Results 201 to 210 of about 49,122 (245)

Ca2+ signalling in cardiac muscle: the importance of balances. [PDF]

Europace
Niggli E, Gomez AM.
europepmc   +1 more source

Structural basis for simvastatin-induced skeletal muscle weakness associated with type 1 ryanodine receptor T4709M mutation. [PDF]

J Clin Invest
Weninger G, Dridi H, Reiken S, Yuan Q, Zhao N, Groom L, Leigh J, Liu Y, Tchagou C, Kang J, Chang A, Luna-Figueroa E, Miotto MC, Wronska A, Dirksen RT, Marks AR.   +15 more
europepmc   +1 more source

Statins, skeletal muscle, and ryanodine receptor activation: resolving a 30-year mystery behind statin myotoxicity. [PDF]

Cardiovasc Diabetol Endocrinol Rep
Santulli G.
europepmc   +1 more source

Large-scale high-throughput screen for cardiac ryanodine receptor targeted therapeutics. [PDF]

J Biol Chem
Nikolaienko R, Bovo E, Solberg JC, Brinkmann M, Treinen LM, Thompson AR, Berg K, Thomas DD, Thomas JJ, Bers DM, Aldrich CC, Zima AV, Cornea RL, Rebbeck RT.   +13 more
europepmc   +1 more source

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Blocking effect of ferritin on the ryanodine receptor-isoform 2

Archives of Biochemistry and Biophysics, 2021
Iron, an essential element for most living organism, participates in a wide variety of physiological processes. Disturbance in iron homeostasis has been associated with numerous pathologies, particularly in the heart and brain, which are the most susceptible organs.
Marta Gaburjáková, Jana Gaburjáková, Eva Krejčíová, Daniel Kosnáč, Helena Kosnáčová, Štefan Nagy, Štefan Polák, Michal Sabo, Michal Trnka, Martin Kopáni   +9 more
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Modulation of cardiac ryanodine receptor 2 by calmodulin

Nature, 2019
The high-conductance intracellular calcium (Ca2+) channel RyR2 is essential for the coupling of excitation and contraction in cardiac muscle. Among various modulators, calmodulin (CaM) regulates RyR2 in a Ca2+-dependent manner. Here we reveal the regulatory mechanism by which porcine RyR2 is modulated by human CaM through the structural determination ...
Deshun, Gong, Ximin, Chi, Jinhong, Wei, Gewei, Zhou, Gaoxingyu, Huang, Lin, Zhang, Ruiwu, Wang, Jianlin, Lei, S R Wayne, Chen, Nieng, Yan   +9 more
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Pyrrole-2 carboxamides - A novel class of insect ryanodine receptor activators

Pesticide Biochemistry and Physiology, 2021
The ryanodine receptor (RyR) is an intracellular calcium channel critical to the regulation of insect muscle contraction and the target site of diamide insecticides such as chlorantraniliprole, cyantraniliprole and flubendiamide. To-date, diamides are the only known class of synthetic molecules with high potency against insect RyRs.
Daniel, Cordova, Eric A, Benner, David A, Clark, Stephen P, Bolgunas, George P, Lahm, Steven, Gutteridge, Daniel F, Rhoades, Lihong, Wu, Jeffrey S, Sopa, James J, Rauh, James D, Barry   +10 more
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A novel ryanodine receptor expressed in pancreatic islets by alternative splicing from type 2 ryanodine receptor gene

Biochemical and Biophysical Research Communications, 2010
Cyclic ADP-ribose (cADPR), a potent Ca(2+) mobilizing intracellular messenger synthesized by CD38, regulates the opening of ryanodine receptors (RyRs). Increases in intracellular Ca(2+) concentrations in pancreatic islets, resulting from Ca(2+) mobilization from RyRs as well as Ca(2+) influx from extracellular sources, are important in insulin ...
Shin, Takasawa, Michio, Kuroki, Koji, Nata, Naoya, Noguchi, Takayuki, Ikeda, Akiyo, Yamauchi, Hiroyo, Ota, Asako, Itaya-Hironaka, Sumiyo, Sakuramoto-Tsuchida, Iwao, Takahashi, Takeo, Yoshikawa, Tooru, Shimosegawa, Hiroshi, Okamoto   +12 more
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