Results 71 to 80 of about 3,085,356 (235)

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

open access: yesFEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil   +4 more
wiley   +1 more source

Séquence ERC : comment améliorer l’utilisation des méthodes de dimensionnement de la compensation écologique  ?

open access: yesVertigO, 2019
Insufficient knowledge, tools and shared methodologies are identified as one of the causes of the weakness of the application in France of the mitigation hierarchy. This includes methods to evaluate the achievement of the No Net Loss Goal (MNNL).
Agnès Mechin, Sylvain Pioch
doaj   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

open access: yesFEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Le récit dans l’image : séquence, intrigue et configuration

open access: yesImage & Narrative, 2011
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Raphaël Baroni
doaj  

The human gut microbiome across the life course

open access: yesFEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero   +4 more
wiley   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

open access: yesFEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai   +4 more
wiley   +1 more source

Repenser la séquence démocratique. Analyse quantitative et qualitative des innovations gouvernementales en Chine

open access: yesTracés, 2017
Yu Keping’s article invites us to reflect on the specificity of the link between academics and the Chinese government as well as the political and ideological context in which local innovations take place.
Chunyu Shi
doaj   +1 more source

Sortir du plan-séquence collapsologue ?

open access: yes, 2020
International audienceLes réalisateurs de la série L’effondrement, diffusée l’an dernier sur Canal + ont fait le choix filmique du plan-séquence pour nous immerger dans la réalité (provisoirement fictionnelle) d’un écroulement de nos institutions et de ...
Citton, Yves, Rasmi, Jacopo
core  

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

open access: yesFEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

La territorialisation de la séquence ERC : quels enjeux liés au changement d'échelle d'élaboration et d'application de la séquence ERC ?

open access: yes, 2018
La séquence Eviter-Réduire-Compenser vise l’atteinte de la non-perte nette de biodiversité. Toutefois, de nombreuses limites apparaissent lors de l’application de cette séquence. L’une d’entre elles est la prise en compte de la finitude de l’espace.
Ollivier, Camille
core   +1 more source

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