Results 111 to 120 of about 4,095,708 (243)

Translating cardiovascular ion channel and Ca2+ signalling mechanisms into therapeutic insights

The Journal of Physiology, EarlyView.
Abstract figure legend This white paper integrates mechanistic discoveries across ion channel biology, Ca2+ signalling and multiscale cardiovascular physiology to highlight new opportunities for accelerating research and guiding next‐generation therapies. Printed with permission from ®Anita Impagliazzo Medical Illustration. [Correction added on 2 March
Silvia Marchianò, Miguel Martín‐Aragón Baudel, Charlotte E. R. Smith, Gonzalo Hernandez Hernandez, Donald M. Bers, Patrick M. Boyle, Dobromir Dobrev, Shanna Hamilton, Osama F. Harraz, Na Li, Thomas A. Longden, William E. Louch, Madeline Nieves‐Cintron, Matthew A. Nystoriak, Walter Lee Murfee, Przemysław B. Radwański, Swapnil K. Sonkusare, Manuel F. Navedo, Eleonora Grandi   +18 more
wiley   +1 more source

When NCX switches sides: Experimental and computational insights into Ca2+ regulation in the heart

The Journal of Physiology, EarlyView.
Abstract figure legend Due to its presence inside the dyadic cleft, Na+/Ca2+ exchanger (NCX) builds a functional unit together with L‐type calcium channels and ryanodine receptors in the dyadic cleft. NCX acts bidirectionally (forward and reverse mode) dependent on extracellular calcium ([Ca2+]o) and sodium ([Na+]o) concentrations and the membrane ...
Wilhelm Neubert, Judith Hüttemeister, Paulina Sander, Nagaiah Chamakuri, Felix Hohendanner, Martin Falcke, Frank R. Heinzel   +6 more
wiley   +1 more source

PKA Phosphorylation Dissociates FKBP12.6 from the Calcium Release Channel (Ryanodine Receptor) Defective Regulation in Failing Hearts [PDF]

, 2000
The ryanodine receptor (RyR)/calcium release channel on the sarcoplasmic reticulum (SR) is the major source of calcium (Ca2+) required for cardiac muscle excitation-contraction (EC) coupling.
Hisamatsu, Yuji, Burkhoff, Daniel, Marks, Andrew R, Rosemblit, Nora, Marx, Steven O, Jayaraman, Thotalla, Reiken, Steven   +6 more
core   +1 more source

SH Oxidation Stimulates Calcium Release Channels (Ryanodine Receptors) From Excitable Cells

Biological Research, 2000
The effects of redox reagents on the activity of the intracellular calcium release channels (ryanodine receptors) of skeletal and cardiac muscle, or brain cortex neurons, was examined. In lipid bilayer experiments, oxidizing agents (2,2'-dithiodipyridine or thimerosal) modified the calcium dependence of all single channels studied.
Hidalgo Tapia, María Cecilia, Bull Simpfendorfer, Ricardo, Marengo, Juan J., Perez, Claudio F., Donoso Laurent, Paulina   +4 more
openaire   +7 more sources

An age‐associated decline in the role of the sarcoplasmic reticulum and associated calcium‐handling proteins sets the pace for sinoatrial node function

The Journal of Physiology, EarlyView.
Abstract figure legend Stable, responsive pacemaking in the sinoatrial node is driven by the activity of the funny current (membrane clock), interplay of calcium cycling and release from the sarcoendoplasmic reticulum with depolarising sodium‐calcium exchange current (calcium clock). With increasing age, key proteins associated with calcium cycling are
Sandra A. Jones, Fiona S. Godbeer, Matthew K. Lancaster   +2 more
wiley   +1 more source

Tissue-specific expression of calcium channels [PDF]

, 1993
The high-voltage-activated calcium channel is a multimeric protein complex containing 1, 2/δ, β, and γ subunits. The 1 subunit is the ion conduction channel and contains the binding sites for calcium channel blockers and toxins.
Flockerzi, Veit, Biel, Martin, Hullin, Roger, Hofmann, Franz   +3 more
core   +1 more source

The interplay between dynamic regulation of ion‐channel gating and trafficking in cardiac arrhythmogenesis

The Journal of Physiology, EarlyView.
Abstract figure legend Cardiac cellular electrophysiology is modulated by multiple factors, including temperature, extracellular K+, heart rate/pacing frequency, and drugs. These modulators can have distinct effects on ion‐channel gating and transcription/trafficking over time.
Stefan Meier, Anna S. Savchenko, Paul G. A. Volders, Jordi Heijman   +3 more
wiley   +1 more source

Cooperative calcium and zinc signaling underlies oxidant-induced neuronal injury [PDF]

, 2013
Intracellular zinc release triggered by oxidative injury leads to cellular K+ efflux and neuronal apoptosis. Low intracellular K+ enables protease and nuclease activation during cell death processes. Our laboratory has demonstrated that the reduction in
McCord, Meghan
core  

ER localized bestrophin1 activates Ca2+ dependent ion channels TMEM16A and SK4 [PDF]

, 2009
Bestrophins form Ca2+ activated Cl- channels and regulate intercellular Ca2+ signaling1. We demonstrate that bestrophin 1 is localized in the endoplasmic reticulum (ER), where it physically interacts with stromal interacting molecule 1 (Stim1), the ER ...
Rainer Schreiber, Fadi AlDehni, Kunzelmann, Karl, Ousingsawat, Jiraporn, René Barro-Soria, Karl Kunzelmann, Joana Almaça, Jiraporn Ousingsawat, Schreiber, Rainer, AlDehni, Fadi, Barro-Soria, René, Almaça, Joana, Ralph Witzgall, Witzgall, Ralph   +13 more
core   +1 more source

El acoplamiento excitación-contracción en el músculo esquelético: preguntas por responder a pesar de 50 años de estudio

Biomédica: revista del Instituto Nacional de Salud, 2009
El mecanismo de acoplamiento excitación-contracción fue definido en el músculo esquelético como la secuencia de eventos que ocurre desde la generación del potencial de acción en la fibra muscular hasta que se inicia la generación de tensión.
Juan Camilo Calderón-Vélez, Lourdes Carolina Figueroa-Gordon   +1 more
doaj   +1 more source