Results 111 to 120 of about 28,867 (291)
A Rare Case of Severe Congenital RYR1-Associated Myopathy
Case Reports in Genetics, 2018 Congenital myopathies are a group of rare inherited diseases, defined by hypotonia and muscle weakness. We report clinical and genetic characteristics of a male preterm newborn, whose phenotype was characterized by severe hypotonia and hyporeactivity ...
Nicola Laforgia +8 more
doaj +1 more source
β-adrenergic inhibition prevents action potential and calcium handling changes during regional myocardial ischemia [PDF]
, 2017 β-adrenergic receptor (β-AR) blockers may be administered during acute myocardial infarction (MI), as they reduce energy demand through negative chronotropic and inotropic effects and prevent ischemia-induced arrhythmogenesis. However, the direct effects
Domondon, Philip +7 more
core +3 more sources
Update on cellular expression and function of ANO1 channels in urethral smooth muscle
The Journal of Physiology, EarlyView.Abstract figure legend Activation of ANO1 channels and resulting Cl− efflux are suggested to modulate urethral smooth muscle contractility by enhancing Ca2+ influx via voltage‐dependent Ca2+ entry and resulting contraction in urethral smooth muscle cells.
Bernard T. Drumm, Neha Gupta
wiley +1 more source
BiosensorsThe homeostasis of cellular calcium is fundamental for many physiological processes, while the calcium levels remain inhomogeneous within cells. During the onset of asthma, epithelial and inflammatory cells secrete platelet-derived growth factor (PDGF ...
Mingxing Ouyang +3 more
doaj +1 more source
Physiological Reports, 2019 Cardiac Purkinje cells (PCs) are more susceptible to action potential abnormalities as compared to ventricular myocytes (VMs), which could be associated with their distinct intracellular calcium handling.
Chirag Shah +4 more
doaj +1 more source
Characterization of Forskolin-Induced Ca2+ Signals in Rat Olfactory Receptor Neurons
Journal of Pharmacological Sciences, 2005 Forskolin-induced Ca2+ signals were examined in isolated rat olfactory receptor neurons (ORNs) using a Ca2+ indicator, fura-2. In the soma of the ORNs, forskolin caused an increase in the intracellular Ca2+ concentration ([Ca2+]i) that was enhanced by a ...
Ken-ichi Otsuguro +4 more
doaj +1 more source
Structural and functional conservation of key domains in InsP3 and ryanodine receptors. [PDF]
, 2012 Inositol-1,4,5-trisphosphate receptors (InsP(3)Rs) and ryanodine receptors (RyRs) are tetrameric intracellular Ca(2+) channels. In each of these receptor families, the pore, which is formed by carboxy-terminal transmembrane domains, is regulated by ...
Ames, James B +10 more
core +1 more source
Mathematical model of the zebrafish ventricular cardiomyocyte action potential and calcium transient
The Journal of Physiology, EarlyView.Abstract figure legend This study presents the development and validation of the first biophysically detailed computational model of the zebrafish ventricular action potential (AP). The model is based on a human cardiomyocyte framework and reparameterized using published and newly generated patch‐clamp recordings of zebrafish ionic currents.
Ludovica Cestariolo +5 more
wiley +1 more source
Foot protein isoforms are expressed at different times during embryonic chick skeletal muscle development. [PDF]
, 1991 We have investigated the time course of expression of the alpha and beta triad junctional foot proteins in embryonic chick pectoral muscle. The level of [3H]ryanodine binding in muscle homogenates is low until day E20 of embryonic development, then ...
Airey, JA +6 more
core +1 more source
Physiology and Pathology of Calcium Signaling in the Brain [PDF]
, 2012 Calcium (Ca2+) plays fundamental and diversified roles in neuronal plasticity. As second messenger of many signaling pathways, Ca2+ as been shown to regulate neuronal gene expression, energy production, membrane excitability, synaptogenesis, synaptic ...
Elisa Mitiko Kawamoto +2 more
core +2 more sources