Results 171 to 180 of about 28,867 (291)

Annual Banned‐Substance Review 18th Edition—Analytical Approaches in Human Sports Drug Testing 2024/2025

open access: yesDrug Testing and Analysis, Volume 18, Issue 4, Page 458-482, April 2026.
New insights into drug metabolism, distribution, elimination, and detection assays for drugs and methods of sports doping published between 2024 and 2025 are critically reviewed and evaluated in context with the Prohibited List 2025 as established by the World Anti‐Doping Agency.
Mario Thevis, Tiia Kuuranne, Hans Geyer
wiley   +1 more source

Mitochondrial Ca2+ overload is a pivotal risk factor for lethal ventricular arrhythmias due to the oxidation of mitochondrial respirasome and energetic failure

open access: yesBritish Journal of Pharmacology, Volume 183, Issue 7, Page 1404-1426, April 2026.
The data that support the findings of this study are available from the corresponding author upon reasonable request. Some data may not be made available because of privacy or ethical restrictions. Background and Purpose Ventricular arrhythmias are a leading cause of death among patients with cardiovascular diseases and are associated with elevated ...
Felipe de Jesús Salazar‐Ramírez   +13 more
wiley   +1 more source

Dystrophin Threshold Level Necessary for Normalization of Neuronal Nitric Oxide Synthase, Inducible Nitric Oxide Synthase, and Ryanodine Receptor-Calcium Release Channel Type 1 Nitrosylation in Golden Retriever Muscular Dystrophy Dystrophinopathy

open access: green, 2016
Christel Gentil   +11 more
openalex   +2 more sources

The GPCR Connection: Linking Alzheimer's Disease and Glioblastoma

open access: yesJournal of Cellular and Molecular Medicine, Volume 30, Issue 7, April 2026.
ABSTRACT Alzheimer's disease (AD) and glioblastoma multiforme (GBM) are biologically distinct age‐related brain disorders with opposing clinical phenotypes. AD is characterised by progressive neurodegeneration and cognitive decline, whereas GBM is characterised by aggressive cellular proliferation and a poor prognosis.
Ana B. Caniceiro   +4 more
wiley   +1 more source

The Role of Loss‐of‐Function KCNH2 Variants in Cardiac Arrhythmias, Seizures and the Risk of Sudden Unexpected Death in Epilepsy

open access: yesJournal of Neurochemistry, Volume 170, Issue 4, April 2026.
Seizures can trigger a surge in brain‐driven autonomic signals, causing dangerous changes in heart rhythm and breathing. This ‘storm’ increases stress on the heart, leading to prolonged QT intervals and arrhythmias, while also slowing breathing and causing low oxygen levels. When these effects occur together, they create a vicious cycle that can result
Hian M. Lee   +5 more
wiley   +1 more source

Type III CD38 is present in the membrane of neurosecretory vesicles and has a cytosol‐facing catalytic domain in primate oxytocin neurons

open access: yesJournal of Neuroendocrinology, Volume 38, Issue 4, April 2026.
Abstract CD38, an ADP‐ribosyl cyclase that generates cyclic ADP‐ribose (cADPR), is essential for Ca2+‐dependent oxytocin release. However, its subcellular localisation and membrane topology within oxytocin neurones have remained unclear. We investigated the distribution and orientation of CD38 in oxytocin‐producing neurones of Japanese macaques (Macaca
Tatsuki Miyamoto   +6 more
wiley   +1 more source

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