Preparation of Solid Self-Nanoemulsifying Drug Delivery Systems (S-SNEDDS) by Co-Extrusion of Liquid SNEDDS and Polymeric Carriers—A New and Promising Formulation Approach to Improve the Solubility of Poorly Water-Soluble Drugs [PDF]
Pharmaceuticals, 2022 The present study focused on a new formulation approach to improving the solubility of drugs with poor aqueous solubility. A hot melt extrusion (HME) process was applied to prepare drug-loaded solid self-nanoemulsifying drug delivery systems (S-SNEDDS ...
Fabian-Pascal Schmied +2 more
doaj +4 more sources
Adsorbent Precoating by Lyophilization: A Novel Green Solvent Technique to Enhance Cinnarizine Release from Solid Self-Nanoemulsifying Drug Delivery Systems (S-SNEDDS) [PDF]
Pharmaceutics, 2022 Background: Solidification by high surface area adsorbents has been associated with major obstacles in drug release. Accordingly, new approaches are highly demanded to solve these limitations.
Ahmad Yousef Tashish +3 more
doaj +3 more sources
A Solid Ultra Fine Self-Nanoemulsifying Drug Delivery System (S-SNEDDS) of Deferasirox for Improved Solubility: Optimization, Characterization, and In Vitro Cytotoxicity Studies [PDF]
Pharmaceuticals, 2020 The research work was designed to develop a solid self-nanoemulsifying drug delivery system (S-SNEDDS) of deferasirox (DFX). According to the solubility studies of DFX in different components, Peceol, Kolliphor EL, and Transcutol were selected as ...
Alaa Alghananim +5 more
doaj +3 more sources
Novel Solid Self-Nanoemulsifying Drug Delivery System (S-SNEDDS) for Oral Delivery of Olmesartan Medoxomil: Design, Formulation, Pharmacokinetic and Bioavailability Evaluation [PDF]
Pharmaceutics, 2016 The main purpose of this study was to develop a solid self-nanoemulsifying drug delivery system (S-SNEDDS) of Olmesartan (OLM) for enhancement of its solubility and dissolution rate.
Ali Nasr, Ahmed Gardouh, Mamdouh Ghorab
doaj +3 more sources
A novel solid self-nanoemulsifying drug delivery system (S-SNEDDS) for improved stability and oral bioavailability of an oily drug, 1-palmitoyl-2-linoleoyl-3-acetyl-rac-glycerol [PDF]
Drug Delivery, 2017 To develop a novel solid self-nanoemulsifying drug delivery system (S-SNEDDS) for a water-insoluble oily drug, 1-palmitoyl-2-linoleoyl-3-acetyl-rac-glycerol (PLAG) with improved stability and oral bioavailability, numerous S-SNEDDS were prepared with ...
Kyeong Soo Kim +11 more
doaj +3 more sources
Drug Delivery, 2021 Albendazolum (ABZ) is a BCS class II drug. It has challenging biopharmaceutical properties, which include poor solubility and dissolution rate. These properties have laid the ground for developing a supersaturated self-nanoemulsifying drug delivery ...
Alaa Alhazmi +2 more
exaly +2 more sources
Development and Evaluation of Paclitaxel‐Loaded Self‐Nanoemulsifying Drug Delivery System for Enhanced Cancer Therapy: A Promising Alternative to Cremophor EL–Based Formulation [PDF]
IET Nanobiotechnology, Volume 2026, Issue 1, 2026.Background and Purpose Paclitaxel’s clinical use is limited by poor aqueous solubility and Cremophor EL–related toxicity in commercial formulations. This study aimed to develop a self‐nanoemulsifying drug delivery system (SNEDDS) to improve paclitaxel solubility, bioavailability, and anticancer efficacy.
Alshaimaa M. Almehmady +7 more
wiley +2 more sources
Epigallocatechin‐3‐Gallate Encapsulated SNEDDS: A Novel Approach for Neuroprotection in Alzheimer’s Disease [PDF]
Alzheimer's &Dementia, Volume 21, Issue S5, December 2025.Abstract Background Alzheimer's disease (AD) is a progressive neurodegenerative condition associated with cognitive decline and impaired neurocognitive function. It is characterized by neural degeneration, loss of brain tissue, accumulation of amyloid‐beta (Aβ) plaques and neurofibrillary tangles. Even though, several phytochemicals, including fisetin,
Biswajit Pal +4 more
wiley +2 more sources
Formulation and Evaluation of Isorhamnetin SNEDDS for Neuroprotection in Alzheimer's Disease [PDF]
Alzheimer's &Dementia, Volume 21, Issue S5, December 2025.Abstract Background Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by memory loss, cognitive decline, and behavioral changes. The disease is marked by the accumulation of amyloid‐beta plaques and tau tangles, which disrupt neuronal function and lead to cell death.
Sambita Panda +5 more
wiley +2 more sources
Comparative Stability and Anesthetic Evaluation of Holy Basil Essential Oil Formulated in SNEDDS and Microemulsion Systems in Cyprinus carpio var. Koi [PDF]
PharmaceuticsBackground/Objectives: Holy basil (Ocimum tenuiflorum L.) essential oil exhibits antioxidant, antimicrobial, and anesthetic activities, mainly due to eugenol, methyl eugenol, and β-caryophyllene. However, its clinical application is limited by poor water
Kantaporn Kheawfu +4 more
doaj +2 more sources