Results 71 to 80 of about 3,057,586 (215)
L’intégration des TIC dans la séquence pédagogique en espagnol : le concept d’espace langue
ALSIC: Apprentissage des Langues et Systèmes d'Information et de Communication, 1999 How can we help our pupils to take a more active part in their learning? How can we provide the conditions of a valuable "apprenticeship" which will act as an incentive to profitable learning?
Denis Lucchinacci
doaj +1 more source
FEBS Letters, EarlyView.Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley +1 more source
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
, 2013 Comment s'y prendre pour élaborer une séquence d'enseignement ? Peut-on tout prévoir ? Notre mémoire se centre sur le décalage qui existe entre la conception d'une séquence pédagogique et sa réalisation en classe. D'où vient ce décalage ?
Dumax, Jean-Pierre, Schlewer, Violaine
core
Mechanisms of parasite‐mediated disruption of brain vessels
FEBS Letters, EarlyView.Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira +3 more
wiley +1 more source
Corela, 2015 This contribution will analyze rephrasing in a CM2 class during a sequence dealing with the concept of ecosystem. Rephrasing perform specific functions according to their type and when they occur, whether initiated by the teacher and / or students.
Stéphanie Volteau
doaj +1 more source
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
L'enseignement du portugais brésilien à Genève: une séquence didactique adaptée au contexte LCO
Babylonia, 2023 Cette contribution a pour but de discuter de la mise en œuvre d’un dispositif didactique visant l’enseignement et l’apprentissage de la lecture et de la production orale collective d’une histoire dans une classe de portugais brésilien langue d’origine ...
Carla Silva-Hardmeyer +2 more
doaj
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
FEBS Letters, EarlyView.Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman +2 more
wiley +1 more source