Results 81 to 90 of about 234 (145)

Ocrelizumab‐induced colitis: VigiBase disproportionality analysis, case reports and literature review

British Journal of Clinical Pharmacology, Volume 92, Issue 7, Page 2162-2170, July 2026.
Aims Ocrelizumab is a humanized anti‐CD20 monoclonal antibody used in multiple sclerosis. Since its commercialization, several cases of ocrelizumab‐induced colitis have been reported in the scientific literature. Methods To explore the potential association of ocrelizumab with colitis as an adverse drug reaction (ADR), we conducted a descriptive and ...
Audrey Fresse, Christophe Hommel, Nadine Petitpain, Philippe Kerschen   +3 more
wiley   +1 more source

The quantitative impact of metabolism‐inhibiting drugs on the occurrence of adverse drug reactions—A backward selection approach

British Journal of Clinical Pharmacology, Volume 92, Issue 7, Page 2203-2211, July 2026.
Abstract Aim The quantitative effect of several inhibitory drugs on the development of adverse drug reactions (ADRs) is currently difficult to estimate. Our aim was to identify metabolic pathways, which, when inhibited, increase the risk for certain ADRs, and to use this system to consider comedication at individual level. Methods Data of a prospective
Judith Berres, Justyna Wozniak, Hannah Fölsch, Anja Knueppel‐Ruppert, Verena Graeff, Andrea Kriegisch‐Stumpf, Harald Dormann, Julia C. Stingl, Katja S. Just   +8 more
wiley   +1 more source

Chiral (Stereoselective) Drugs, Asymmetric Synthesis, and Racemic Resolution Methods

Chirality, Volume 38, Issue 7, July 2026.
Chirality is crucial in drug development since both biological targets in the organism and the majority of pharmaceutical compounds are chiral. The synthesis and resolution of chiral compounds are critical steps while developing chiral drugs. Asymmetric synthesis and racemic resolution are the two most common methods for obtaining enantiopure drugs ...
Burcu Karayavuz, Cigdem Karaaslan Kirmizioglu   +1 more
wiley   +1 more source

Can a Lifestyle‐Centred, Low‐Dose Model Improve Hypertension and Diabetes Care in Low‐ and Middle‐Income Countries? Real‐World Implementation Data From Zambia

Lifestyle Medicine, Volume 7, Issue 3, July 2026.
ABSTRACT Introduction Hypertension and Type 2 diabetes are major contributors to the growing burden of non‐communicable diseases in rural Zambia. Lifestyle interventions are central to prevention and management, yet implementation remains limited in resource‐constrained settings.
Keith Birrell, Ginny Birrell, Fastone Goma   +2 more
wiley   +1 more source

Vat Polymerization 3D Printing for Controlled Drug Release Applications

Advanced Materials Technologies, Volume 11, Issue 11, 5 June 2026.
ABSTRACT Vat polymerization (VP) 3D printing, a light‐based additive manufacturing technique, has emerged as a promising technique for fabricating complex drug delivery systems with high precision and spatial resolution. This layer‐by‐layer manufacturing process enables the creation of intricate geometries and customizable architectures, which are ...
Hafiz Busari, O. Thompson Mefford, M. Aaron Vaughn   +2 more
wiley   +1 more source

Clinical pharmacology and prescribing education: An updated medical school curriculum from the British Pharmacological Society

British Journal of Clinical Pharmacology, Volume 92, Issue 6, Page 1787-1808, June 2026.
Aims Prescribing is a complex, essential skill that doctors must acquire to practice medicine safely and effectively. The British Pharmacological Society has historically provided a core curriculum to guide clinical pharmacology and prescribing education in UK medical schools.
Dagan O. Lonsdale, Clare Guilding, Jennifer Koenig, Michael Okorie, Reecha Sofat, Simon Maxwell   +5 more
wiley   +1 more source

Transcranial Direct Current Stimulation (tDCS) for the Treatment of Hemolacria Comorbid With Psychiatric and Somatic Symptoms: A Case Report

Clinical Case Reports, Volume 14, Issue 6, June 2026.
ABSTRACT Hemolacria is a rare condition characterized by bloody tears. Its etiology is often multifactorial, but functional/psychosomatic mechanisms have been proposed when organic causes are excluded. A 48‐year‐old woman with a history of multiple traumatic brain injuries (coma in 2008, car accident in 2017) presented with refractory generalized ...
Roghayeh Mohammadi, Ahmad Alipour
wiley   +1 more source

Comparative assessment of arterial stiffness and endothelial dysfunction during treatment with fixed combinations of antihypertensive drugs in patients with arterial hypertension and coronary artery disease

Consilium Medicum
Aim. To evaluate and compare the efficacy and safety of two triple fixed combinations (FC) of antihypertensive drugs, amlodipine/indapamide/perindopril and amlodipine/valsartan/hydrochlorothiazide (HCTZ), in managing the clinical course in patients with ...
Inara А. Khakuasheva, Murat A. Umetov, Janneta M. Urusbieva, Alena Kh. Abukova, Liana A. Didanova   +4 more
doaj   +1 more source

BRASH Syndrome

Clinical Case Reports, Volume 14, Issue 6, June 2026.
ABSTRACT BRASH syndrome is a life‐threatening clinical entity characterized by Bradycardia, Renal failure, Atrioventricular (AV) blockade, Shock, and Hyperkalemia. This syndrome is often triggered in patients on AV nodal blocking agents who develop acute kidney injury, leading to a “vicious cycle” of worsening bradycardia and renal dysfunction.
Sowdo Nur Iyow, Abdisamad Mohamed Adam, Hassan Adan Ali Adan, Abdulkadir Sağdıç, Ahmed Yusuf Mohamed   +4 more
wiley   +1 more source

Analysis of Adherence to Antihypertensive Drugs in Chinese Patients with Hypertension: A Retrospective Analysis Using the China Health Insurance Association Database 

Patient Preference and Adherence, 2020
Bin Cui,1 Zhaohui Dong,2 Mengmeng Zhao,3 Shanshan Li,4 Hua Xiao,4 Zhitao Liu,4 Xiaowei Yan5 1School of Public Health, Peking University, Beijing 100191, People’s Republic of China; 2Human Resources and Social Security, Chinese Academy of Labour and
Cui B, Dong Z, Zhao M, Li S, Xiao H, Liu Z, Yan X   +6 more
doaj