Results 11 to 20 of about 37,527 (267)
Regulation of Dynamic Protein S-Acylation [PDF]
Frontiers in Molecular Biosciences, 2021 Protein S-acylation is the reversible addition of fatty acids to the cysteine residues of target proteins. It regulates multiple aspects of protein function, including the localization to membranes, intracellular trafficking, protein interactions ...
Jessica J. Chen +2 more
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Regulation of T cell function by protein S-acylation [PDF]
Frontiers in Physiology, 2022 S-acylation, the reversible lipidation of free cysteine residues with long-chain fatty acids, is a highly dynamic post-translational protein modification that has recently emerged as an important regulator of the T cell function. The reversible nature of
Savannah J. West +4 more
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Regulatory effects of protein S-acylation on insulin secretion and insulin action [PDF]
Open Biology, 2021 Post-translational modifications (PTMs) such as phosphorylation and ubiquitination are well-studied events with a recognized importance in all aspects of cellular function.
Luke H. Chamberlain +2 more
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Efficient S-Acylation of Thiourea [PDF]
SynOpen, 2018 Efficient S-acylation of thiourea using a variety of acid chlorides is reported. Structurally diverse aryl and alkyl substrates are compatible with this methodology.
David J. Jones +4 more
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Improvement of plant resistance to geminiviruses via protein de-S-acylation [PDF]
Stress BiologyGeminiviruses are an important group of viruses that infect a variety of plants and result in heavy agricultural losses worldwide. The homologs of C4 (or L4) in monopartite geminiviruses and AC4 (or AL4) in bipartite geminiviruses are critical viral ...
Yawen Zhao +11 more
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Grain setting defect1 (GSD1) function in rice depends on S-acylation and interacts with actin 1 (OsACT1) at its C-terminal [PDF]
Frontiers in Plant Science, 2015 Grain setting defect1 (GSD1), a plant-specific remorin protein specifically localized at the plasma membrane and plasmodesmata of phloem companion cells, affects grain setting in rice through regulating the transport of photoassimilates.
Jinshan eGui +3 more
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Oleate activates PLD2 lipase and GEF activity by modulating membrane microdomain dynamics via S-acylation [PDF]
Journal of Lipid ResearchPhospholipase D2 (PLD2) plays critical roles in cellular signaling, membrane dynamics, and cancer progression. Oleate (OA) has been shown to activate PLD2 and promote triple-negative breast cancer (TNBC) cell migration, but the underlying molecular ...
Zhiqiang Guo +2 more
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S‐acylation of Ca2+ transport proteins in cancer [PDF]
Chronic Diseases and Translational MedicineAlterations in cellular calcium (Ca2+) signals have been causally associated with the development and progression of human cancers. Cellular Ca2+ signals are generated by channels, pumps, and exchangers that move Ca2+ ions across membranes and are ...
Sana Kouba, Nicolas Demaurex
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Global, site-specific analysis of neuronal protein S-acylation [PDF]
Scientific Reports, 2017 Protein S-acylation (palmitoylation) is a reversible lipid modification that is an important regulator of dynamic membrane-protein interactions. Proteomic approaches have uncovered many putative palmitoylated proteins however, methods for comprehensive ...
Mark O. Collins +2 more
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Dynamics of CLIMP-63 S-acylation control ER morphology [PDF]
Nature Communications, 2023 A key player in the formation of endoplasmic reticulum sheets is CLIMP-63, but mechanistic details remained elusive. Here authors combined cellular experiments and mathematical modelling to show that S-acylation of CLIMP-63 regulates its function by ...
Patrick A. Sandoz +12 more
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