Results 151 to 160 of about 2,684,234 (246)

Ryanodine receptors: structure, expression, molecular details, and function in calcium release.

Cold Spring Harbor Perspectives in Biology, 2010
J. Lanner, Dimitra K. Georgiou, A. Joshi, S. Hamilton   +3 more
semanticscholar   +1 more source

Mitoquinone Prevents Cardiac Dysfunction by Normalizing Mitochondrial ROS and Calcium Handling in Acute Myocardial Infarction

Acta Physiologica, Volume 242, Issue 8, August 2026.
ABSTRACT Acute myocardial infarction (MI) is the leading cause of heart failure (HF). However, the role of mitochondrial ROS (ROSm) in early MI dysfunction remains unclear. This study aimed to evaluate the impact of MitoQ on cardiac function in cases of heart HF following MI.
Carolina Falcão Ximenes, Pietra Zava Lorencini, Carmen Castardeli, Marlon Ramos Rosado Machado, Katyana Kaline Silva Ferreira, Sara Bianca Oliveira Mendes, Anna Karolina Nascimento Costa, Mario Morais Silva, Sérgio Ricardo Aluotto Scalzo, Marcos Eliezeck, Silvia Guatimosim, Eduardo Hertel Ribeiro, Donald M. Bers, Aurélia Araujo Fernandes, Ivanita Stefanon   +14 more
wiley   +1 more source

Rapid small-scale nanobody-assisted purification of ryanodine receptors for cryo-EM. [PDF]

J Biol Chem
Li C, Willegems K, Uchański T, Pardon E, Steyaert J, Efremov RG.   +5 more
europepmc   +2 more sources

Cyclic AMP-dependent regulation of ryanodine receptors in healthy and diseased hearts. [PDF]

J Mol Cell Cardiol
Hulsurkar MM, Ong I, Keefe JA, Abu-Taha IH, Dobrev D, Wehrens XHT.   +5 more
europepmc   +1 more source

A novel selective stabilizer of the ryanodine receptor 2 prevents stress‐induced ventricular arrhythmias without impairing cardiac function

British Journal of Pharmacology, Volume 183, Issue 15, Page 4321-4343, August 2026.
Abstract Background and Purpose Aberrant activation of type 2 ryanodine receptors (RyR2) causes lethal arrhythmias, such as catecholaminergic polymorphic ventricular tachycardia (CPVT). Developing drugs that suppress RyR2 hyperactivation may be key to novel arrhythmia treatments.
Nagomi Kurebayashi, Masami Kodama, Hana Inoue, Masato Konishi, Masami Sugihara, Takashi Murayama, Ryosuke Ishida, Koichiro Ishii, Shuichi Mori, Yukari Endo, Xi Zeng, Yukiko U. Inoue, Takayoshi Inoue, Satoru Noguchi, Hajime Nishio, Eri Nakashima, Norio Suzuki, Noriko Nakaya, Ryushi Sato, Yuya Otori, Ayuna Tsutsumi, Mirei Takahashi, Takayuki Oka, Haruo Ogawa, Kayoko Kanamitsu, Hiroyuki Kusuhara, Utako Yokoyama, Junko Kurokawa, Hiroyuki Kagechika, Takashi Sakurai   +29 more
wiley   +1 more source

Inactive ryanodine receptors sustain lysosomal availability for autophagy by promoting ER-lysosomal contact site formation. [PDF]

Nat Commun
Vervliet T, Loncke J, Sever M, Ahuja K, Van den Haute C, Luyten T, Stutzmann GE, Verfaillie C, Tomašič T, Bultynck G.   +9 more
europepmc   +1 more source

Development and analytical validation of a targeted short‐read next generation sequencing‐based pharmacogenetic panel for comprehensive variant detection

British Journal of Pharmacology, Volume 183, Issue 16, Page 4735-4760, August 2026.
Abstract Background and Purpose Genomic profiling of patients for genetic variants that modify the effect of specific medications has many benefits, including the possibility of avoiding toxicities and ensuring an adequate effect of the medication. Our intention was to develop a comprehensive, high‐quality pharmacogenetic test panel for clinical use ...
Anna Gréen, Nils Johan Fredriksson, Michael Andresen, Jon Jonasson, Malin Lindqvist Appell, Henrik Gréen   +5 more
wiley   +1 more source

Cryo-electron microscopy reveals sequential binding and activation of Ryanodine Receptors by statin triplets. [PDF]

Nat Commun
Molinarolo S, Valdivia CR, Valdivia HH, Van Petegem F.   +3 more
europepmc   +1 more source

Unraveling the ryanodine receptor

Biophysical Journal, 1994
openaire   +2 more sources

Ryanodine Receptors [PDF]

Biophysical Journal, 2008
openaire   +1 more source