Results 81 to 90 of about 21,138,684 (162)

2-Bromopalmitate and 2-(2-hydroxy-5-nitro-benzylidene)-benzo[b]thiophen-3-one inhibit DHHC-mediated palmitoylation in vitros⃞

Journal of Lipid Research, 2009
Pharmacologic approaches to studying palmitoylation are limited by the lack of specific inhibitors. Recently, screens have revealed five chemical classes of small molecules that inhibit cellular processes associated with palmitoylation (Ducker, C. E., L.
Benjamin C. Jennings, Marissa J. Nadolski, Yiping Ling, Meredith Beckham Baker, Marietta L. Harrison, Robert J. Deschenes, Maurine E. Linder   +6 more
doaj   +1 more source

Grain setting defect1 (GSD1) function in rice depends on S-acylation and interacts with actin 1 (OsACT1) at its C-terminal

Frontiers in Plant Science, 2015
Grain setting defect1 (GSD1), a plant-specific remorin protein specifically localized at the plasma membrane and plasmodesmata of phloem companion cells, affects grain setting in rice through regulating the transport of photoassimilates.
Jinshan eGui, Shuai eZheng, Junhui eShen, Laigeng eLi   +3 more
doaj   +1 more source

Radiosynthesis, structural identification and in vitro tissue binding study of [18F]FNA-S-ACooP, a novel radiopeptide for targeted PET imaging of fatty acid binding protein 3

EJNMMI Radiopharmacy and Chemistry
Background Fatty acid binding protein 3 (FABP3) is a target with clinical relevance and the peptide ligand ACooP has been identified for FABP3 targeting.
Pyry Dillemuth, Tuomas Karskela, Abiodun Ayo, Jesse Ponkamo, Jonne Kunnas, Johan Rajander, Olli Tynninen, Anne Roivainen, Pirjo Laakkonen, Anu J. Airaksinen, Xiang-Guo Li   +10 more
doaj   +1 more source

SAPPTree: Identification of an S-Acylation Motif Drives a Novel S-Acylation Prediction Program

Abstract S-acylation, the reversible addition of fatty acids to proteins, has emerged as an abundant post-translational modification that drives protein localization and function. With no known consensus sequence, current prediction programs rely on machine learning algorithms that use short peptide sequences and ...
Alyssa S. Guo, Vu Son Luong, Andrey A. Petropavlovskiy, Anthony Dang, Andrew C. Doxey, Shaun S. Sanders, Dale D. O. Martin   +6 more
openaire   +1 more source

An efficient acylation of anilines under sonic conditions

, 2003
Different substituted anilines undergo smooth acylation to give anilides within 60 s in high yields by irradiating at 35 kHz in a sonic bath at 25°C with different acyl ...
Pasha, M.A., Yi Yi Myint, .
core  

Palladium-Catalyzed Direct Acylation: One-Pot Relay Synthesis of Anthraquinones

, 2019
A bis-acylation strategy to access functionalized anthraquinones via one-pot relay process, is presented. The first acylation was feasible under [Pd]-catalyzed intermolecular direct acylation reaction, while, the second acylation was accomplished by ...
Suchand, Basuli, G, Satyanarayana
core   +1 more source

S-acylation and neuroinflammation:the therapeutic potential of zDHHC and deacylase modulation [PDF]

Neuroinflammation is a hallmark of many neurodegenerative diseases, including Alzheimer's, Parkinson's and Huntington's disease, multiple sclerosis, and infantile neuronal ceroid lipofuscinosis.
Ng, Choa P, Duarte, Tiago A, Salvador, Jorge A R, Moreira, Vânia M, Pipito, Ludovico, Greaves, Jennifer; id_orcid   +5 more
core   +1 more source

Micro-scale control of oligodendrocyte morphology and myelination by the intellectual disability-linked protein acyltransferase ZDHHC9

eLife
Mutations in the X-linked ZDHHC9 gene cause cognitive deficits in humans, with a subset of patients suffering from epilepsy. X-linked intellectual disability (XLID) is often ascribed to neuronal deficits, but here we report that expression of human and ...
Hey-Kyeong Jeong, Estibaliz Gonzalez-Fernandez, Ilan Crawley, Julia M Coakley, Jinha Hwang, Dale DO Martin, Shernaz X Bamji, Jong-Il Kim, Shin H Kang, Gareth M Thomas   +9 more
doaj   +1 more source

The S-acylation switch in activated T cells [PDF]

S-acylation is a reversible post-translational modification involving the covalent attachment of a fatty acid to a cysteine residue of a protein. This modification can influence protein conformation, localization, and protein-protein interactions. Due to its reversibility, S-acylation functions as a regulatory switch in various cellular processes ...
openaire   +1 more source

Synthesis of 5-acylindoles via regioselective acylation of 3-trifluoroacetylindole

, 2003
5-Acylindoles were synthesized by regioselective acylation of 3-trifluoroacetylindole with acyl chloride under the catalysis of Lewis acids, followed by hydrolysis of trifluoroacetyl and decarboxylation.
Li, J, Chen, XZ, Zhang, GL, Chinese Acad Sci, Chengdu Inst Biol, Chengdu 610041, Peoples R China., Li, BG, Zhang, GL   +4 more
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