Results 41 to 50 of about 37,527 (267)

Development of a novel high-throughput screen for the identification of new inhibitors of protein S-acylation. [PDF]

J Biol Chem, 2022
Salaun C, Takizawa H, Galindo A, Munro KR, McLellan J, Sugimoto I, Okino T, Tomkinson NCO, Chamberlain LH.   +8 more
europepmc   +3 more sources

Progress toward Understanding Protein S-acylation: Prospective in Plants [PDF]

Frontiers in Plant Science, 2017
S-acylation, also known as S-palmitoylation or palmitoylation, is a reversible post-translational lipid modification in which long chain fatty acid, usually the 16-carbon palmitate, covalently attaches to a cysteine residue(s) throughout the protein via a thioester bond.
Yaxiao Li, Baoxiu Qi
openalex   +4 more sources

Protein S-acylation: Pathological mechanisms and novel therapeutic targets for diabetic complications. [PDF]

Chin Herb Med
Liu R, Xu N, Song X, Li Y, Bu J, Su R, Guo H, Jiang C, Zhuang P, Zhang Y, Yin Q.   +10 more
europepmc   +2 more sources

Fat traffic control: S-acylation in axonal transport. [PDF]

Mol Pharmacol
Neuronal axons serve as a conduit for the coordinated transport of essential molecular cargo between structurally and functionally distinct subcellular compartments via axonal molecular machinery. Long-distance, efficient axonal transport of membrane-bound organelles enables signal transduction and neuronal homeostasis.
Doerksen AH, Herath NN, Sanders SS.
europepmc   +3 more sources

Deciphering protein long-chain <i>S</i>-acylation using mass spectrometry proteomics strategies. [PDF]

RSC Chem Biol
Nederstigt AE, Sardana S, Baggelaar MP.
europepmc   +3 more sources

Regulation of Orai1/STIM1 Function by S-Acylation [PDF]

Biophysical Journal, 2020
Savannah J. West, Qiaochu Wang, Michael X. Zhu, Askar M. Akimzhanov, Darren Boehning   +4 more
openalex   +2 more sources

Mechanisms and functions of protein S-acylation. [PDF]

Nat Rev Mol Cell Biol
Over the past two decades, protein S-acylation (often referred to as S-palmitoylation) has emerged as an important regulator of vital signalling pathways. S-Acylation is a reversible post-translational modification that involves the attachment of a fatty acid to a protein.
S Mesquita F, Abrami L, Linder ME, Bamji SX, Dickinson BC, van der Goot FG.   +5 more
europepmc   +3 more sources

Dynamic Protein S-Acylation in Plants [PDF]

International Journal of Molecular Sciences, 2019
Lipid modification is an important post-translational modification. S-acylation is unique among lipid modifications, as it is reversible and has thus attracted much attention. We summarize some proteins that have been shown experimentally to be S-acylated in plants. Two of these S-acylated proteins have been matched to the S-acyl transferase.
Lihua Zheng, Peng Liu, Qianwen Liu, Tao Wang, Jiangli Dong   +4 more
openaire   +2 more sources

Salicylic acid attenuates brassinosteroid signaling via protein de-S-acylation. [PDF]

EMBO J, 2023
AbstractBrassinosteroids (BRs) are important plant hormones involved in many aspects of development. Here, we show that BRASSINOSTEROID SIGNALING KINASEs (BSKs), key components of the BR pathway, are precisely controlled via de‐S‐acylation mediated by the defense hormone salicylic acid (SA). Most Arabidopsis BSK members are substrates of S‐acylation, a
Liu X, Chen Z, Huang L, Ouyang Y, Wang Z, Wu S, Ye W, Yu B, Zhang Y, Yang C, Lai J.   +10 more
europepmc   +3 more sources

S-acylation by ZDHHC20 targets ORAI1 channels to lipid rafts for efficient Ca2+ signaling by Jurkat T cell receptors at the immune synapse

eLife, 2021
Efficient immune responses require Ca2+ fluxes across ORAI1 channels during engagement of T cell receptors (TCR) at the immune synapse (IS) between T cells and antigen presenting cells. Here, we show that ZDHHC20-mediated S-acylation of the ORAI1 channel
Amado Carreras-Sureda, Laurence Abrami, Kim Ji-Hee, Wen-An Wang, Christopher Henry, Maud Frieden, Monica Didier, F Gisou van der Goot, Nicolas Demaurex   +8 more
doaj   +1 more source