Results 201 to 210 of about 15,826,951 (219)

Recapitulating the potential contribution of protein S-palmitoylation in cancer

Cancer and Metastasis Reviews
Protein S-palmitoylation is a reversible form of protein lipidation in which the formation of a thioester bond occurs between a cysteine (Cys) residue of a protein and a 16-carbon fatty acid chain. This modification is catalyzed by a family of palmitoyl acyl transferases, the DHHC enzymes, so called because of their Asp-His-His-Cys (DHHC) catalytic ...
Suchi, Chaturvedi, Avinash, Sonawane
openaire   +2 more sources

S-palmitoylation in ferroptosis: molecular mechanisms, modulators, and interplay with autophagy

Apoptosis
S-palmitoylation, a reversible lipid post-translational modification, plays a dynamically regulatory role in cell death signaling pathways by modulating protein-membrane affinity, subcellular localization, and functional interactions. Emerging evidence has linked dysregulated S-palmitoylation to various pathologies including cancer and ...
Leilei, Wang, Chuan, Wang, Hong, He
openaire   +2 more sources

The shadow of cancer therapeutic resistance: Unveiling the role of S-palmitoylation

Drug Resistance Updates
Cancer therapeutic resistance remains a formidable challenge due to its diverse underlying mechanisms. S-palmitoylation (or called S-acylation), a reversible post-translational modification involving the attachment of long-chain fatty acids to cysteine residues, has emerged as a critical regulator of cancer progression and treatment response.
Xue, Yang, Mengke, Xu, Zhiqin, Deng, Bo, Xu   +3 more
openaire   +2 more sources

S-palmitoylation in bone biology: emerging insights and therapeutic potential

Biochemical Pharmacology
S-Palmitoylation, the reversible covalent attachment of palmitate to cysteine residues, is a dynamic post-translational lipid modification that regulates the localization, stability, and function of a wide array of proteins. Although traditionally linked to membrane trafficking and signaling, recent preliminary studies have begun to reveal its ...
Xing Ji, Chengyun Xu, Jiahao Luo, Xinhua Hu, Ximei Wu   +4 more
openaire   +2 more sources

Palmitoylation in apoptosis

Journal of Cellular Physiology, 2023
Qian Zheng
exaly  

Palmitoylation prevents sustained inflammation by limiting NLRP3 inflammasome activation through chaperone-mediated autophagy

Molecular Cell, 2023
exaly  

Protein palmitoylation and cancer

EMBO Reports, 2018
Scott J Dixon
exaly  

Full-Length P2X7 Structures Reveal How Palmitoylation Prevents Channel Desensitization

Cell, 2019
Craig Yoshioka, Steven E Mansoor
exaly  

Rapid and transient palmitoylation of the tyrosine kinase Lck mediates Fas signaling

Proceedings of the National Academy of Sciences of the United States of America, 2015
Askar M Akimzhanov, Darren Boehning, Boehning Darren   +2 more
exaly  

Assays of protein palmitoylation

Methods, 2006
Renaldo C Drisdel, William N Green
exaly