Results 21 to 30 of about 21,088,255 (155)

Solid Self-Nano Emulsifying Nanoplatform Loaded with Tamoxifen and Resveratrol for Treatment of Breast Cancer

Pharmaceutics, 2022
The solid self-nanoemulsifying drug delivery system (s-SNEDDS) is a growing platform for the delivery of drugs via oral route. In the present work, tamoxifen (TAM) was loaded in SNEDDS with resveratrol (RES), which is a potent chemotherapeutic ...
Nupur Shrivastava, Ankit Parikh, Rikeshwer Prasad Dewangan, Largee Biswas, Anita Kamra Verma, Saurabh Mittal, Javed Ali, Sanjay Garg, Sanjula Baboota   +8 more
doaj   +1 more source

Self-nanoemulsifying drug delivery systems (SNEDDS) for solubility enhancement - new approaches for determining appropriate formulations for liquid SNEDDS and their conversion to solid SNEDDS [PDF]

, 2022
The poor aqueous solubility of many drug substances has been addressed using different solubility enhancement approaches in the pharmaceutical technology field over the last decades.
Schmied, Fabian-Pascal (Dr.)
core   +1 more source

Development of Guar Gum-Pectin-Based Colon Targeted Solid Self-Nanoemulsifying Drug Delivery System of Xanthohumol

Pharmaceutics, 2022
Present study deciphers development of oral polysaccharide-based colon targeted solid self-nanoemulsifying drug delivery system (S-SNEDDS) of xanthohumol (XH).
Mahesh Hanmantrao, Sourabh Chaterjee, Rajan Kumar, Sukriti Vishwas, Vancha Harish, Omji Porwal, Mohammed Alrouji, Othman Alomeir, Sharif Alhajlah, Monica Gulati, Gaurav Gupta, Kamal Dua, Sachin Kumar Singh   +12 more
doaj   +1 more source

Development of Piperine-Loaded Solid Self-Nanoemulsifying Drug Delivery System: Optimization, In-Vitro, Ex-Vivo, and In-Vivo Evaluation

Nanomaterials, 2021
Hypertension is a cardiovascular disease that needs long-term medication. Oral delivery is the most common route for the administration of drugs. The present research is to develop piperine self-nanoemulsifying drug delivery system (PE-SNEDDS) using ...
Ameeduzzafar Zafar, Syed Sarim Imam, Nabil K. Alruwaili, Omar Awad Alsaidan, Mohammed H. Elkomy, Mohammed M. Ghoneim, Sultan Alshehri, Ahmed Mahmoud Abdelhaleem Ali, Khalid Saad Alharbi, Mohd Yasir, Kaveripakkam M. Noorulla, Sami I. Alzarea, Abdullah S. Alanazi   +12 more
doaj   +1 more source

Enhancement of Icariin Aphrodisiac Effect by Solid-SNEDDS Method Using Shark Liver Oil Phase [PDF]

, 2023
The Epimedium brevicornu Maxim plant contains icariin, a flavonoid compound known for its aphrodisiac effects. However, icariin has low solubility and bioavailability. This study aims to find the best formula for S-SNEDDS icariin, its physical properties,
Wahyuningsih, Iis, Nurani, Laela H., Indratmoko, Septiana   +2 more
core   +1 more source

Combined Self-Nanoemulsifying and Solid Dispersion Systems Showed Enhanced Cinnarizine Release in Hypochlorhydria/Achlorhydria Dissolution Model

Pharmaceutics, 2021
The study aims to design a novel combination of drug-free solid self-nanoemulsifying drug delivery systems (S-SNEDDS) + solid dispersion (SD) to enhance cinnarizine (CN) dissolution at high pH environment caused by hypochlorhydria/achlorhydria.
Ahmad A. Shahba, Ahmad Y. Tashish, Fars K. Alanazi, Mohsin Kazi   +3 more
doaj   +1 more source

Development and pharmacokinetic evaluation of Neusilin® US2-based S-SNEDDS tablets for bosentan: Fasted and fed states bioavailability, IVIS® real-time biodistribution, and ex-vivo imaging

, 2023
The study reported here aimed to develop and optimize the S-SNEDDS tablet of bosentan (BOS) and to investigate its pharmacokinetic and biodistribution properties. The BOS-loaded SNEDDS have been developed and characterized in a previous study.
Zeynep Safak TEKSIN, Duygu YILMAZ USTA, Olgac, SEVAL, Teksin, Zeynep Şafak, Yılmaz Usta, Duygu, Tımur, Burcu, Burcu TIMUR, Seval OLGAC   +7 more
core   +1 more source

Understanding the effect of lipid formulation loading and ethanol as a diluent on solidification of pitavastatin super-saturable SNEDDS using factorial design approach

Research in Pharmaceutical Sciences, 2019
Solidification of a preconcentrate lipid formulation namely self-nano emulsifying drug delivery system (SNEDDS) is required to achieve feasibility, flexibility, and a new concept of “dry nano-emulsion”.
Ilham Kuncahyo, Syaiful Choiri, Achmad Fudholi, Abdul Rohman, Ronny Martien   +4 more
doaj   +1 more source

Self-nanoemulsifying drug delivery systems (SNEDDS) for oral delivery of Garcinia kola seeds ethanolic extract: formulation and in vivo antimalarial activity. [PDF]

Journal of Pharmacy & Pharmacognosy Research, 2020
Context: Garcinia kola seeds are widely used in Congolese traditional medicine to treat uncomplicated malaria. While the ethanolic extract of these seeds (GK) is reputed for oral antimalarial activity, some of its constituents have shown poor water ...
Grady K. Mukubwa, Christian I. Nkanga, Aristote B. Buya, Jérémie K. Mbinze, Rui W.M. Krause, Patrick B. Memvanga   +5 more
doaj  

Development and optimization of Ropinirole loaded self-nanoemulsifying tablets

Future Journal of Pharmaceutical Sciences, 2023
Background The present research work aims to develop a Ropinirole-loaded self-Nanoemulsifying Drug Delivery system. Ropinirole has limited oral bioavailability due to substantial first-pass metabolism, which ultimately results in poor oral ...
Krunal Detholia, Amrutha Mohandas, Umang Varia, Mukesh Jadeja, Hitesh Katariya   +4 more
doaj   +1 more source