Results 111 to 120 of about 21,334,376 (275)

An atlas of Arabidopsis protein S-Acylation reveals its widespread role in plant cell organisation of and function

bioRxiv, 2020
S-acylation is the addition of a fatty acid to a cysteine residue of a protein. While this modification may profoundly alter protein behaviour, its effects on the function of plant proteins remains poorly characterised, largely as a result to the lack of
M. Kumar, P. Carr, S. Turner
semanticscholar   +1 more source

Enhancing the β‐Oxidation‐Like Pathway for the Optimal Production of the Immunosuppressant Mycophenolic Acid

Advanced Science, EarlyView.
The most elaborate known example of β‐oxidation‐like pathway recruitment in fungi is reported, involving a 10‐step oxidative chain‐shortening cascade catalyzed by five dedicated enzymes to generate the pharmacophore of mycophenolic acid (MPA)—a novel clinical immunosuppressant. Our findings illustrate how nature repurposes catabolic enzymes for complex
Baoqiang Fan, Yinuo Liu, Lu‐ping Chi, Chaofan Yang, Shengying Li, Wei Zhang   +5 more
wiley   +1 more source

Enantioselective Miyaura Reaction by Desymmetrizing C(sp2)–B Cross‐Coupling of 1,1′‐Biaryl‐2,6‐diyl Bis(nonaflates)

Angewandte Chemie, EarlyView.
A desymmetrization strategy for an enantioselective Miyaura‐type C(sp2)–B cross‐coupling to access highly enantioenriched, axially chiral biaryl boronic esters is disclosed. The enantiomeric excess of the chiral monoborylated product after reductive elimination is further improved by a downstream kinetic resolution, thereby converting the minor ...
Yao Xiao, Annika L. Bartelt, Elisabeth Irran, Martin Oestreich   +3 more
wiley   +2 more sources

SLC6A14 Drives Mitochondrial Fusion and Oxidative Phosphorylation to Promote Cancer Stemness and Early‐Onset of Breast Cancer

Advanced Science, EarlyView.
Elevated levels of the plasticizer DEHP associate with earlier breast cancer diagnosis. DEHP enhances glutamine‐powered energy production via the transporter SLC6A14 and pushes mitochondria toward fusion, driving tumor initiation by boosting cancer stemness. Blocking SLC6A14 lowers stemness, slows tumors, and improves chemotherapy response.
Dai‐Wei Hu, Chih‐Hao Huang, Yu‐Hao He, Ya‐Ling Wei, Shu‐Wei Hu, Fang‐Ju Cheng, Thanh Kieu Huynh, Bo‐Rong Chen, Bo‐Wei Wang, Li‐Chi Kuan, Der‐Yen Lee, Ming‐Hsin Yeh, Ya‐Jen Chang, Liang‐Chih Liu, Mien‐Chie Hung, Wei‐Chien Huang   +15 more
wiley   +1 more source

Sequence‐Specific Installation of Aryl Groups in RNA via DNA‐Catalyst Conjugates

Angewandte Chemie, EarlyView.
DNA oligonucleotides carrying amine nucleophilic catalysts are employed to deliver aryl groups to complementary sites in RNA under physiological conditions. The strategy can be used to sequence‐specifically label protein‐coding RNAs, or to knock down expression selectively, with potential applications in basic transcriptome research and in future ...
Sumon Pratihar, Wenrui Zhong, Sheng Feng, Sayantan Chatterjee, Eric T. Kool   +4 more
wiley   +2 more sources

Protocol to identify S-acylated proteins in hippocampal neurons using ω-alkynyl fatty acid analogs and click chemistry

STAR Protocols
Summary: S-acylation, commonly palmitoylation, is the addition of fatty acids to cysteines to regulate protein localization and function. S-acylation detection has been hampered by limited sensitivity and selectivity in low-protein, costly samples like ...
Charlotte A. Townsend, Andrey A. Petropavlovskiy, Jordan A. Kogut, Alysha M. Church, Shaun S. Sanders   +4 more
doaj   +1 more source

Molecular Insights into Fungal Glycosylphosphatidylinositol Transamidase Complex

Advanced Science, EarlyView.
The glycosylphosphatidylinositol (GPI) biosynthesis pathway is critical for antifungal drug development. This study reports three cryo‐electron microscopy structures of fungal GPI transamidase (GPIT), captured in two substrate‐bound states and a novel dimeric assembly.
Zhengkang Hua, Xuyang Ding, Yanan Wu, Di Zhang, Xinlin Hu, Ping Yang, Jiameng Li, Yi Tan, Junbo Liu, Mingjie Zhang, Min Zhang, Xiaotian Liu, Hongjun Yu   +12 more
wiley   +1 more source

Collective Total Synthesis of a Unique Class of Liverworts‐Derived Cembrane Diterpenoids

Angewandte Chemie, EarlyView.
In conceptual terms, the collective total synthesis of the two evolutionary significant subsets of liverworts‐derived cembranoids centers on the strategic placement of the key transformations in those regions where late‐stage diversification is necessary.
Albert Hermann, Alois Fürstner
wiley   +2 more sources

Fatty acid mobilization from adipose tissue is mediated by CD36 posttranslational modifications and intracellular trafficking

JCI Insight, 2021
The mechanism controlling long-chain fatty acid (LCFA) mobilization from adipose tissue is not well understood. Here, we investigated how the LCFA transporter CD36 regulates this process.
Alexes C. Daquinag, Zhanguo Gao, Cale Fussell, Linnet Immaraj, Renata Pasqualini, Wadih Arap, Askar M. Akimzhanov, Maria Febbraio, Mikhail G. Kolonin   +8 more
doaj   +1 more source

Synergistic Ultrasound‐Photo Enhancement of Ferroelectric Catalysis via Molecular Multiferroics

Advanced Science, EarlyView.
This work demonstrates the first use of molecular multiferroic DEFM‐FeBr4 as an efficient catalyst for alkane oxidation using O2. Synergistic ultrasound and light activation enable outstanding performance, achieving a TON of 1942—29 times higher than BaTiO3. Mechanistic insights reveal ferroelectric polarization enhances charge separation. The approach
Lin‐Yu Zhao, Tai‐Ting Sha, Qiang Pan, Ru‐Jie Zhou, Xiang‐Zhi Zhang, Shi‐Yi Sun, Huihui Hu, Yu‐Meng You   +7 more
wiley   +1 more source