Results 131 to 140 of about 2,684,234 (246)

Statin activation of skeletal ryanodine receptors (RyR1) is a class effect but separable from HMG-CoA reductase inhibition. [PDF]

Br J Pharmacol, 2022
Lindsay C, Musgaard M, Russell AJ, Sitsapesan R.   +3 more
europepmc   +1 more source

The interplay between dynamic regulation of ion‐channel gating and trafficking in cardiac arrhythmogenesis

The Journal of Physiology, EarlyView.
Abstract figure legend Cardiac cellular electrophysiology is modulated by multiple factors, including temperature, extracellular K+, heart rate/pacing frequency, and drugs. These modulators can have distinct effects on ion‐channel gating and transcription/trafficking over time.
Stefan Meier, Anna S. Savchenko, Paul G. A. Volders, Jordi Heijman   +3 more
wiley   +1 more source

Dantrolene: A Selective Ryanodine Receptor Antagonist, Protects Against Pentylenetetrazole-Induced Seizure in Mice

Acta Medica Iranica, 2016
Ryanodine receptor abnormalities has implicated in the generation and maintenance of seizure. Dantrolene, a selective ryanodine receptor antagonist, may be a potential drug for the prevention of seizure.
Mojtaba Keshavarz, Morteza Fotouhi, Alireza Rasti   +2 more
doaj  

Inhibiting Calcium Release from Ryanodine Receptors Protects Axons after Spinal Cord Injury. [PDF]

J Neurotrauma, 2022
Orem BC, Rajaee A, Stirling DP.
europepmc   +1 more source

Multiscale mechanistic modelling of heterogeneity in cardiac sub‐cellular calcium handling accounting for variable t‐system density

The Journal of Physiology, EarlyView.
Abstract figure legend Illustration of spatial calcium dynamics (left panels) and the state cycle approximation (middle panel) that enables reduced simulation of spatially dependent dynamics without explicit description of space (right panels). The selected example here illustrates a spontaneous calcium wave, showing temporal snapshots of local calcium
Michael A Colman, Yohannes Shiferaw, David Conesa   +2 more
wiley   +1 more source

Modulation of Ryanodine Receptors Activity Alters the Course of Experimental Autoimmune Encephalomyelitis in Mice. [PDF]

Front Physiol, 2021
Osipchuk NC, Soulika AM, Fomina AF.
europepmc   +1 more source

Nonuniform and Variable Arrangements of Ryanodine Receptors Within Mammalian Ventricular Couplons

Circulation Research, 2014

semanticscholar   +1 more source

Sedentary ageing remodels the structure–function relationships that underlie calcium signalling at super‐resolution scales in the heart

The Journal of Physiology, EarlyView.
Abstract figure legend Illustration of calcium spark function and ryanodine receptor (RyR) structure within a sedentary model of ageing. Upon sympathetic stimulation from 1 µM isoprenaline a linear response to calcium spark morphology occurred, accompanied by a biphasic progression of RyR remodelling across age.
Miriam E. Hurley, David Conesa, Alan P. Benson, Michael A. Colman   +3 more
wiley   +1 more source

Nanoscale Organisation of Ryanodine Receptors and Junctophilin-2 in the Failing Human Heart. [PDF]

Front Physiol, 2021
Hou Y, Bai J, Shen X, de Langen O, Li A, Lal S, Dos Remedios CG, Baddeley D, Ruygrok PN, Soeller C, Crossman DJ.   +10 more
europepmc   +1 more source

Old dog, new trick: Charybdotoxin as a novel ryanodine receptor blocker

The Journal of Physiology, EarlyView.
Abstract figure legend The peptide toxin charybdotoxin (ChTx) from the scorpion Leiurus quinquestriatus was tested on single‐channel currents of the ryanodine receptor incorporated into planar lipid bilayers. The structure–function relationship of ChTx was investigated using toxin variants generated by isosteric substitutions of the basic amino acids ...
Zsuzsanna Édua Magyar, Judit Hevesi, Frigyes Mészáros, Zsolt Bozsó, János Szolomájer, Gábor Tóth, György Panyi, Péter Enyedi, Zoltán Varga, Zoltán Pethő, János Almássy   +10 more
wiley   +1 more source