Results 211 to 220 of about 49,122 (245)

The Role of Ryanodine Receptor 2 in Drug-Associated Learning

2023
AbstractType-2 ryanodine receptor (RyR2) ion channels facilitate the release of Ca2+from stores and serve an important function in neuroplasticity. The role for RyR2 in hippocampal-dependent learning and memory is well established and chronic hyperphosphorylation of RyR2 (RyR2P) is associated with pathological calcium leakage and cognitive disorders ...
Kara R. Barber, Velia S. Vizcarra, Ashlyn Zilch, Lisa Majuta, Cody C. Diezel, Oliver P. Culver, Brandon W. Hughes, Makoto Taniguchi, John M. Streicher, Todd W. Vanderah, Arthur C. Riegel   +10 more
openaire   +2 more sources

Multiple ryanodine receptor subtypes and heterogeneous ryanodine receptor-gated Ca²⁺stores in pulmonary arterial smooth muscle cells

American Journal of Physiology-Lung Cellular and Molecular Physiology, 2005
Ryanodine receptors (RyRs) of pulmonary arterial smooth muscle cells (PASMCs) play important roles in major physiological processes such as hypoxic pulmonary vasoconstriction and perinatal pulmonary vasodilatation. Recent studies show that three subtypes of RyRs are coexpressed and RyR-gated Ca2+stores are distributed heterogeneously in systemic ...
Lin, MJ, Yang, XR, Jeyakumar, LH, Leung, GPH, Fleischer, S, Sham, JSK, Yip, KP   +6 more
openaire   +4 more sources

Cardiac Calcium Release Channel (Ryanodine Receptor 2) Regulation by Halogenated Anesthetics

Anesthesiology, 2017
Abstract Background Halogenated anesthetics activate cardiac ryanodine receptor 2–mediated sarcoplasmic reticulum Ca2+ release, leading to sarcoplasmic reticulum Ca2+ depletion, reduced cardiac function, and providing cell protection against ischemia-reperfusion injury. Anesthetic activation of ryanodine receptor 2 is
Laver, Derek R., Attia, John, Oldmeadow, Christopher, Quail, Anthony W.   +3 more
openaire   +2 more sources

Ca²⁺influx through the osteoclastic plasma membrane ryanodine receptor

American Journal of Physiology-Renal Physiology, 2002
We predict that the type 2 ryanodine receptor isoform (RyR-2) located in the osteoclastic membrane functions as a Ca2+influx channel and as a divalent cation (Ca2+) sensor. Cytosolic Ca2+measurements revealed Ca2+influx in osteoclasts at depolarized membrane potentials.
Baljit S, Moonga, Sun, Li, Jameel, Iqbal, Robert, Davidson, Vijai S, Shankar, Peter J R, Bevis, Angela, Inzerillo, Etsuko, Abe, Christopher L-H, Huang, Mone, Zaidi   +9 more
openaire   +2 more sources

Functional Characterization of 2 Known Ryanodine Receptor Mutations Causing Malignant Hyperthermia

Anesthesia & Analgesia, 2014
Malignant hyperthermia (MH) is a potentially lethal pharmacogenetic disorder. More than 300 variants in the ryanodine receptor 1 (RYR1) have been associated with MH; however, only 31 have been identified as causative. To confirm a mutation in RYR1 as being causative for MH, segregation of the potential mutation in at least 2 unrelated families with MH ...
Anja H, Schiemann, Neeti, Paul, Remai, Parker, Neil, Pollock, Terasa F, Bulger, Kathryn M, Stowell   +5 more
openaire   +2 more sources

Ryanodine receptor-mediated interference of neuronal cell differentiation by presenilin 2 mutation

Journal of Neuroscience Research, 2005
Neuronal cell differentiation alterations induced by mutant presenilin 2 (PS2) were investigated in transgenic mice expressing wild-type or mutant-type PS2. Progressive increases in differentiation and marker protein expression were found in neuronal cells expressing wild-type PS2, whereas these processes were much perturbed in mutant-type PS2 with ...
Sang Min, Lee, Jae Woong, Lee, Youn Sook, Song, Dae Youn, Hwang, Yong Kyu, Kim, Sang Yun, Nam, Dae Joong, Kim, Young Won, Yun, Do Young, Yoon, Jin Tae, Hong   +9 more
openaire   +2 more sources

Distribution of ryanodine receptor Ca2+ channels in insect photoreceptor cells

The Journal of Comparative Neurology, 2000
Physiological studies have provided evidence for the existence of ryanodine receptor (RyR) Ca(2+) channels in compound eyes of insects. The present study identifies and localizes RyR in insect photoreceptors by use of an affinity-purified antibody against lobster muscle RyR.
openaire   +3 more sources

Systemic therapy for hormone receptor‐positive/human epidermal growth factor receptor 2‐negative early stage and metastatic breast cancer

Ca-A Cancer Journal for Clinicians, 2023
Laura A Huppert, Hope S Rugo
exaly  

Critical care management of chimeric antigen receptor T‐cell therapy recipients

Ca-A Cancer Journal for Clinicians, 2022
Alexander Shimabukuro-Vornhagen, Boris Böll, Peter Schellongowski   +2 more
exaly  

Chimeric antigen receptor T‐cell therapy in multiple myeloma: A comprehensive review of current data and implications for clinical practice

Ca-A Cancer Journal for Clinicians, 2023
Rujul Parikh, Sagar Lonial
exaly