Results 161 to 170 of about 15,817,770 (195)

Influence of S-adenosylhomocysteine hydrolase inhibitors on S-adenosylhomocysteine and S-adenosylmethionine pool levels in L929 cells

Biochemical Pharmacology, 1990
S-Adenosylhomocysteine hydrolase has been recognized as the target enzyme for the antiviral activity of several carbocyclic and acyclic adenosine analogues. In a previous study [Cools M and De Clercq E, Biochem Pharmacol 38: 1061-1067, 1989], we found a close correlation between the antiviral activity of six adenosine analogues [S)-9-(2,3 ...
M, Cools, E, De Clercq
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Microsomal phosphatidylethanolamine methyltransferase: Inhibition by S‐adenosylhomocysteine

Lipids, 1981
AbstractInhibition by S‐adenosylhomocysteine (AdoHcy) of the three reactions of phosphatidylethanolamine methyltransferase which catalyzes the production of phosphatidylcholine from phosphatidyl‐ethanolamine in guinea pig and rat liver microsomes has been evaluated. Five of the six methylation reactions in these two species exhibit greater affinity for
D R, Hoffman, J A, Haning, W E, Cornatzer   +2 more
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Inhibition of indolethylamine-N-methyltransferase by S-Adenosylhomocysteine

Biochemical and Biophysical Research Communications, 1973
Abstract S -Adenosylhomocysteine (SAH) is a potent product inhibitor for indoleamine- N -methyltransferase (INMT) from rabbit lung. The kinetic studies showed that this inhibition was competitive with respect to S -adenosylmethionine (SAM) and noncompetitive with respect to N -methylserotonin (NMS). The K i value of 1.0 ×
R L, Lin, N, Narasimhachari, H E, Himwich   +2 more
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Adenosine analogue inhibitors of S-adenosylhomocysteine hydrolase

Bioorganic & Medicinal Chemistry Letters, 2014
Elevated plasma homocysteine (Hcy) levels are an independent risk factor for the onset and progression of Alzheimer's disease. Reduction of Hcy to normal levels therefore presents a new approach for disease modification. Hcy is produced by the cytosolic enzyme S-adenosylhomocysteine hydrolase (AHCY), which converts S-adenosylhomocysteine (SAH) to Hcy ...
Antonella, Converso, Timothy, Hartingh, Mark E, Fraley, Robert M, Garbaccio, George D, Hartman, Shaei Y, Huang, John M, Majercak, Alexander, McCampbell, Sang Jin, Na, William J, Ray, Mary J, Savage, Carrie, Wolffe, Suzie, Yeh, Yuanjiang, Yu, Rebecca, White, Rena, Zhang   +15 more
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Contribution of S-adenosylhomocysteine to cardiac adenosine formation

Journal of Molecular and Cellular Cardiology, 1989
The S-adenosylhomocysteine (SAH) hydrolase inhibitor adenosine dialdehyde was used in isolated guinea pig hearts to determine the contribution of the transmethylation pathway to cardiac adenosine formation. This inhibitor did not alter cardiac hemodynamics but effectively inhibited SAH-hydrolase activity under in vitro and in vivo conditions.
A, Deussen, H G, Lloyd, J, Schrader
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S-Adenosylhomocysteine Assay in the Urine by Capillary Electrophoresis

Bulletin of Experimental Biology and Medicine, 2015
We present a simple and effective method for measuring urine S-adenosylhomocysteine by capillary electrophoresis without using modifiers. The detection threshold of the method is 0.1 μM S-adenosylhomocysteine, the time of analysis 13 min, reproducibility at physiological concentrations within 4%.
B P, Luzyanin, A V, Ivanov, E D, Viryus, A A, Kubatiev   +3 more
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The effect of aliphatic adenine analogues on S-adenosylhomocysteine and S-adenosylhomocysteine hydrolase in intact rat hepatocytes.

Molecular Pharmacology, 1984
The aliphatic adenine analogues, D-eritadenine, L-eritadenine, L-threoeritadenine, and 9-(S)-(2,3-dihydroxypropyl)adenine [(S)DHPA] function as inhibitors/inactivators of purified S-adenosylhomocysteine (AdoHcy) hydrolase, but these compounds did not induce reduction of enzyme-bound NAD+.
J S, Schanche, T, Schanche, P M, Ueland, A, Holý, I, Votruba   +4 more
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S-Adenosylhomocysteine hydrolase activity in human myocardium

Cardiovascular Research, 1992
Measurement of S-adenosylhomocysteine (SAH) accumulation in the heart reflects the concentration of free cytosolic adenosine and is thus a sensitive indicator of regional myocardial ischaemia. To evaluate the possibility of applying this method in combination with 11C-SAH positron emission tomography (PET) to patients with ischaemic heart disease the ...
M M, Borst, A, Deussen, J, Schrader
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Enzymatic synthesis of S-adenosylhomocysteine: immobilization of recombinant S-adenosylhomocysteine hydrolase from Corynebacterium glutamicum (ATCC 13032)

Applied Microbiology and Biotechnology, 2011
Recombinant S-adenosylhomocysteine hydrolase from Corynebacterium glutamicum (CgSAHase) was covalently bound to Eupergit® C. The maximum yield of bound protein was 91% and the catalytic efficiency was 96.9%. When the kinetic results for the immobilized enzyme were compared with those for the soluble enzyme, no decrease in the catalytic efficiency of ...
J D, Lozada-Ramírez, A, Sánchez-Ferrer, F, García-Carmona   +2 more
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S-Adenosylhomocysteine hydrolase deficiency

2008
S-Adenosylhomocysteine hydrolase (AdoHcy) deficiency is a disorder in methionine metabolism. The enzyme catalyzes the hydrolysis of S-adenosylhomocysteine to homocysteine and adenosine. Its deficiency in human was first reported in 2003. Since then few other patients have been identified.
Ćuk, Mario, Barić, Ivo, Vugrek, Oliver, Fumić, Ksenija   +3 more
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