Results 41 to 50 of about 36,153 (123)
Ion channel regulation by protein S-acylation [PDF]
Journal of General Physiology, 2014 Protein S-acylation, the reversible covalent fatty-acid modification of cysteine residues, has emerged as a dynamic posttranslational modification (PTM) that controls the diversity, life cycle, and physiological function of numerous ligand- and voltage-gated ion channels.
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Dynamic acylome reveals metabolite driven modifications in Syntrophomonas wolfei
Frontiers in Microbiology, 2022 Syntrophomonas wolfei is an anaerobic syntrophic microbe that degrades short-chain fatty acids to acetate, hydrogen, and/or formate. This thermodynamically unfavorable process proceeds through a series of reactive acyl-Coenzyme A species (RACS). In other
Janine Y. Fu +15 more
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Metabolically controlled histone H4K5 acylation/acetylation ratio drives BRD4 genomic distribution
Cell Reports, 2021 Summary: In addition to acetylation, histones are modified by a series of competing longer-chain acylations. Most of these acylation marks are enriched and co-exist with acetylation on active gene regulatory elements.
Mengqing Gao +23 more
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Marine Drugs, 2021 Chitosan nanofiber membranes are recognized as functional antimicrobial materials, as they can effectively provide a barrier that guides tissue growth and supports healing. Methods to stabilize nanofibers in aqueous solutions include acylation with fatty
Carlos Montez Wells +8 more
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Polyglutamine Tract Expansion Increases S-Nitrosylation of Huntingtin and Ataxin-1. [PDF]
PLoS ONE, 2016 Expansion of the polyglutamine (polyQ) tract in the huntingtin (Htt) protein causes Huntington's disease (HD), a fatal inherited movement disorder linked to neurodegeneration in the striatum and cortex.
Chun-Lun Ni +8 more
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Stearic acid blunts growth-factor signaling via oleoylation of GNAI proteins
Nature Communications, 2021 S-acylation is the post-translational covalent attachment of fatty acids (FA) onto cysteines. Nuskova et al. find that exposure of cells to different FAs affects which FA is used to S-acylate GNAI proteins, thereby altering GNAI function and EGFR pathway
Hana Nůsková +8 more
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Molecules, 2022 Amides, anhydrides, esters, and thioesters of 2H-azirine-2-carboxylic acids were prepared by a rapid procedure at room temperature involving FeCl2-catalyzed isomerization of 5-chloroisoxazoles to 2H-azirine-2-carbonyl chlorides, followed by reaction with
Anastasiya V. Agafonova +2 more
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Detection of S-Acylated CD95 by Acyl-Biotin Exchange [PDF]
, 2017 S-acylation is the covalent addition of a fatty acid, most generally palmitate onto cysteine residues of proteins through a labile thioester linkage. The death receptor CD95 is S-palmitoylated and this post-translational modification plays a crucial role on CD95 organization in cellular membranes and thus on CD95-mediated signaling.
Rossin, Aurélie, Hueber, Anne-Odile
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Acylation – A New Means to Control Traffic Through the Golgi
Frontiers in Cell and Developmental Biology, 2019 The Golgi is well known to act as center for modification and sorting of proteins for secretion and delivery to other organelles. A key sorting step occurs at the trans-Golgi network and is mediated by protein adapters. However, recent data indicate that
Andreas M. Ernst +3 more
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Transition-metal-free trifluoromethylthiolation–acylation of arynes by insertion into the C–S bonds
Green Synthesis and Catalysis, 2021 An efficient procedure to access to ortho-SCF3 substituted benzophenones from arynes and trifluoromethylthioesters has been developed under transition-metal free conditions. This difunctionalization process involves the first insertion of arynes into the
Chengyao Kimmy Cao +2 more
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