Results 71 to 80 of about 37,527 (267)
Journal of Extracellular Vesicles, 2020 Extracellular vesicles (EVs) are membrane-enclosed particles that play an important role in cancer progression and have emerged as a promising source of circulating biomarkers. Protein S-acylation, frequently called palmitoylation, has been proposed as a
Javier Mariscal +10 more
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The C-terminal domain of zDHHC2 contains distinct sorting signals that regulate intracellular localisation in neurons and neuroendocrine cells [PDF]
, 2017 The S-acyltransferase zDHHC2 mediates dynamic S-acylation of PSD95 and AKAP79/150, which impacts synaptic targeting of AMPA receptors. zDHHC2 is responsive to synaptic activity and catalyses the increased S-acylation of PSD95 that occurs following action
Bushell, Trevor J. +4 more
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Studies on the acylation of 4-(2-aminoethylthio)-7-nitrobenzofurazan: the role of bases in promoting the formation of fluorescent S-acyl derivatives through S–N Smiles rearrangement [PDF]
, 2012 The acylation of 4-(2-aminoethylthio)-7-nitrobenzofurazan has been investigated. Depending on the use of the base, a competitive Smiles rearrangement occurs during the acylation step leading to the formation of N-acyl and/or fluorescent S-acyl ...
Ah-Kow +27 more
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Ion channel regulation by protein S-acylation [PDF]
Journal of General Physiology, 2014 Protein S-acylation, the reversible covalent fatty-acid modification of cysteine residues, has emerged as a dynamic posttranslational modification (PTM) that controls the diversity, life cycle, and physiological function of numerous ligand- and voltage-gated ion channels.
openaire +2 more sources
Dynamic acylome reveals metabolite driven modifications in Syntrophomonas wolfei
Frontiers in Microbiology, 2022 Syntrophomonas wolfei is an anaerobic syntrophic microbe that degrades short-chain fatty acids to acetate, hydrogen, and/or formate. This thermodynamically unfavorable process proceeds through a series of reactive acyl-Coenzyme A species (RACS). In other
Janine Y. Fu +15 more
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The zDHHC family of S-acyltransferases [PDF]
, 2015 The discovery of the zDHHC family of S-acyltransferase enzymes has been one of the major breakthroughs in the S-acylation field. Now, more than a decade since their discovery, major questions centre on profiling the substrates of individual zDHHC enzymes
Chamberlain, Luke H. +7 more
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Metabolically controlled histone H4K5 acylation/acetylation ratio drives BRD4 genomic distribution
Cell Reports, 2021 Summary: In addition to acetylation, histones are modified by a series of competing longer-chain acylations. Most of these acylation marks are enriched and co-exist with acetylation on active gene regulatory elements.
Mengqing Gao +23 more
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Association of influenza virus proteins with membrane rafts [PDF]
, 2011 Assembly and budding of influenza virus proceeds in the viral budozone, a domain in the plasma membrane with characteristics of cholesterol /sphingolipid-rich membrane rafts. The viral transmembrane glycoproteins hemagglutinin (HA) and neuraminidase (NA)
Thaa, Bastian, Veit, Michael
core +5 more sources
Angewandte Chemie, EarlyView.Created in BioRender. Bohg, C. (2026) https://BioRender.Com/ vi9hi4f. Rhomboid proteases are a mechanistically unique and evolutionarily conserved protein family. Despite their pharmacological relevance, the development of selective inhibitors has lagged behind that of soluble proteases.
Claudia Bohg +21 more
wiley +2 more sources
Marine Drugs, 2021 Chitosan nanofiber membranes are recognized as functional antimicrobial materials, as they can effectively provide a barrier that guides tissue growth and supports healing. Methods to stabilize nanofibers in aqueous solutions include acylation with fatty
Carlos Montez Wells +8 more
doaj +1 more source