Results 81 to 90 of about 3,057,586 (215)

Apprendre et comprendre l'ordinateur en même temps : l'apprentissage dans l'action en maternelle en utilisant les TICE

open access: yes, 2013
Dans le cadre de notre stage de master 2, nous nous sommes fixé comme objectif d'initier les élèves d'une classe de maternelle à l'utilisation des TICE. L'enjeu était double puisque les élèves devaient comprendre le fonctionnement de l'ordinateur tout en
Chenu, Chrystèle, Vernet, Morgan
core  

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

A Step Forward in the Development of a Molecular Database for African Horse Sick ness Virus

open access: yesRevue d’Elevage et de Médecine Vétérinaire des Pays Tropicaux, 2009
Resumen en inglès, ver archivo ...
K. Bachanek-Bankowska   +3 more
doaj   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

open access: yesFEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva   +10 more
wiley   +1 more source

Comment faire évoluer les conceptions des élèves ? Les températures de changement d'état de l'eau au cycle 3

open access: yes, 2013
Comment faire comprendre aux élèves que l'eau change d'état à des températures constantes et ce indépendamment de la température de l'environnement et de la puissance de chauffage de l'eau ?
Capo Di Fero de Montarsolo, Amélie   +1 more
core  

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Concevoir une séquence d’enseignement-apprentissage de l’adjectif : pièges et difficultés en formation initiale

open access: yesLidil
Our contribution analyses the traces of students undergoing initial teacher training for primary teaching. In writings on the preparation of sequences on the adjective and extracts from their research dissertations, we observe how novice teachers deal ...
Annette Schmehl-Postaï
doaj   +1 more source

Collocations transdisciplinaires : réflexion pour l'enseignement

open access: yes, 2014
International audienceThis is the presentation of the research project FULS about teaching the academic writings phraseology. Reflection revolved around the use of a corpus of scientific writings (Scientext) for assistance in academic writing to non ...
Cavalla, Cristelle
core   +1 more source

PICALM::MLLT10 translocated leukemia

open access: yesFEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen   +7 more
wiley   +1 more source

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