Results 151 to 160 of about 15,817,770 (195)
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Binding of S-adenosylhomocysteine to hydroxyindole O-methyltransferase
BBA - Proteins and Proteomics, 1984Biochim Biophys Acta 1984 May 31;787(1 ) 1-7 (S-adenosyl-L-methionine:N-acetylserotonin O-methyltransferase, EC 2.1.1.4) purified from bovine pineal gland forms a complex with S-adenosylhomocysteine, one of the products of the reaction catalyzed by the enzyme. The binding of S-adenosylhomocysteine to the enzyme has been characterized by the use of S-[8-
R Kuwano, Ryozo Kuwano
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Biological Effects of Inhibitors of S-Adenosylhomocysteine Hydrolase
Pharmacology & Therapeutics, 1998S-Adenosylhomocysteine (AdoHcy), formed after the donation of the methyl group of S-adenosylmethionine to a methyl acceptor, is hydrolyzed to adenosine and homocysteine by AdoHcy hydrolase physiologically. The administration of the inhibitors of AdoHcy hydrolase to cells or animals normally results in an accumulation of cellular AdoHcy higher than ...
P K Chiang, Peter K Chiang
exaly +3 more sources
L-Propionyl carnitine, homocysteine and S-adenosylhomocysteine in hemodialysis [PDF]
Journal of Nephrology, 2007 Abstract Background: L-Carnitine, the acyl carrier into mitochondria, is derived from trimethyllysine. The formation of the latter compound is catalyzed by an S-adenosylmethionine methyltransferase, yielding S-adenosylhomocysteine (AdoHcy), the homocysteine direct precursor, as a product.
PERNA, Alessandra +6 more
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Role of elevated S-adenosylhomocysteine in rat hepatocyte apoptosis: Protection by betaine [PDF]
Biochemical Pharmacology, 2005 Previous studies from our laboratory have shown that ethanol consumption results in an increase in hepatocellular S-adenosylhomocysteine levels. Because S-adenosylhomocysteine is a potent inhibitor of methylation reactions, we propose that increased ...
Kusum Kharbanda +2 more
exaly +3 more sources
Medical Hypotheses, 2004
Objective is to speculate on the ribavirin induced anemia by inhibiting S-adenosylhomocysteine (SAH)-hydrolase activity. The major toxicity associated with the use of ribavirin is hemolytic anemia. This adverse effect has been ascribed to the accumulation of ribavirin triphosphate in the erythrocyte, which interferes with erythrocyte function ...
Engin, Altintas, Orhan, Sezgin
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Objective is to speculate on the ribavirin induced anemia by inhibiting S-adenosylhomocysteine (SAH)-hydrolase activity. The major toxicity associated with the use of ribavirin is hemolytic anemia. This adverse effect has been ascribed to the accumulation of ribavirin triphosphate in the erythrocyte, which interferes with erythrocyte function ...
Engin, Altintas, Orhan, Sezgin
openaire +3 more sources
1986
S-Adenosylhomocysteine (AdoHcy) hydrolase (EC 3.3.1.1.), the enzyme responsible for the metabolic degradation of the endogenous transmethylase inhibitor, AdoHcy, is a target enzyme for various adenosine analogues. Some of these compounds have oncostatic and antiviral properties.
S, Helland, P M, Ueland
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S-Adenosylhomocysteine (AdoHcy) hydrolase (EC 3.3.1.1.), the enzyme responsible for the metabolic degradation of the endogenous transmethylase inhibitor, AdoHcy, is a target enzyme for various adenosine analogues. Some of these compounds have oncostatic and antiviral properties.
S, Helland, P M, Ueland
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A colorimetric assay for S-adenosylhomocysteine hydrolase
Journal of Biochemical and Biophysical Methods, 2006A colorimetric method for S-adenosyl-L-homocysteine hydrolase (SAHase) which uses S-adenosyl-L-homocysteine (SAH) as substrate is described. This method involves the hydrolytic conversion of SAH into adenosine (ADO) and L-homocysteine (HCY). The formation of HCY is quantified using Ellman's reagent and spectrophotometrical measured at 412 nm.
J D, Lozada-Ramírez +3 more
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1980
S-Adenosylhomocysteine (AdoHcy) (Fig. 1) was first identified as one of the products of the reactions that utilize S-adenosylmethionine (AdoMet) as a methyl donor by Scarano and Cantoni1 in 1954. Over the last 25 years, and especially in the last three or four years, AdoHcy has attracted increasing attention because it has become well established that ...
Giulio L. Cantoni, Peter K. Chiang
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S-Adenosylhomocysteine (AdoHcy) (Fig. 1) was first identified as one of the products of the reactions that utilize S-adenosylmethionine (AdoMet) as a methyl donor by Scarano and Cantoni1 in 1954. Over the last 25 years, and especially in the last three or four years, AdoHcy has attracted increasing attention because it has become well established that ...
Giulio L. Cantoni, Peter K. Chiang
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Cell Differentiation, 1988
We have analyzed the level of substrate (AdoMet) and products (AdoHcy) of transmethylations throughout the developmental cycle of the primitive eukaryote Dictyostelium discoideum. The ratio AdoMet/AdoHcy varied dramatically during differentiation. The intracellular level of AdoHcy decreased sharply after the beginning of starvation reaching a value of ...
M C, Guitton +5 more
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We have analyzed the level of substrate (AdoMet) and products (AdoHcy) of transmethylations throughout the developmental cycle of the primitive eukaryote Dictyostelium discoideum. The ratio AdoMet/AdoHcy varied dramatically during differentiation. The intracellular level of AdoHcy decreased sharply after the beginning of starvation reaching a value of ...
M C, Guitton +5 more
openaire +2 more sources
S-Adenosylhomocysteine Hydrolase
1986S-Adenosylhomocysteine hydrolase (AdoHcyase; EC 3.3.1.1) catalyzes the overall reaction first described by de la Haba and Cantoni (1957):
Peter K. Chiang, George A. Miura
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