Results 111 to 120 of about 2,688,953 (298)

Ethyl 3-bromo-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxylate

Acta Crystallographica Section E, 2009
The title compound, C11H9BrClN3O2, is an intermediate in the synthesis of Rynaxypyre, a new insecticidal anthranilic diamide used as a potent and selective ryanodine receptor activator. The dihedral angle between the aromatic ring planes is 78.7 (2)
Hai-Bing He, Shan Liu, Hai-Jun Tan, Ming Xia, Hong-Jun Zhu   +4 more
doaj   +1 more source

Rieske iron-sulfur protein induces FKBP12.6/RyR2 complex remodeling and subsequent pulmonary hypertension through NF-κB/cyclin D1 pathway

Nature Communications, 2020
Pulmonary hypertension is a devastating disease with elevation of pulmonary artery pressure and related to abnormal calcium signalling. Here, the authors show that suppression or stabilization of the calcium channel ryanodine receptor 2 may be a ...
Lin Mei, Yun-Min Zheng, Tengyao Song, Vishal R. Yadav, Leroy C. Joseph, Lillian Truong, Sharath Kandhi, Margarida M. Barroso, Hiroshi Takeshima, Marc A. Judson, Yong-Xiao Wang   +10 more
doaj   +1 more source

Targeting Intracellular Calcium Stores Alleviates Neurological Morbidities in a DFP-Based Rat Model of Gulf War Illness [PDF]

, 2019
Gulf War Illness (GWI) is a chronic multi-symptom disorder afflicting the veterans of the First Gulf War, and includes neurological symptoms characterized by depression and memory deficits.
Blair, Robert, Deshpande, Laxmikant, Phillips, Kristin, Santos, Edna   +3 more
core   +1 more source

Disease mutations in the ryanodine receptor N-terminal region couple to a mobile intersubunit interface

Nature Communications, 2013
Ryanodine receptors are large channels that release Ca2+ from the endoplasmic and sarcoplasmic reticulum. Hundreds of RyR mutations can cause cardiac and skeletal muscle disorders, yet detailed mechanisms explaining their effects have been lacking.
Lynn Kimlicka, K. Lau, Ching‐Chieh Tung, F. van Petegem   +3 more
semanticscholar   +1 more source

Sympathetic stimulation can compensate for hypocalcaemia‐induced bradycardia in human and rabbit sinoatrial node cells

The Journal of Physiology, EarlyView.
Abstract figure legend AC: adenylyl cyclase, APT: adenosine triphosphate, AMP: adenosine monophosphate, cAMP: cyclic adenosine monophosphate, PDE: phosphodiesterase, PKA: protein kinase A, PPT: protein phosphatase, P: phosphorylation, RyR: ryanodine receptor, SERCA: sarcoplasmic/endoplasmic reticulum Ca2+‐adenosine triphosphatase, SR: sarcoplasmic ...
Moritz Linder, Tomas Stary, Gergő Bitay, Norbert Nagy, Axel Loewe   +4 more
wiley   +1 more source

Fluorescent Probes for Insect Ryanodine Receptors: Candidate Anthranilic Diamides

Molecules, 2014
Diamide insecticides with high efficacy against pests and good environmental safety are broadly applied in crop protection. They act at a poorly-defined site in the very complex ryanodine (Ry) receptor (RyR) potentially accessible to a fluorescent probe.
Yi Wang, Lei Guo, Suzhen Qi, Hao Zhang, Kechang Liu, Ruiquan Liu, Pei Liang, John E. Casida, Shangzhong Liu   +8 more
doaj   +1 more source

TMEM16A channel signalling microdomains in the regulation of vascular function

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic representation of TMEM16A channel signalling microdomains. Calcium influx or calcium release from the endoplasmic/sarcoplasmic reticulum (ER/SR) activates TMEM16A channels through interactions with regulatory proteins in vascular smooth muscle cells or endothelial cells. TMEM16A channel activation drives chloride efflux,
Fênix Araujo, Swapnil K. Sonkusare
wiley   +1 more source

Impaired neutrophil directional chemotactic accuracy in chronic periodontitis patients [PDF]

, 2015
Aim: To investigate the chemotactic accuracy of peripheral blood neutrophils from patients with chronic periodontitis compared with matched healthy controls, before and after non-surgical periodontal therapy.
Agarwal, Andrew, Bagorda, Berridge, Biemond, Bostan, Brock, Cedergren, Champagne, Chapple, Chapple, Chapple, Choi, Clark, Cooper, Cotter, Daniel, Dias, Dias, Dias, Dickinson, Dietrich, Dyke, Dyke, Dyke, Dyke, Dyke, Fu, Fujita, Gamonal, Graves, Grossi, Haastert, Harvath, Henry, Herlihy, Herlihy, Kantarci, Kaul, Kolaczkowska, Kuiper, Kumar, Kurihara, Lakshman, Lambeth, Lavine, Matthews, Matthews, Miesel, Mizuno, Muinonen-Martin, Nibali, Niethammer, Nishizuka, Offenbacher, Pablo, Page, Partida-Sanchez, Phillips, Rahman, Sackmann, Samanta, Sapey, Toker, Tsai, Tyagi, Van Dyke, Wells, Worthen, Wright, Yagi, Yoshikawa, Zigmond   +72 more
core   +2 more sources

Ryanodine Receptor Blockade Reduces Amyloid-β Load and Memory Impairments in Tg2576 Mouse Model of Alzheimer Disease

Journal of Neuroscience, 2012
In Alzheimer disease (AD), the perturbation of the endoplasmic reticulum (ER) calcium (Ca2+) homeostasis has been linked to presenilins, the catalytic core in γ-secretase complexes cleaving the amyloid precursor protein (APP), thereby generating amyloid ...
B. Oulès, D. Del Prete, B. Greco, Xuexin Zhang, Inger Lauritzen, J. Sévalle, Sébastien Moreno, P. Paterlini-Bréchot, M. Trebak, F. Checler, F. Benfenati, M. Chami   +11 more
semanticscholar   +1 more source

Calcium‐activated chloride channels in pericytes and their role in regulating organ blood flow

The Journal of Physiology, EarlyView.
Abstract figure legend Pericytes are microvascular mural cells with diverse roles. Contractile pericytes directly regulate local perfusion, while non‐contractile pericytes coordinate upstream vascular contractility via propagating electrical signals.
Paolo Tammaro, Hikaru Hashitani
wiley   +1 more source