Results 121 to 130 of about 25,478 (242)

Genetic screening reveals phospholipid metabolism as a key regulator of the biosynthesis of the redox-active lipid coenzyme Q

Redox Biology, 2021
Mitochondrial energy production and function rely on optimal concentrations of the essential redox-active lipid, coenzyme Q (CoQ). CoQ deficiency results in mitochondrial dysfunction associated with increased mitochondrial oxidative stress and a range of
Anita Ayer, Daniel J. Fazakerley, Cacang Suarna, Ghassan J. Maghzal, Diba Sheipouri, Kevin J. Lee, Michelle C. Bradley, Lucía Fernández-del-Rio, Sergey Tumanov, Stephanie MY. Kong, Jelske N. van der Veen, Andrian Yang, Joshua W.K. Ho, Steven G. Clarke, David E. James, Ian W. Dawes, Dennis E. Vance, Catherine F. Clarke, René L. Jacobs, Roland Stocker   +19 more
doaj  

Characterization of S -Adenosylmethionine: Ribosomal Ribonucleic Acid-Adenine (N ⁶ -) Methyltransferase of Escherichia coli Strain B [PDF]

, 1972
Jerry E. Sipe, W.Marshall Anderson, Charles N. Remy, Samuel H. Love   +3 more
openalex   +1 more source

If you cannot see it, is it still there?

Journal of Applied Crystallography, Volume 58, Issue 2, Page 615-621, April 2025.
Flexible segments of protein molecules, while known to be present in a structure, are often not visible in the electron density and are thus omitted in models. Ensemble refinement of completed models allows for visualization and exploration of the available conformation space of such `invisible' regions.
Lukas Leitner, Jesse Hudspeth, Sebastiaan Werten, Bernhard Rupp   +3 more
wiley   +1 more source

Mechanistic Studies on the Radical S-Adenosylmethionine Enzymes Involved in Molybdopterin, Thiamin and Vitamin B12 Biosynthesis [PDF]

, 2015
This dissertation focuses on radical S-adenosylmethionine enzymes involved in cofactor biosynthesis. Mechanistic studies discussed here include: (i) molybdenum cofactor biosynthetic enzyme - MoaA, (ii) thiamin pyrimidine synthase – ThiC (iii ...
Mehta, Angad P
core  

Density Functional Theory Investigation of As(III) S‑Adenosylmethionine Methyltransferase

ACS Omega, 2020
Seth A. Friesen, Jesse B. Elder, Eric A. C. Bushnell   +2 more
doaj   +1 more source

S-adenosylmethionine: DNA-cytosine 5-methyltransferase from a Novikoff rat hepatoma cell line [PDF]

, 1975
Thomas W. Sneider, W. Martin Teague, L.M. Rogachevsky   +2 more
openalex   +1 more source

DNMT3a Deficiency Contributes to Anesthesia/Surgery‐Induced Synaptic Dysfunction and Cognitive Impairment in Aged Mice

Aging Cell, Volume 24, Issue 4, April 2025.
DNMT3a downregulation appears to causally contribute to surgery‐induced cognitive impairment, whereas its overexpression effectively alleviated cognitive impairment behaviors. Mechanistically, DNMT3a downregulation induced by anesthesia/surgery could disrupt DNA methylation stability in the hippocampus of aged mice. This decreased the binding of DNMT3a
Peilin Cong, Xinwei Huang, Qian Zhang, Mengfan He, Hanxi Wan, Qianqian Wu, Huanghui Wu, Yuxin Zhang, Chun Cheng, Li Tian, Lize Xiong   +10 more
wiley   +1 more source

SARS-CoV-2 and HCoV-OC43 regulate host m6A modification via activation of the mTORC1 signalling pathway to facilitate viral replication

Emerging Microbes and Infections
N6-methyladenosine (m6A) is the most prevalent post-transcriptional modification in eukaryotic RNA and is also present in various viral RNAs, where it plays a crucial role in regulating the viral life cycle.
Shixiong Zhou, Xianfeng Hui, Weiwei Wang, Chunbei Zhao, Meilin Jin, Yali Qin, Mingzhou Chen   +6 more
doaj   +1 more source

Cyclic AMP-dependent protein kinase mediates a cyclic AMP-stimulated decrease in ornithine and S-adenosylmethionine decarboxylase activities. [PDF]

, 1978
Paul A. Insel, J. Christopher Fenno
openalex   +1 more source

Longevity Humans Have Youthful Erythrocyte Function and Metabolic Signatures

Aging Cell, Volume 24, Issue 5, May 2025.
Longevity humans have “a youthful erythrocyte function and metabolism” with a youth‐like oxygen release and anti‐oxidative capability to combat tissue hypoxia and improve healthspan. ABSTRACT Longevity individuals have lower susceptibility to chronic hypoxia, inflammation, oxidative stress, and aging‐related diseases.
Fang Yu, Changhan Chen, Wuping Liu, Zhixiang Zhao, Yuhua Fan, Zhenjiang Li, Weilun Huang, Tingting Xie, Cheng Luo, Zhouzhou Yao, Qi Guo, Zhiyu Yang, Juan Liu, Yujin Zhang, Rodney E. Kellems, Jian Xia, Ji Li, Yang Xia   +17 more
wiley   +1 more source