Results 131 to 140 of about 60,031 (297)

Exploring the Key Role of Nanotechnology on Intratumoral Microbiome Modulation for Cancer Immunotherapy

open access: yesMedComm – Biomaterials and Applications, Volume 5, Issue 1, March 2026.
The review provides a comprehensive analysis of microbiome‐mediated oncogenic mechanisms in various cancers, emphasizing the unique therapeutic strategies facilitated by nanotechnology. It aims to fill this gap by systematically reviewing nanotechnology‐driven strategies for microbiome elimination, with a focus on their ability to improve the cold TME ...
Yumei Gan, Yan Zhang, Xia Dong, Feng Lv
wiley   +1 more source

Aging‐Derived Alterations in Genomic, Immune, and Metabolic Networks: Implications for Cancer Development and Therapy

open access: yesMedComm – Oncology, Volume 5, Issue 1, March 2026.
Ageing acts as a double‐edged sword in cancer. In the elderly, open chromatin, immunosenescence, and chronic inflammation drive SASP (IL‐6, MMPs), MDSC accumulation and T‐cell suppression, fostering tumor‐promoting microenvironments and limited therapeutic benefit.
Qi Wang   +7 more
wiley   +1 more source

Metabolic reprogramming of efferocytosis in the tumour microenvironment: From apoptotic‐cell clearance to therapeutic targeting

open access: yesClinical and Translational Medicine, Volume 16, Issue 2, February 2026.
This review systematically deconstructs the pathological efferocytic—metabolic axis in tumours, framing it as a three‐stage, self‐reinforcing cycle: from metabolite‐driven macrophage recruitment, through hijacked surface recognition, to post‐phagocytic metabolic reprogramming that locks in immunosuppression.
Qianlu Yang, Jie Yan, Qianxi Yang
wiley   +1 more source

Paleoproterozic Icehouses and the Evolution of Oxygen Mediating Enzymes: The Case for a Late Origin of Photosystem -- II [PDF]

open access: yes, 2008
Two major geological problems regarding the origin of oxygenic photosynthesis are: (1) identifying a source of oxygen predating biological oxygen production and capable of driving the evolution of oxygen tolerance, and (2) determining when oxygenic ...
Kirschvink, Joseph L., Kopp, Robert E.
core  

The crystal structure of human S-adenosylmethionine decarboxylase at 2.25 Å resolution reveals a novel fold [PDF]

open access: bronze, 1999
J.L. Ekstrom   +4 more
openalex   +1 more source

Loss of METTL3 m6A methyltransferase results in short‐term progression and poor treatment outcome of bladder cancer patients

open access: yesInternational Journal of Cancer, Volume 158, Issue 3, Page 763-774, 1 February 2026.
What's new? Bladder cancer exhibits a highly heterogeneous molecular landscape and treatment response. The dysregulation of RNA modifications such as m6A has been involved in cancer initiation and progression. This study comprehensively analyzed the expression of the main catalytic component of the m6A methylation machinery in bladder tumors across one
Katerina‐Marina Pilala   +10 more
wiley   +1 more source

SARS-CoV-2 and HCoV-OC43 regulate host m6A modification via activation of the mTORC1 signalling pathway to facilitate viral replication

open access: yesEmerging Microbes and Infections
N6-methyladenosine (m6A) is the most prevalent post-transcriptional modification in eukaryotic RNA and is also present in various viral RNAs, where it plays a crucial role in regulating the viral life cycle.
Shixiong Zhou   +6 more
doaj   +1 more source

Nutritional approach in a growing Jack Russell terrier with gall bladder agenesis

open access: yesVeterinary Record Case Reports, Volume 14, Issue 1, February 2026.
Abstract An asymptomatic male Jack Russell terrier diagnosed at the age of 18 weeks with congenital gall bladder agenesis, confirmed by computed tomography scan, after finding abnormally high values for liver enzymes in a routine blood count. Treatment with liver‐protective agents S‐adenosylmethionine and ursodeoxycholic acid was initiated. At 6 months
Tamara Seghers   +3 more
wiley   +1 more source

Hyalohyphomycotic chronic rhinosinusitis caused by Microascus cirrosus in a cat

open access: yesVeterinary Record Case Reports, Volume 14, Issue 1, February 2026.
Abstract A 13‐year‐old, male, neutered, indoor‐only, domestic long‐haired cat was presented with an 8‐month history of sneezing and a 2‐month history of epistaxis. Computed tomography demonstrated an irregular contrast‐enhancing soft tissue opacity within both nasal cavities and osteolysis of surrounding bony structures.
Leonel Frutuoso   +4 more
wiley   +1 more source

Overexpression of S-adenosylmethionine decarboxylase (SAMDC) activates the maternal program of apoptosis shortly after MBT in Xenopus embryos [PDF]

open access: bronze, 2000
Masayuki Kai   +8 more
openalex   +1 more source

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