Results 11 to 20 of about 36,153 (123)

Dynamics of CLIMP-63 S-acylation control ER morphology [PDF]

Nature Communications, 2023
A key player in the formation of endoplasmic reticulum sheets is CLIMP-63, but mechanistic details remained elusive. Here authors combined cellular experiments and mathematical modelling to show that S-acylation of CLIMP-63 regulates its function by ...
Patrick A. Sandoz, Robin A. Denhardt-Eriksson, Laurence Abrami, Luciano A. Abriata, Gard Spreemann, Catherine Maclachlan, Sylvia Ho, Béatrice Kunz, Kathryn Hess, Graham Knott, Francisco S. Mesquita, Vassily Hatzimanikatis, F. Gisou van der Goot   +12 more
doaj   +4 more sources

Efficient S-Acylation of Thiourea [PDF]

SynOpen, 2018
Efficient S-acylation of thiourea using a variety of acid chlorides is reported. Structurally diverse aryl and alkyl substrates are compatible with this methodology.
David J. Jones, Uday B. Rao Khandavilli, Eileen M. O’Leary, Simon E. Lawrence, Timothy P. O’Sullivan   +4 more
doaj   +3 more sources

In vitro reconstitution of substrate S-acylation by the zDHHC family of protein acyltransferases [PDF]

Open Biology, 2022
Protein S-acylation, more commonly known as protein palmitoylation, is a biological process defined by the covalent attachment of long chain fatty acids onto cysteine residues of a protein, effectively altering the local hydrophobicity and influencing ...
R. Elliot Murphy, Anirban Banerjee
doaj   +2 more sources

Improvement of plant resistance to geminiviruses via protein de-S-acylation [PDF]

Stress Biology
Geminiviruses are an important group of viruses that infect a variety of plants and result in heavy agricultural losses worldwide. The homologs of C4 (or L4) in monopartite geminiviruses and AC4 (or AL4) in bipartite geminiviruses are critical viral ...
Yawen Zhao, Zhenggang Li, Zhiying Wang, Liting Huang, Gongda Li, Xiaoshi Liu, Meiqi Yuan, Wei Huang, Lishan Ling, Chengwei Yang, Zifu He, Jianbin Lai   +11 more
doaj   +2 more sources

The landscape of renal protein S-acylation in mice with lipid-induced nephrotoxicity [PDF]

Scientific Reports
Excess fat intake is associated with kidney toxicity and dysfunction. Because fatty acids can also be reversibly attached onto cysteine residues and modulate the function of several membrane-bound proteins, we studied the effect of high-fat diet (HFD) on
Fangrui Xiu, Zhibo Gai, Peter Gehrig, Witold E. Wolski, Museer A. Lone, Michele Visentin   +5 more
doaj   +2 more sources

S-acylation of a non-secreted peptide controls plant immunity via secreted-peptide signal activation [PDF]

EMBO Reports
Small peptides modulate multiple processes in plant cells, but their regulation by post-translational modification remains unclear. ROT4 (ROTUNDIFOLIA4) belongs to a family of Arabidopsis non-secreted small peptides, but knowledge on its molecular ...
Wenliang Li, Tushu Ye, Weixian Ye, Jieyi Liang, Wen Wang, Danlu Han, Xiaoshi Liu, Liting Huang, Youwei Ouyang, Jianwei Liao, Tongsheng Chen, Chengwei Yang, Jianbin Lai   +12 more
doaj   +2 more sources

Global, site-specific analysis of neuronal protein S-acylation [PDF]

Scientific Reports, 2017
Protein S-acylation (palmitoylation) is a reversible lipid modification that is an important regulator of dynamic membrane-protein interactions. Proteomic approaches have uncovered many putative palmitoylated proteins however, methods for comprehensive ...
Mark O. Collins, Keith T. Woodley, Jyoti S. Choudhary   +2 more
doaj   +6 more sources

Refining S-acylation: Structure, regulation, dynamics, and therapeutic implications. [PDF]

J Cell Biol, 2023
With a limited number of genes, cells achieve remarkable diversity. This is to a large extent achieved by chemical posttranslational modifications of proteins. Amongst these are the lipid modifications that have the unique ability to confer hydrophobicity.
Anwar MU, van der Goot FG.
europepmc   +3 more sources

Fat traffic control: S-acylation in axonal transport. [PDF]

Mol Pharmacol
Neuronal axons serve as a conduit for the coordinated transport of essential molecular cargo between structurally and functionally distinct subcellular compartments via axonal molecular machinery. Long-distance, efficient axonal transport of membrane-bound organelles enables signal transduction and neuronal homeostasis.
Doerksen AH, Herath NN, Sanders SS.
europepmc   +3 more sources

Mechanisms and functions of protein S-acylation. [PDF]

Nat Rev Mol Cell Biol
Over the past two decades, protein S-acylation (often referred to as S-palmitoylation) has emerged as an important regulator of vital signalling pathways. S-Acylation is a reversible post-translational modification that involves the attachment of a fatty acid to a protein.
S Mesquita F, Abrami L, Linder ME, Bamji SX, Dickinson BC, van der Goot FG.   +5 more
europepmc   +3 more sources