Results 71 to 80 of about 3,222,582 (225)

Le récit dans l’image : séquence, intrigue et configuration

open access: yesImage & Narrative, 2011
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Raphaël Baroni
doaj  

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

open access: yesFEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt   +8 more
wiley   +1 more source

L’intégration des TIC dans la séquence pédagogique en espagnol : le concept d’espace langue

open access: yesALSIC: Apprentissage des Langues et Systèmes d'Information et de Communication, 1999
How can we help our pupils to take a more active part in their learning? How can we provide the conditions of a valuable "apprenticeship" which will act as an incentive to profitable learning?
Denis Lucchinacci
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

open access: yesFEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang   +2 more
wiley   +1 more source

Séquence ERC : comment améliorer l’utilisation des méthodes de dimensionnement de la compensation écologique  ?

open access: yesVertigO, 2019
Insufficient knowledge, tools and shared methodologies are identified as one of the causes of the weakness of the application in France of the mitigation hierarchy. This includes methods to evaluate the achievement of the No Net Loss Goal (MNNL).
Agnès Mechin, Sylvain Pioch
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

open access: yesFEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

La conception d’une séquence didactique permettant le développement des habiletés prosodiques : recherche-développement

open access: yesCanadian Journal of Applied Linguistics
Notre étude s’intéresse au développement des compétences en lectures des élèves du primaire, plus précisément, celles reliées à la prosodie. Elle visait la conception d’une séquence didactique axée sur l’enseignement explicite de la ponctuation en ...
Meredith Lachance, Anila Fejzo
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

open access: yesFEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Repenser la séquence démocratique. Analyse quantitative et qualitative des innovations gouvernementales en Chine

open access: yesTracés, 2017
Yu Keping’s article invites us to reflect on the specificity of the link between academics and the Chinese government as well as the political and ideological context in which local innovations take place.
Chunyu Shi
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

open access: yesFEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante   +10 more
wiley   +1 more source

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