Results 141 to 150 of about 37,527 (267)

Investigating S-acylation in the metabolic dysfunction of the T2D heart [PDF]

Cardiovascular disease is the leading cause of mortality in type 2 diabetes (T2D) patients. Metabolic dysfunction is apparent within the T2D heart, presenting with an increased reliance on lipid metabolism and decreased glucose metabolism.
Dennis, Kaitlyn MJH
core   +2 more sources

Understanding protein–flavor interactions: Factors, characterization techniques, and the effect of processing

Food Biomacromolecules, EarlyView.
Abstract The perception of flavor in a food system depends on its release from the protein matrix. Apart from hydrogen bonding, hydrophobic interactions and van der Waal's forces, the formation of covalent adducts between the flavor and protein highly impacts the release of flavor from the protein matrix.
Arshita Verma, Somnath Basak, Rekha S. Singhal   +2 more
wiley   +1 more source

Screening anticancer peptides performance in organotypic prostate tumor‐stroma 3D models

International Journal of Cancer, EarlyView.
What's New? Peptide‐based drugs have emerged as promising anticancer therapies for their potential to disrupt protein–protein interactions. In this study, the authors developed a physiomimetic human 3D prostate cancer spheroid model to assess the efficacy of the CAVPENET peptide in inhibiting tumor growth. Upon incubation with CAVPENET, prostate cancer
Bárbara Matos, Maria V. Monteiro, Matilde R. Lagarto, John Howl, Carmen Jerónimo, Vítor M. Gaspar, João F. Mano, Margarida Fardilha   +7 more
wiley   +1 more source

Probing Metal Tip‐Induced Bond Weakening of a Reactive Alkyne Center Aligned via a Rigid Triphenylmethane‐Based Tripod on Au(111) by TERS and DFT

Journal of Raman Spectroscopy, EarlyView.
We investigate tip‐induced bond weakening of a single alkyne center immobilized and aligned upright on Au(111) using a rigid triphenylmethane‐based tripod. By varying the tip–molecule distance, we observe shifts in the ≡C–H and –C≡C– vibrational bands via ultrahigh vacuum low‐temperature tip‐enhanced Raman scattering (TERS).
Gang Li, Simon Mennicken, Lu‐Yao Zhu, Sadaf Ehtesabi, Till Reichenauer, Stephan Kupfer, Daniel Schäfer, Saber Mehrparvar, Gebhard Haberhauer, Yao Zhang, Stefanie Gräfe, Sebastian Schlücker, Zhen‐Chao Dong   +12 more
wiley   +1 more source

Mechanophoric 3‐Arm Star Functional Block Copolymer Based on Rhodamine Derivative

Macromolecular Materials and Engineering, EarlyView.
Mechanoresponsive rhodamine containing linear and star block and random copolymers were synthesized and characterized. All materials transitioned into a “switch‐on” state in the film form, but only the star block copolymer architecture exhibited a complete and precise peak shift upon stretching, providing new insights into the mechanochemical ...
Swadhin Chakraborty, Soumik Chatterjee, N. D. Pradeep Singh, Albena Lederer, Martin Geisler, Qiong Li, Mahmoud Al‐Hussein, Brigitte Voit, Nikhil K. Singha   +8 more
wiley   +1 more source

Poly(sarcosine) Lipid Synthesis From CO2‐Based Sarcosine‐N‐Carboxyanhydride

Macromolecular Rapid Communications, EarlyView.
In this work, we optimize and scale‐up a CO2‐based synthesis of sarcosine‐N‐carboxyanhydride (Sar‐NCA) to the gram scale. The low toxicity and simplicity of the approach make it an attractive alternative to current toxic phosgene‐based approaches. The CO2‐based Sar‐NCA has sufficient purity for controlled polymerization.
Florian T. Kaps, Leon Quellmalz, Annika D. S. Richardson, Anna‐Lena Ziegler, Sarah Moreau, Susanne K. Wiedmer, Timo Repo, Robert Luxenhofer   +7 more
wiley   +1 more source

N‐myristoylation and S‐acylation are common modifications of Ca²⁺‐regulated Arabidopsis kinases and are required for activation of the SLAC1 anion channel [PDF]

, 2018
Shunya Saito, Shin Hamamoto, Koko Moriya, Aiko Matsuura, Yoko Sato, Jun Muto, Hiroto Noguchi, Seiji Yamauchi, Yuzuru Tozawa, Minoru Ueda, Kenji Hashimoto, Philipp Köster, Qiuyan Dong, Katrin Held, Jörg Kudla, Toshihiko Utsumi, Nobuyuki Uozumi   +16 more
openalex   +1 more source

Rapid Epoxy Polymerization Induced by Aliphatic Cyclic Tertiary Amines: The Roles of Nucleophilicity and Leaving Ability

Macromolecular Rapid Communications, EarlyView.
Quinuclidine, as a tertiary amine, can rapidly polymerize epoxy groups. We investigated the relationship between amine properties and polymerization behavior by monitoring the reactions of various tertiary amines with epoxy groups. The results indicate that quinuclidine, the most nucleophilic amine examined, promotes epoxy polymerization.
Yukai Ito, Daisuke Aoki, Koji Arimitsu
wiley   +1 more source

Analytical Approaches to Address Challenges in the Analysis of Cannabinoids in Vascular Matrices Using Mass Spectrometry

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Phytocannabinoids are bioactive metabolites derived from the Cannabis sativa plant. They have garnered attention due to their recreational uses and therapeutic potential. Although various analytical strategies have been employed for their analysis, mass spectrometry (MS) coupled to chromatographic separation is superior due to its sensitivity ...
Radwa Mahmoud, Robert B. Laprairie, Anas El‐Aneed   +2 more
wiley   +1 more source

FeCl3‐Catalyzed Synthesis of Ynones from Silylated Alkynes and Acetic Anhydride

ChemistryOpen, EarlyView.
The synthesis of alkynones from silylated alkynes and acid chlorides, first reported by Birkhofer in 1963, remains a valuable transformation. However, its reliance on stoichiometric AlCl3 and corrosive reagents raises environmental and practical concerns. To address this, a greener protocol using catalytic FeCl3 and acetic anhydride is developed.
Paul Charki, Urs Gellrich, Daniel S. Müller   +2 more
wiley   +1 more source