Results 251 to 260 of about 28,867 (291)

The brain ryanodine receptor: A caffeine-sensitive calcium release channel

Neuron, 1991
The release of stored Ca2+ from intracellular pools triggers a variety of important neuronal processes. Physiological and pharmacological evidence has indicated the presence of caffeine-sensitive intracellular pools that are distinct from the well-characterized inositol 1,4,5,-trisphosphate (IP3)-gated pools.
P S, McPherson, Y K, Kim, H, Valdivia, C M, Knudson, H, Takekura, C, Franzini-Armstrong, R, Coronado, K P, Campbell   +7 more
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Stabilization of calcium release channel (ryanodine receptor) function by FK506-binding protein

Cell, 1994
FK506-binding protein (FKBP12) was originally identified as the cytosolic receptor for the immunosuppressant drugs FK506 and rapamycin. The cellular function of FKBP12, a ubiquitously expressed 12,000-dalton proline isomerase, has been unknown. FKBP12 copurifies with the 565,000-dalton ryanodine receptor (RyR), four of which form intracellular Ca2 ...
A B, Brillantes, K, Ondrias, A, Scott, E, Kobrinsky, E, Ondriasová, M C, Moschella, T, Jayaraman, M, Landers, B E, Ehrlich, A R, Marks   +9 more
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Ryanodine Receptor Calcium Release Channels

Physiological Reviews, 2002
The ryanodine receptors (RyRs) are a family of Ca2+release channels found on intracellular Ca2+storage/release organelles. The RyR channels are ubiquitously expressed in many types of cells and participate in a variety of important Ca2+signaling phenomena (neurotransmission, secretion, etc.).
Michael, Fill, Julio A, Copello
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Physical Coupling between Ryanodine Receptor–Calcium Release Channels

Journal of Molecular Biology, 2005
Ryanodine receptor-calcium release channels play a pivotal role in the calcium signaling that mediates muscle excitation-contraction coupling. Their membrane organization into regular patterns, functional gating studies and theoretical analysis of receptor clustering have led to models that invoke allosteric interaction between individual channel ...
Chang-Cheng, Yin, Lynda M, Blayney, F Anthony, Lai   +2 more
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Coupled Gating Between Cardiac Calcium Release Channels (Ryanodine Receptors)

Circulation Research, 2001
Abstract —Excitation-contraction coupling in heart muscle requires the activation of Ca 2+ -release channels/type 2 ryanodine receptors (RyR2s) by Ca 2+ influx. RyR2s are arranged on the sarcoplasmic reticular membrane in closely packed arrays such that their large cytoplasmic ...
S O, Marx, J, Gaburjakova, M, Gaburjakova, C, Henrikson, K, Ondrias, A R, Marks   +5 more
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Ryanodine receptor calcium release channels: lessons from structure–function studies

The FEBS Journal, 2013
Ryanodine receptors (RyRs) are the largest known ion channels. They are Ca2+ release channels found primarily on the sarcoplasmic reticulum of myocytes. Several hundred mutations in RyRs are associated with skeletal or cardiomyocyte disease in humans.
Fernando J, Amador, Peter B, Stathopulos, Masahiro, Enomoto, Mitsuhiko, Ikura   +3 more
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Regulation of Ryanodine Receptor Calcium Release Channels by Diadenosine Polyphosphates

Journal of Neurochemistry, 1996
Abstract: [3H]Ryanodine binding to, as well as functions of, ryanodine receptor intracellular Ca2+ release channel complexes are modulated by several adenosine‐based compounds. In this study, we determined the effects of endogenous compounds termed diadenosine polyphosphates (ApnAs; n = 2–6 phosphate groups) on [3H]ryanodine binding to membranes ...
C P, Holden, R A, Padua, J D, Geiger
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Intrinsic lattice formation by the ryanodine receptor calcium-release channel

Nature Cell Biology, 2000
Recent theoretical analysis of a model lattice of interacting transmembrane receptor proteins has indicated that such clustering in the membrane could provide a novel mechanism for regulating receptor signalling in cells. It has been calculated that cooperative interactions between receptors organized into a cluster, or array, in the membrane would ...
C C, Yin, F A, Lai
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Cardiac Calcium Release Channel (Ryanodine Receptor 2) Regulation by Halogenated Anesthetics

Anesthesiology, 2017
Abstract Background Halogenated anesthetics activate cardiac ryanodine receptor 2–mediated sarcoplasmic reticulum Ca2+ release, leading to sarcoplasmic reticulum Ca2+ depletion, reduced cardiac function, and providing cell protection against ischemia-reperfusion injury. Anesthetic activation of ryanodine receptor 2 is
Laver, Derek R., Attia, John, Oldmeadow, Christopher, Quail, Anthony W.   +3 more
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Regulation of Ryanodine Receptor Calcium Release Channels

2000
Ryanodine receptor (RyR)/calcium release channel is one of the two major classes of intracellular calcium release channels, the other being IP3receptor described in the Chap. 24. RyRs are present in the membrane of the intracellular calcium store, usually endoplasmic reticulum, in almost every kind of cell and, by its opening, it provides a path ...
M. Endo, T. Ikemoto
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