Abramson E, Herman AL, Cooper D, Licznerski P, Horvath TL, Jonas EA, Nairn AC, Arnsten AF, Sansing LH.   +22 more
europepmc   +1 more source