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Enrichment of S-Palmitoylated Proteins for Mass Spectrometry Analysis
2019As the 10-year anniversary of their first introduction approaches, alkynyl fatty acids have revolutionized the analysis of S-palmitoylation dynamics, acting as functional mimics incorporated into native modification sites in cultured cells. The alkyne functional group provides a robust handle for bioorthogonal Cu(I)-catalyzed azide-alkyne cycloaddition
Melanie, Cheung See Kit, Brent R, Martin
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Recapitulating the potential contribution of protein S-palmitoylation in cancer
Cancer and Metastasis ReviewsProtein S-palmitoylation is a reversible form of protein lipidation in which the formation of a thioester bond occurs between a cysteine (Cys) residue of a protein and a 16-carbon fatty acid chain. This modification is catalyzed by a family of palmitoyl acyl transferases, the DHHC enzymes, so called because of their Asp-His-His-Cys (DHHC) catalytic ...
Suchi, Chaturvedi, Avinash, Sonawane
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Protein S-palmitoylation enhances profibrotic signaling in response to cadmium
Toxicology and Applied PharmacologyCadmium (Cd) is a naturally occurring, toxic environmental metal found in foods. Humans do not have an efficient mechanism for Cd elimination; thus, Cd burden in humans increases with age. Cell and mouse studies show that Cd burden from low environmental levels of exposure impacts lung cell metabolism, proliferation signaling and cell growth as part of
Choon-Myung, Lee +7 more
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S-palmitoylation in ferroptosis: molecular mechanisms, modulators, and interplay with autophagy
ApoptosisS-palmitoylation, a reversible lipid post-translational modification, plays a dynamically regulatory role in cell death signaling pathways by modulating protein-membrane affinity, subcellular localization, and functional interactions. Emerging evidence has linked dysregulated S-palmitoylation to various pathologies including cancer and ...
Leilei, Wang, Chuan, Wang, Hong, He
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S-palmitoylation in bone biology: emerging insights and therapeutic potential
Biochemical PharmacologyS-Palmitoylation, the reversible covalent attachment of palmitate to cysteine residues, is a dynamic post-translational lipid modification that regulates the localization, stability, and function of a wide array of proteins. Although traditionally linked to membrane trafficking and signaling, recent preliminary studies have begun to reveal its ...
Xing Ji +4 more
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The shadow of cancer therapeutic resistance: Unveiling the role of S-palmitoylation
Drug Resistance UpdatesCancer therapeutic resistance remains a formidable challenge due to its diverse underlying mechanisms. S-palmitoylation (or called S-acylation), a reversible post-translational modification involving the attachment of long-chain fatty acids to cysteine residues, has emerged as a critical regulator of cancer progression and treatment response.
Xue, Yang +3 more
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Insights into the molecular basis of the palmitoylation and depalmitoylation of NCX1
Cell Calcium, 2021Niall J Fraser +2 more
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