Results 111 to 120 of about 37,527 (267)

Bioinformatics and Expression Profiling of the DHHC-CRD S-Acyltransferases Reveal Their Roles in Growth and Stress Response in Woodland Strawberry (Fragaria vesca)

Plants
Protein S-acyl transferases (PATs) are a family of enzymes that catalyze protein S-acylation, a post-translational lipid modification involved in protein membrane targeting, trafficking, stability, and protein–protein interaction.
Si Gu, Xinghua Nie, Amal George, Kyle Tyler, Yu Xing, Ling Qin, Baoxiu Qi   +6 more
doaj   +1 more source

Greasing the wheels or a spanner in the works?:Regulation of the cardiac sodium pump by palmitoylation [PDF]

, 2018
The ubiquitous sodium/potassium ATPase (Na pump) is the most abundant primary active transporter at the cell surface of multiple cell types, including ventricular myocytes in the heart.
Fiona Plain, Jacqueline Howie, Kakar SS, Krzysztof J. Wypijewski, Lindsay B. Tulloch, Mullins LJ., Niall J. Fraser, Pitts BJ, Presti CF, Presti CF, William Fuller   +10 more
core   +3 more sources

Multifunctional Reagents for Quantitative Proteome-Wide Analysis of Protein Modification in Human Cells and Dynamic Profiling of Protein Lipidation During Vertebrate Development [PDF]

, 2015
Novel multifunctional reagents were applied in combination with a lipid probe for affinity enrichment of myristoylated proteins and direct detection of lipid-modified tryptic peptides by mass spectrometry.
Boersema, Cox, Dieterich, Hannoush, Heal, Lin, Lin, Speers, Tate, Thinon, Vizcaíno, Wilson, Wright, Wright, Zhang, Zheng   +15 more
core   +2 more sources

Computational design of syntheses leading to compound libraries or isotopically labelled targets [PDF]

, 2019
Although computer programs for retrosynthetic planning have shown improved and in some cases quite satisfactory performance in designing routes leading to specific, individual targets, no algorithms capable of planning syntheses of entire target ...
Abu-El-Haj, Al-Taher, Allen, Anzenbacher, Aubry, Badowski, Beker, Berglund, Bracher, Brenna, Brown, Bøgevig, Chan, Coley, Corey, Corey, Cortez, Costello, Cushing, Dixon, Dörwald, Ellman, Emami, Faller, Fialkowski, Gao, Gelernter, Graves, Grzybowski, Grzybowski, Hanessian, He, Hendrickson, Hyland, Jiang, Johnston, Jones, Jordan, Kayala, Kim, Klucznik, Kohara, Kowalik, Lin, Liu, Liu, Liu, Molga, Mori, Mutlib, Nebot, Nottingham, Ohkuma, Pablo, Planas, Ravitz, Rej, Schlosser, Schmidt, Schwartz, Segler, Shinde, Silver, Skoraczyński, Stivala, Stöckigt, Suceveanu, Sutskever, Syed, Szymkuć, Tang, Tsuritani, Ugi, Unkefer, Verspui, Wang, Wei, Woudneh, Wójcikowski, Zhang, Zhao   +80 more
core   +1 more source

Going Round in Circles with N→S Acyl Transfer [PDF]

Synlett, 2017
It is not highly sophisticated, yet the N→S acyl transfer reaction of a native peptide sequence potentially fills an important technology gap. While several routes to synthetic peptide thioesters exist, only one is routinely applicable for biologically derived samples. Using the naturally occurring amino acid cysteine as the sole activator for N→S acyl
openaire   +2 more sources

Protocol to identify S-acylated proteins in hippocampal neurons using ω-alkynyl fatty acid analogs and click chemistry

STAR Protocols
Summary: S-acylation, commonly palmitoylation, is the addition of fatty acids to cysteines to regulate protein localization and function. S-acylation detection has been hampered by limited sensitivity and selectivity in low-protein, costly samples like ...
Charlotte A. Townsend, Andrey A. Petropavlovskiy, Jordan A. Kogut, Alysha M. Church, Shaun S. Sanders   +4 more
doaj   +1 more source

Chemical proteomics: a powerful tool for exploring protein lipidation [PDF]

, 2013
The study of post-translational modifications such as protein lipidation is a non-trivial challenge of the post-genomic era. In recent years the field of chemical proteomics has greatly advanced our ability to identify and quantify protein lipidation. In
Serwa, RA, Storck, EM, Tate, EW
core   +1 more source

Chemoproteomics reveals Toll-like receptor fatty acylation [PDF]

, 2014
Partial funding for Open Access provided by The Ohio State University Open Access Fund.Background: Palmitoylation is a 16-carbon lipid post-translational modification that increases protein hydrophobicity.
A Bafica, AF Roth, AI Su, AI Su, BA Merrick, Balyn W Zaro, BH Zheng, BR Martin, BR Martin, C Aicart-Ramos, C Ivaldi, C Salaun, C Wu, CB Lopez, CB Lopez, CT Tom, D Davda, D Rotin, E Latz, E Lorenz, F Sandor, G Charron, G Charron, GJ Freeman, H Kato, HC Hang, Howard C Hang, J Charollais, J Greaves, J Greaves, J Ren, Jacob S Yount, James L Chen, JC Hach, JL Hernandez, Joanne Turner, Jocelyn C Hach, JP Wilson, JS Yount, JS Yount, JS Yount, JS Yount, JS Yount, JS Yount, JS Yount, JS Yount, KJ Brandt, L Dowal, Larry S Schlesinger, M Fukata, M Muzio, M Scheffner, M Triantafilou, M Yamamoto, MA Imro, Matthew R Pratt, ME Linder, Murugesan VS Rajaram, Nicholas M Chesarino, NT Thuong, O Takeuchi, P Hollsberg, P Mill, R Barbalat, R Kang, R Tsutsumi, RM Steinman, RN Hannoush, S Blaskovic, S Borrello, S Kupzig, SC Henry, T Kawai, T Kawai, TR Hawn, Y Bulut, Y Fukata, Y Li, Y Webb, YY Yang, Z Jiang   +80 more
core   +2 more sources

Unlocking fruit dimensions: Quantification of functional traits driving plant–frugivore interactions

Applications in Plant Sciences, EarlyView.
Abstract Fleshy fruits attract animals to ingest fruit, swallow the seeds, and release them in the landscape, thus facilitating seed dispersal and plant regeneration. Attraction of animal dispersers is achieved via attractants such as color or scent, and rewards like sugars, lipids, and micronutrients.
Linh M. N. Nguyen, Evangelia Linda Chronopoulou, Gabriela A. S. Escaliante, Kim Valenta, Omer Nevo   +4 more
wiley   +1 more source

Fatty acid mobilization from adipose tissue is mediated by CD36 posttranslational modifications and intracellular trafficking

JCI Insight, 2021
The mechanism controlling long-chain fatty acid (LCFA) mobilization from adipose tissue is not well understood. Here, we investigated how the LCFA transporter CD36 regulates this process.
Alexes C. Daquinag, Zhanguo Gao, Cale Fussell, Linnet Immaraj, Renata Pasqualini, Wadih Arap, Askar M. Akimzhanov, Maria Febbraio, Mikhail G. Kolonin   +8 more
doaj   +1 more source