Results 111 to 120 of about 31,472 (217)

Sedentary ageing remodels the structure–function relationships that underlie calcium signalling at super‐resolution scales in the heart

The Journal of Physiology, EarlyView.
Abstract figure legend Illustration of calcium spark function and ryanodine receptor (RyR) structure within a sedentary model of ageing. Upon sympathetic stimulation from 1 µM isoprenaline a linear response to calcium spark morphology occurred, accompanied by a biphasic progression of RyR remodelling across age.
Miriam E. Hurley, David Conesa, Alan P. Benson, Michael A. Colman   +3 more
wiley   +1 more source

Old dog, new trick: Charybdotoxin as a novel ryanodine receptor blocker

The Journal of Physiology, EarlyView.
Abstract figure legend The peptide toxin charybdotoxin (ChTx) from the scorpion Leiurus quinquestriatus was tested on single‐channel currents of the ryanodine receptor incorporated into planar lipid bilayers. The structure–function relationship of ChTx was investigated using toxin variants generated by isosteric substitutions of the basic amino acids ...
Zsuzsanna Édua Magyar, Judit Hevesi, Frigyes Mészáros, Zsolt Bozsó, János Szolomájer, Gábor Tóth, György Panyi, Péter Enyedi, Zoltán Varga, Zoltán Pethő, János Almássy   +10 more
wiley   +1 more source

Testicular SIRT1 Loss Reveals an Aging‐Like Proteomic Landscape and Precipitates Reproductive Deterioration

Andrology, Volume 14, Issue 6, Page 1579-1589, September 2026.
ABSTRACT Background Advanced paternal age is associated with reduced male fertility and testicular dysfunction. Among the molecular regulators involved in aging, SIRT1, a NAD+‐dependent deacetylase, plays a pivotal role in maintaining oxidative balance and cellular homeostasis.
María Iniesta‐Cuerda, Jiřina Havránková, Hedvika Řimnáčová, Jiří Moravec, František Liška, Martin Knytl, Milena Králíčková, Jan Nevoral   +7 more
wiley   +1 more source

ADAMTS4 mediates LPS‐induced cardiac injury and myocardial fibrosis through proteolytic cleavage of TSP1

Clinical and Translational Medicine, Volume 16, Issue 8, August 2026.
• ADAMTS4 is induced primarily in cardiac fibroblasts during sepsis. • ADAMTS4 cleaves TSP1 at the 236–246 aa functional region. • TSP1 cleavage activates TGF‐β/Smad and NF‐κB signalling in fibroblasts. • Targeting ADAMTS4 reduces fibroblast activation and cardiac fibrosis.
Zhe‐Wei Zhang, Shi‐Yan Wan, Wen Li, Xiao Lu, Rong Chen, Xin Xing, Wei Lai, Shu‐Yang Sheng, M. M. Mosebetsi, Qing‐Tao Meng, Zi‐Long Lu, Di Fan, Wan‐Li Jiang   +12 more
wiley   +1 more source

Polarized Light Microscopy for Quantitative Assessment of Sarcomere‐Scale Structural Order in Cardiac Tissue

Journal of Biophotonics, Volume 19, Issue 8, August 2026.
Impact of cardiac and respiratory arrest on cardiac muscle tissue. Wistar rats were injected (on the left) either with cisatracurium to induce a respiratory arrest or lidocaine to induce a cardiac arrest (in the middle). Further, the pathophysiological changes developed and were assessed with linear polarization microscopy at 600–3000 nm wavelength ...
Gennadii Piavchenko, Artem Venediktov, Zoya Shamitko, Karina Urazova, Mariia Obelchakova, Evelina Khabarova, Anton Ershov, Natalia Kartashkina, Viktoria Grikh, Valerii Smirnov, Galina Ramenskaya, Alexander Yatskovskiy, Igor Meglinski   +12 more
wiley   +1 more source

Divergent AKT Signalling Mechanisms Regulate GLUT4 Translocation and Glucose Uptake in Skeletal Muscle and Adipose Tissue

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 4, August 2026.
ABSTRACT Background The serine/threonine kinase AKT is a key regulator of glucose and energy metabolism. Prevailing dogma suggests that AKT is an obligate intermediate for glucose uptake in all metabolic tissues and that impaired AKT signalling is a major molecular driver of insulin resistance in obesity.
Natasha Jaiswal, Matthew Gavin, Louise Lantier, Olivia Yu Yu Ong, David H. Wasserman, Paul M. Titchenell   +5 more
wiley   +1 more source

Mitoquinone Prevents Cardiac Dysfunction by Normalizing Mitochondrial ROS and Calcium Handling in Acute Myocardial Infarction

Acta Physiologica, Volume 242, Issue 8, August 2026.
ABSTRACT Acute myocardial infarction (MI) is the leading cause of heart failure (HF). However, the role of mitochondrial ROS (ROSm) in early MI dysfunction remains unclear. This study aimed to evaluate the impact of MitoQ on cardiac function in cases of heart HF following MI.
Carolina Falcão Ximenes, Pietra Zava Lorencini, Carmen Castardeli, Marlon Ramos Rosado Machado, Katyana Kaline Silva Ferreira, Sara Bianca Oliveira Mendes, Anna Karolina Nascimento Costa, Mario Morais Silva, Sérgio Ricardo Aluotto Scalzo, Marcos Eliezeck, Silvia Guatimosim, Eduardo Hertel Ribeiro, Donald M. Bers, Aurélia Araujo Fernandes, Ivanita Stefanon   +14 more
wiley   +1 more source

Type-1 Ryanodine Receptor Plays an Important Role in Cardiac Hypertrophy and Heart Failure by Increasing Type-2 Ryanodine Receptor-Mediated Calcium Release. [PDF]

Int J Mol Sci
Wang YX, Santos EW, Mistretta S, Yuan Y, Singer HA, Sheu SS, Zheng YM.   +6 more
europepmc   +1 more source

A novel selective stabilizer of the ryanodine receptor 2 prevents stress‐induced ventricular arrhythmias without impairing cardiac function

British Journal of Pharmacology, Volume 183, Issue 15, Page 4321-4343, August 2026.
Abstract Background and Purpose Aberrant activation of type 2 ryanodine receptors (RyR2) causes lethal arrhythmias, such as catecholaminergic polymorphic ventricular tachycardia (CPVT). Developing drugs that suppress RyR2 hyperactivation may be key to novel arrhythmia treatments.
Nagomi Kurebayashi, Masami Kodama, Hana Inoue, Masato Konishi, Masami Sugihara, Takashi Murayama, Ryosuke Ishida, Koichiro Ishii, Shuichi Mori, Yukari Endo, Xi Zeng, Yukiko U. Inoue, Takayoshi Inoue, Satoru Noguchi, Hajime Nishio, Eri Nakashima, Norio Suzuki, Noriko Nakaya, Ryushi Sato, Yuya Otori, Ayuna Tsutsumi, Mirei Takahashi, Takayuki Oka, Haruo Ogawa, Kayoko Kanamitsu, Hiroyuki Kusuhara, Utako Yokoyama, Junko Kurokawa, Hiroyuki Kagechika, Takashi Sakurai   +29 more
wiley   +1 more source

A new Fight-or-Flight Pacemaker Mechanism via Ryanodine Receptor abundance and superclustering. [PDF]

PLoS Comput Biol
Ventura Subirachs V, Tagirova S, Maltsev AV, Yang D, Lakatta EG, Stern MD, Maltsev VA.   +6 more
europepmc   +1 more source