Results 61 to 70 of about 3,085,356 (235)
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Quelle unité pour l’argumentation ? La concession, entre cellule et séquence argumentative
SHS Web of Conferences, 2018 La séquence argumentative de Jean-Michel Adam, inspirée du fameux modèle de Toulmin, peine à intégrer en son sein les concessions. Il est proposé ici de donner les contours d’une unité argumentative plus stable et plus flexible, la cellule, qui tiendrait
Herman Thierry
doaj +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
La séquence du génome de la poule et ses applications en sélection
INRAE Productions Animales, 2006 En décembre 2004, soit trois ans seulement après celle de l’homme, la première version de la séquence du génome de la poule a été publiée. Ce travail est le résultat de plus de dix années de recherches en génomique.
A. VIGNAL , B. BESBES
doaj +1 more source
FEBS Letters, EarlyView.Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas +3 more
wiley +1 more source
An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
FEBS Letters, EarlyView.Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source
L’intégration des TIC dans la séquence pédagogique en espagnol : le concept d’espace langue
ALSIC: Apprentissage des Langues et Systèmes d'Information et de Communication, 1999 How can we help our pupils to take a more active part in their learning? How can we provide the conditions of a valuable "apprenticeship" which will act as an incentive to profitable learning?
Denis Lucchinacci
doaj +1 more source
Séquence 1. « En France qui gouverne le mouvement sportif ? »
, 2019 Alain BRAUN,Administrateur de l’UNCU et animateur de la séquence Bonjour à toutes et à tous, bienvenue à la première séquence de notre 30e Université Sportive d’Été.
Braun, Alain
core +1 more source
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source