Results 271 to 280 of about 28,867 (291)
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Calcium Ion Permeation through the Calcium Release Channel (Ryanodine Receptor) of Cardiac Muscle
The Journal of Physical Chemistry B, 2003Single-channel current−voltage (IV) relations were measured from the calcium release channel of cardiac sarcoplasmic reticulum (RyR2) in 21 mixed solutions of 250 mM alkali metal ions (Na+, K+, and Cs+) with sarcoplasmic reticulum lumenal Ca++ ranging from 5 to 50 mM and Mg++ from 1 to 50 mM.
Duan P. Chen +3 more
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Molecular Insights into Calcium Dependent Regulation of Ryanodine Receptor Calcium Release Channels
2019Ryanodine receptor calcium release channels (RyRs) play central roles in controlling intracellular calcium concentrations in excitable and non-excitable cells. RyRs are located in the sarcoplasmic or endoplasmic reticulum, intracellular Ca2+ storage compartment, and release Ca2+ during cellular action potentials or in response to other cellular stimuli.
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Ryanodine Receptors/Calcium Release channels in Heart Failure and Sudden Cardiac Death
Journal of Molecular and Cellular Cardiology, 2001Calcium (Ca2+) ions are second messengers in signaling pathways in all types of cells. They regulate muscle contraction, electrical signals which determine the cardiac rhythm and cell growth pathways in the heart. In the past decade cDNA cloning has provided clues as to the molecular structure of the intracellular Ca2+ release channels (ryanodine ...
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Activation of the Cardiac Calcium Release Channel (Ryanodine Receptor) by Poly-S-Nitrosylation
Science, 1998Several ion channels are reportedly redox responsive, but the molecular basis for the changes in activity is not known. The mechanism of nitric oxide action on the cardiac calcium release channel (ryanodine receptor) (CRC) in canines was explored. This tetrameric channel contains ∼84 free thiols and is S-nitrosylated in vivo.
L, Xu +3 more
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Biochemical and Biophysical Research Communications, 1988
The purified ryanodine receptor of heart sarcoplasmic reticulum (SR) has been reconstituted into planar phospholipid bilayers and found to form Ca2+-specific channels. The channels are strongly activated by Ca2+ (10 nM) in the presence of ATP (1 mM) and ryanodine, and inactivated by Mg2+ (3 mM) or ruthenium red (30 microM).
L, Hymel +3 more
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The purified ryanodine receptor of heart sarcoplasmic reticulum (SR) has been reconstituted into planar phospholipid bilayers and found to form Ca2+-specific channels. The channels are strongly activated by Ca2+ (10 nM) in the presence of ATP (1 mM) and ryanodine, and inactivated by Mg2+ (3 mM) or ruthenium red (30 microM).
L, Hymel +3 more
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Structural Details of the Ryanodine Receptor Calcium Release Channel and Its Gating Mechanism
2017Ryanodine receptors (RyRs) are large intracellular calcium release channels that play a crucial role in coupling excitation to contraction in both cardiac and skeletal muscle cells. In addition, they are expressed in other cell types where their function is less well understood.
Katrien, Willegems, Rouslan G, Efremov
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Society of General Physiologists series, 1996
The calcium-release channel/ryanodine receptor of the sarcoplasmic reticulum is a 2.3 million-D structure required for intracellular calcium release during excitation-contraction coupling in skeletal muscle. This structure is the largest ion channel characterized to date and is composed of four 565,000-D ryanodine receptors plus four molecules of ...
K, Ondrias +4 more
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The calcium-release channel/ryanodine receptor of the sarcoplasmic reticulum is a 2.3 million-D structure required for intracellular calcium release during excitation-contraction coupling in skeletal muscle. This structure is the largest ion channel characterized to date and is composed of four 565,000-D ryanodine receptors plus four molecules of ...
K, Ondrias +4 more
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Dysfunctional ryanodine receptor calcium release channels in Alzheimer's disease
Biochemical Society Transactions, 2000C. O'Neill +5 more
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