Results 71 to 80 of about 21,138,684 (162)

Guanidine N-methylation by BlsL Is Dependent on Acylation of Beta-amine Arginine in the Biosynthesis of Blasticidin S

Frontiers in Microbiology, 2017
The peptidyl nucleoside blasticidin S (BS) produced by Streptomyces griseochromogenes was the first non-mercurial fungicide used to prevent rice blast and increasingly used as a selection reagent in transgenic study.
Xiankun Wang, Aiqin Du, Guiyang Yu, Zixin Deng, Xinyi He   +4 more
doaj   +1 more source

Going Round in Circles with N→S Acyl Transfer [PDF]

Synlett, 2017
It is not highly sophisticated, yet the N→S acyl transfer reaction of a native peptide sequence potentially fills an important technology gap. While several routes to synthetic peptide thioesters exist, only one is routinely applicable for biologically derived samples. Using the naturally occurring amino acid cysteine as the sole activator for N→S acyl
openaire   +2 more sources

Bioinformatics and Expression Profiling of the DHHC-CRD S-Acyltransferases Reveal Their Roles in Growth and Stress Response in Woodland Strawberry (Fragaria vesca)

Plants
Protein S-acyl transferases (PATs) are a family of enzymes that catalyze protein S-acylation, a post-translational lipid modification involved in protein membrane targeting, trafficking, stability, and protein–protein interaction.
Si Gu, Xinghua Nie, Amal George, Kyle Tyler, Yu Xing, Ling Qin, Baoxiu Qi   +6 more
doaj   +1 more source

Fatty acid acylation of proteins: specific roles for palmitic, myristic and caprylic acids

Oilseeds and fats, crops and lipids, 2016
Fatty acid acylation of proteins corresponds to the co- or post-translational covalent linkage of an acyl-CoA, derived from a fatty acid, to an amino-acid residue of the substrate protein.
Rioux Vincent
doaj   +1 more source

Proteomic analysis of a poplar cell suspension culture suggests a major role of protein S-acylation in diverse cellular processes

Frontiers in Plant Science, 2016
S-acylation is a reversible post-translational modification (PTM) of proteins known to be involved in membrane targeting, subcellular trafficking and the determination of a great variety of functional properties of proteins.
Vaibhav eSrivastava, Joseph R. Weber, Erik eMalm, Bruce William Fouke, Vincent eBulone, Vincent eBulone   +5 more
doaj   +1 more source

Protocol to identify S-acylated proteins in hippocampal neurons using ω-alkynyl fatty acid analogs and click chemistry

STAR Protocols
Summary: S-acylation, commonly palmitoylation, is the addition of fatty acids to cysteines to regulate protein localization and function. S-acylation detection has been hampered by limited sensitivity and selectivity in low-protein, costly samples like ...
Charlotte A. Townsend, Andrey A. Petropavlovskiy, Jordan A. Kogut, Alysha M. Church, Shaun S. Sanders   +4 more
doaj   +1 more source

Global, site-specific analysis of neuronal protein S-acylation

Scientific Reports, 2017
Protein S-acylation (palmitoylation) is a reversible lipid modification that is an important regulator of dynamic membrane-protein interactions. Proteomic approaches have uncovered many putative palmitoylated proteins however, methods for comprehensive ...
Mark O. Collins, Keith T. Woodley, Jyoti S. Choudhary   +2 more
doaj   +1 more source

Microcosmic Mechanism of Dication for Inhibiting Acylation of Acidic Peptide

, 2015
For long-effective peptide formulation based on poly(d,l-lactic-co-glycolic acid) (PLGA) microspheres, acylation often leads to peptide instability during its release and reduced drug efficacy.
Qi, Feng, Wu, Jie, Yang, Liuqing, Ma, Guanghui, Su, Zhiguo   +4 more
core   +1 more source

A chemical proteomics method to quantify Cysteine S-acylation

International audienceS-acylation, often referred to as S-palmitoylation, is a reversible and dynamic post-translational modification which corresponds to the addition of a long-chain fatty acid to cysteine (Cys) residues.
Freyermuth, Chloé, Claverol, Stéphane, Dupuy, Jean-William, Renault, Thibaud, Raymond, Anne-Aurélie, Thinon, Emmanuelle   +5 more
core   +2 more sources

Protein acylation in inflammatory diseases: from mechanisms to therapeutic strategies

Cell Communication and Signaling
Protein acylation, a critical subset of post-translational modifications (PTMs), serves as a dynamic regulatory mechanism linking cellular metabolism, epigenetic regulation, and inflammatory responses.
Jiayi Ding, Huiyi Wang, Zhengkun Yang, Xiaoxuan Wang, Zhengguo Cao   +4 more
doaj   +1 more source