Oxidative Stress in the Tumor Immune Microenvironment: Mechanisms and Therapeutic Perspectives
MedComm – Oncology, Volume 5, Issue 2, June 2026.Oxidative stress is involved in several key processes in cancer, including redox regulation, DNA damage, post‐translational modifications, transcriptional regulation, epigenetic modifications, metabolic reprogramming, cell death, and immune modulation. These mechanisms collectively influence tumor progression, immune evasion, and therapeutic responses,
Zhen Wang +14 more
wiley +1 more source
Syntaxin 1A Transmembrane Domain Palmitoylation Induces a Fusogenic Conformation
Neurotransmitter release is triggered by the fusion of synaptic vesicles with the plasma membrane, orchestrated by SNARE proteins Synaptobrevin 2 (Syb2), Syntaxin 1A (Stx1A), and SNAP25.
Lindau, Manfred +2 more
core +1 more source
Dysregulated Lipid Metabolism in Hepatocellular Carcinoma: Mechanisms and Therapeutic Strategies
MedComm – Oncology, Volume 5, Issue 2, June 2026.Dysregulated lipid metabolism facilitates hepatocellular carcinoma (HCC) development, progression, immunosuppressive tumor microenvironment (TME) formation, and therapeutic resistance. Notably, the patterns of lipid metabolism vary significantly among different types of HCC driven by various etiologies.
Yi Yi +4 more
wiley +1 more source
GRKs and arrestins: Nomenclature and functions in GPCR‐dependent and ‐independent signalling
British Journal of Pharmacology, Volume 183, Issue 11, Page 2619-2633, June 2026.G protein‐coupled receptor (GPCR) kinases (GRKs) and arrestins play a critical role in the regulation of GPCR signalling. Historic names of mammalian GRKs were replaced by systematic ones in the 1990s; however, both kinds of names are currently in use for mammalian arrestins.
Vsevolod V. Gurevich
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Immune Evasion of Helicobacter pylori and Extra‐Gastric Cancer Risk
Journal of Gastroenterology and Hepatology, Volume 41, Issue 6, Page 1722-1742, June 2026.ABSTRACT Helicobacter pylori (H. pylori) is a group 1 gastric carcinogen that plays a significant role in extra‐gastric digestive system cancers. H. pylori disrupts host cell homeostasis through expression of virulence factors leading to immune evasion as well as persistent gastric mucosal colonization. H. pylori infection has been shown to play a role
Evren Doruk Engin +2 more
wiley +1 more source
Journal of Neurochemistry, Volume 170, Issue 6, June 2026.Ischemic insult causes hyper‐glutamatergic signaling and neuronal death. The astrocytic transporter GLT‐1, which clears extracellular glutamate, is internalized and degraded in response to ischemia. We found that lysine‐directed post‐translational modifications (particularly ubiquitination) of the C‐terminal domain drive aberrant trafficking ...
Simran Kaur Gill +4 more
wiley +1 more source
Reversible S-palmitoylation of C4 protein encoded by TYLCCxV orchestrates geminiviral pathogenesis. [PDF]
Stress BiolXie Y +9 more
europepmc +1 more source
New Phytologist, Volume 250, Issue 5, Page 3230-3246, June 2026.Summary Carotenoids and apocarotenoids are widespread specialized metabolites, yet animals, including sponges, lack the ability to synthesize carotenoids de novo and must obtain them from dietary or microbial sources. The roles of carotenoid cleavage dioxygenases (CCDs) in marine animals remain largely unexplored. A CCD from the marine sponge Suberites
Elena Moreno‐Giménez +11 more
wiley +1 more source
S-palmitoylation regulates the function of the mitochondria-associated endoplasmic reticulum membrane to alleviate the senescence of nucleus pulposus cells. [PDF]
PLoS OneLiang Q +8 more
europepmc +1 more source
Identification of <i>SmNAC28</i> Transcription Factor and Its Mechanism of Regulating Salt Tolerance in Eggplant via S-Palmitoylation. [PDF]
Curr Issues Mol BiolFan Y, Xu C, Chen Q, Hu W, Ji T, Yang F.
europepmc +1 more source