Results 151 to 160 of about 14,441 (168)
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Epigenomics of S-adenosylhomocysteine deficiency
2016S-adenosylhomocysteine (AHCY) hydrolase deficiency is a multisystem methylation disorder caused by point mutations in exons of ahcy gene. Although many advances have been made since the discovery of the disease in 2002, molecular mechanisms of disease pathology are still elusive.
Belužić, Robert +4 more
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1980
S-Adenosylhomocysteine (AdoHcy) (Fig. 1) was first identified as one of the products of the reactions that utilize S-adenosylmethionine (AdoMet) as a methyl donor by Scarano and Cantoni1 in 1954. Over the last 25 years, and especially in the last three or four years, AdoHcy has attracted increasing attention because it has become well established that ...
Giulio L. Cantoni, Peter K. Chiang
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S-Adenosylhomocysteine (AdoHcy) (Fig. 1) was first identified as one of the products of the reactions that utilize S-adenosylmethionine (AdoMet) as a methyl donor by Scarano and Cantoni1 in 1954. Over the last 25 years, and especially in the last three or four years, AdoHcy has attracted increasing attention because it has become well established that ...
Giulio L. Cantoni, Peter K. Chiang
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Contribution of S-adenosylhomocysteine to cardiac adenosine formation
Journal of Molecular and Cellular Cardiology, 1989The S-adenosylhomocysteine (SAH) hydrolase inhibitor adenosine dialdehyde was used in isolated guinea pig hearts to determine the contribution of the transmethylation pathway to cardiac adenosine formation. This inhibitor did not alter cardiac hemodynamics but effectively inhibited SAH-hydrolase activity under in vitro and in vivo conditions.
A, Deussen, H G, Lloyd, J, Schrader
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Glutathione changes occurring after S-adenosylhomocysteine hydrolase inhibition
Archives of Biochemistry and Biophysics, 1985Freshly isolated rat hepatocytes, which metabolize methionine through the cystathionine pathway, and cultured L5178Y cells, which do not, were compared for their response to the inhibition of S-adenosylhomocysteine (SAH) hydrolase (EC 3.3.1.1). When cells were incubated in Fischer's medium lacking cystine but containing 0.67 mM methionine and 10% serum,
A E, Brodie, D J, Reed
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Interrelations Between Plasma Homocysteine and Intracellular S-Adenosylhomocysteine
Biochemical and Biophysical Research Communications, 2000S-Adenosylhomocysteine, a potent intracellular methylation inhibitor, is suggested as a potential mediator for hyperhomocysteinemia-related vascular changes. We investigated the effect of acute and chronic hyperhomocysteinemia on intracellular S-adenosylhomocysteine and S-adenosylmethionine in rats and humans.
W, Fu +4 more
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S-Adenosylhomocysteine Metabolism in Adenosine Deaminase Deficient Cells
1980At the Second International Symposium on Purine Metabolism (Baden, 1976) there was much discussion of the potential role of adenosine cytotoxicity as a cause for the immune defect associated with adenosine deaminase (ADA) deficiency. Since then attention has shifted to the role of deoxyadenosine toxicity with the discovery of elevated dATP pools in ...
M S, Hershfield, N M, Kredich
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Effect of S-adenosylhomocystein on color avoidance behavior
Pharmacology Biochemistry and Behavior, 1980The intracranial injection of an inhibitor of the enzyme hydroxyindole-O-methyltransferase (S-adenosylhomocystein: SAH) in goldfish prior to color avoidance training caused delay in responding to either white or green conditioned stimulus in the shuttlebox. Latency of the responses to red or blue conditioned stimulus was not affected by an injection of
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[194] S-adenosylhomocysteine nucleosidase (Escherichia coli)
1971Publisher Summary This chapter discusses the methods of preparation of S-Adenosylhomocysteine Nucleosidase ( Escherichia coli ). The rate of hydrolysis of the glycosyl linkage of S-adenosylhomocysteine to form adenine and ribosylhomocysteine is followed by measuring the rate of formation of aldehydic groups.
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Biological Effects of Inhibitors of S-Adenosylhomocysteine Hydrolase
Pharmacology & Therapeutics, 1998S-Adenosylhomocysteine (AdoHcy), formed after the donation of the methyl group of S-adenosylmethionine to a methyl acceptor, is hydrolyzed to adenosine and homocysteine by AdoHcy hydrolase physiologically. The administration of the inhibitors of AdoHcy hydrolase to cells or animals normally results in an accumulation of cellular AdoHcy higher than ...
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Homocysteine, S-adenosylmethionine and S-adenosylhomocysteine
2008Homocysteine and the related metabolites S-adenosylmethionine and S-adenosylhomocysteine play a vital role in several vital biological processes. Disturbed levels are found in inborn errors of methionine metabolism as well as in other pathological states such as vitamin B12 or folate deficiency and renal disease.
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